Arthritis Research & Therapy

Epigenetics and lupus

B Richardson

Follicular helper T Cells and the B cells they help

A Poholek, J-Y Choi, S Hernandez, J Weinstein, S Kim, V Bunin, J Odegard, L DiPlacido, J Craft

Longitudinal analysis of mRNA transcripts and plasma proteins to define a biomarker associated with lupus disease activity

M Olferiev, W-T Huang, KA Kirou, E Gkrouzman, D Lundsgaard, KS Frederiksen, J Fleckner, MK Crow

New therapies

David Wofsy

MicroRNA-3148 modulates differential gene expression of the SLE-associated TLR7 variant

Y Deng, J Zhao, D Sakurai, KM Kaufman, JC Edberg, RP Kimberly, DL Kamen, GS Gilkeson, CO Jacob, RH Scofield, CD Langefeld, JA Kelly, ME Alarcón-Riquelme, JB Harley, TJ Vyse, BI Freedman, PM Gaffney, KM Sivils, JA James, TB Niewold, RM Cantor, W Chen, BH Hahn, EE Brown, BP Tsao

Differential DNA methylation associated with anti-dsDNA autoantibody production in systemic lupus erythematosus

SA Chung, J French, KE Taylor, E Elboudwarej, HL Quach, LF Barcellos, LA Criswell

Area-level socioeconomic status and variation in medication use among Medicaid enrollees with incident systemic lupus erythematosus, 2000 to 2004

CH Feldman, LT Hiraki, J Lui, GS Alarcón, MA Fischer, J Yazdany, KH Costenbader

SLE risk alleles and cell development and activation

SJ Kim, N Manjarrez Orduno, PK Gregersen, B Diamond

Genetic-epigenetic interaction in lupus

AH Sawalha

Serum chemokine levels predict flares of disease activity in two independent systemic lupus erythematosus cohorts

H Bilgic, T Koeuth, J Wilson, M Petri, E Baechler Gillespie

Major congenital anomalies in children born to women with systemic lupus erythematosus

E Vinet, CA Pineau, AE Clarke, M Kaouache, C Gordon, R Platt, S Bernatsky

Contemporary estimates of the risk of end-stage renal disease in the first decade of proliferative lupus nephritis

MM Ward, M Tektonidou

Impact of systemic lupus erythematosus organ damage on unemployment or disability from a population-based cohort

SS Lim, M Agan, CM Drenkard

Population-based study of preventable infections in hospitalized patients with systemic lupus erythematosus

CE Barber, C Barnabe, D Marshall, J Esdaile

Lung cancer in systemic lupus erythematosus

M Kale, R Ramsey-Goldman, S Bernatsky, MB Urowitz, D Gladman, PR Fortin, M Petri, E Yelin, S Manzi, S Edworthy, O Nived, S-C Bae, D Isenberg, A Rahman, JG Hanly, C Gordon, S Jacobsen, E Ginzler, DJ Wallace, GS Alarcón, MA Dooley, L Gottesman, K Steinsson, A Zoma, J-L Senécal, S Barr, G Sturfelt, L Dreyer, L Criswell, J Sibley, JL Lee, AE Clarke

Lymphoma risk in systemic lupus: effects of treatment versus disease activity

AE Clarke, S Bernatsky, KH Costenbader, MB Urowitz, DD Gladman, PR Fortin, M Petri, S Manzi, DA Isenberg, A Rahman, D Wallace, C Gordon, C Peschken, MA Dooley, EM Ginzler, C Aranow, SM Edworthy, O Nived, S Jacobsen, G Ruiz-Irastorza, E Yelin, SG Barr, L Criswell, G Sturfelt, L Dreyer, I Blanco, L Gottesman, CH Feldman, R Ramsey-Goldman

Usual source of care and geographic region are largest predictors of healthcare quality for incident lupus nephritis in US Medicaid recipients

J Yazdany, C Feldman, J Liu, MM Ward, MA Fischer, KH Costenbader

Neuropsychiatric events in SLE: determination of attribution and assessment of outcome

JG Hanly

Seafood consumption and persistent organic pollutants as triggers of autoimmunity among Gullah African Americans

DL Kamen, MM Peden-Adams, JE Vena, GS Gilkeson, TC Hulsey, L Moultrie, BE Stevens

Rising prevalence of systemic autoimmune rheumatic disease: increased awareness, increased disease or increased survival?

CA Peschken, CA Hitchon

Soluble E-selectin may predict progression of subclinical atherosclerosis, as measured by coronary artery calcium score and aorta calcium score, in women with systemic lupus erythematosus

A Lertratanakul, P Wu, A Dyer, W Pearce, G Kondos, D Edmundowicz, J Carr, R Ramsey-Goldman

Serum α-chlorofatty acid as a biomarker for baseline subclinical cardiovascular disease in systemic lupus erythematosus

MA Mahieu, C Guild, CJ Albert, G Kondos, J Carr, D Edmundowicz, DA Ford, R Ramsey-Goldman

Differing environmental risk factors for membranous versus proliferative lupus nephritis

MA Dooley, CG Parks, GS Cooper

B cells at the adaptive-innate immune system interface in SLE

JH Anolik, A Palanichamy, J Bauer, J Barnard, J Biear, R Dedrick, I Sanz, J Liesveld, E Baechler

In situ cognate interactions between T-follicular helper cells and B cells characterize severe tubulointerstitial inflammation in human lupus nephritis

MR Clark, M Giger, Y Jiang, V Liarski

SLE patients and autoantibody-positive healthy individuals display unique cytokine profiles: shared features of inflammation as well as select features of immunosuppression in autoantibody-positive healthy individuals

LL Ritterhouse, HT Maecker, CG Fathman, JT Merrill, JM Guthridge, JA James

Regulatory natural autoantibodies suppress inflammation and SLE disease activity

GJ Silverman, J Vas, C Grönwall

Genetic polymorphisms leading to altered T-cell and dendritic cell function cooperate to produce expansion of proinflammatory T-cell subsets in NZB c1 congenic mice

N Talaei, C Landolt-Marticorena, B Noamani, E Pau, N-H Chang, JE Wither

Abstract withdrawn

Dysregulation of the serine/threonine phosphatase PP2A contributes to autoimmunity

JC Crispín

Spontaneous aggregation of the anti-viral MAVS protein in systemic lupus erythematosus: a possible cause of excessive type I interferon production

PL Cohen, B Hilliard, W-H Shao

IRF5 expression profiling in SLE patients: new leads to a pathogenic signature?

BJ Barnes, RC Stone, P Du, D Feng

Role of MIF gene polymorphisms in systemic lupus erythematosus and prospects for therapeutic intervention

R Bucala

Interplay of neutrophils and type I interferons in the development of end-organ damage in SLE

MJ Kaplan

Metabolic control of systemic lupus erythematosus: convergence of genetic and environmental factors on mitochondrial dysfunction and mTOR reveal treatment targets in lupus

A Perl

Microparticles as autoantigens in human and murine lupus

A Ullal, DS Pisetsky

Innate sensors for nucleic acids and lupus pathogenesis

AN Theofilopoulos, R Gonzalez-Quintial, Y-T Koh, R Baccala, DH Kono

Evaluating the B-cell C3d:CR2 innate-adaptive immune interaction as a therapeutic target in lupus

VM Holers, JM Thurman, JP Hannan, L Kulik

PROMISSE: progress in understanding pregnancy complications in patients with SLE

JE Salmon

Complement deficiencies and susceptibility to systemic lupus erythematosus revisited

KB Elkon, DM Santer, A Wiedeman

Connecting the molecular dots from inaccessible antigen to organ injury in the pathogenesis of cardiac manifestations of neonatal lupus

JP Buyon

MicroRNAs in innate immune responses and autoimmune diseases

EKL Chan

Skin-antigen specific antibodies are detected in UV irradiation and TLR7 agonist induced lupus-like disease in autoimmune prone NOD mice and in pediatric SLE

M Ghoreishi, L Tucker, JP Dutz

SLE: insights from array-based proteomics

T Wu, Y Du, L Davis, C Mohan

Renal flare as a biomarker of incident and progressive chronic kidney disease in patients with lupus nephritis

S Parikh, A McKinley, BH Rovin

Cytokine profiles of lupus patients with or without nephritis

BH Rovin, H Song, CL Hines, X Zhang

Which lupus trial endpoints best reflect clinical judgment or biomarker improvement?

A Thanou, M Munroe, S Kamp, F Carthen, JA James, JT Merrill

'MiLES' population-based survey of the incidence and prevalence of systemic lupus erythematosus in Southeastern Michigan

EC Somers, W Marder, P Cagnoli, EE Lewis, P DeGuire, C Gordon, CG Helmick, L Wang, JJ Wing, JP Dhar, J Liesen, WJ McCune

Sociodemographic characteristics of SLE patients in a large metropolitan area with a high Afro-Caribbean population

J Cabas-Vargas, NM Patel, J Cohen, EM Ginzler

High score on PREDICTS is associated with 10-fold increased odds for the progression of subclinical atherosclerosis in SLE

M McMahon, Lori Sahakian, J Grossman, B Skaggs, J Fitzgerald, C Charles-Schoeman, N Ragavendra, A Gorn, G Karpouzas, M Weisman, D Wallace, B Hahn

Thinking toward improved treatments of systemic lupus erythematosus

BH Hahn, J Grossman, B Skaggs, E Lourenco, M Wong

Hopkins Lupus Cohort: assessment of treatment effects

M Petri

Risk of pulmonary embolism and deep vein thrombosis in systemic lupus erythematosus: a population-based cohort study

JA Aviña-Zubieta, D Lacaille, EC Sayre, J Kopec, HK Choi, JM Esdaile

Poor methodological reporting in lupus clinical trials found in Cochrane reviews

CH Goldsmith

Development validation and reliability of the Systemic Lupus Erythematosus Disease Activity Index 2000 Responder Index-50

Z Touma, DD Gladman, MB Urowitz

Clinical and immunological response to pneumococcal vaccination in pediatric systemic lupus erythematosus

D Rigdon, AC Gotte, MG Punaro, TB Wright

Role of anti-Ro autoantibodies in systemic lupus erythematosus patients with recurrent myositis

S Umer, S Hayat, G Caldito, SM Berney

Variation in renal biopsy and medication prescribing practices among pediatric Medicaid patients with lupus nephritis prior to end-stage renal disease in the US, 2000 to 2004

LT Hiraki, CH Feldman, J Liu, GS Alarcón, MA Fischer, WC Winkelmayer, KH Costenbader

Hospitalizations in patients with systemic lupus erythematosus: updated analyses from 2006 to 2011

K Chan, A Dekis, AE Clarke, CA Pineau, E Vinet, E Nashi, S Bernatsky

B-cell receptor signaling studies in patients with lupus: preliminary results

M Faludi, A Mao, E Vinet, A Clarke, C Pineau, S Bernatsky, E Nashi

Lupus cardiomyopathy: a reversible form of left ventricular dysfunction

ML Ishimori, M Agarwal, RK Ng, LD Nugent, DJ Wallace, RJ Siegel, MH Weisman

Prevalence of angina in patients with systemic lupus erythematosus

ML Ishimori, NJ Gal, A Rogatko, DS Berman, A Wilson, DJ Wallace, NB Merz, MH Weisman

Functional genetic polymorphisms in ILT3 are associated with decreased surface expression on dendritic cells and increased serum cytokines in lupus patients

MA Jensen, KC Patterson, AA Kumar, M Kumabe, BS Franek, TB Niewold

Nonlymphoma hematological malignancies in systemic lupus erythematosus

M Lu, R Ramsey-Goldman, S Bernatsky, M Petri, S Manzi, MB Urowitz, D Gladman, PR Fortin, E Ginzler, E Yelin, S-C Bae, DJ Wallace, S Jacobsen, MA Dooley, CA Peschken, GS Alarcón, O Nived, L Gottesman, L Criswell, G Sturfelt, L Dreyer, JL Lee, AE Clarke