Skip to main content
Erschienen in: Critical Care 1/2008

01.02.2008 | Commentary

Effect of sepsis therapies on health-related quality of life

verfasst von: Sara E Erickson, Greg S Martin

Erschienen in: Critical Care | Ausgabe 1/2008

Einloggen, um Zugang zu erhalten

Abstract

Sepsis is one of the most common conditions encountered in the intensive care unit and is the 10th leading cause of death overall in the United States. Both long-term survival and health-related quality of life are reduced in survivors of sepsis, yet there is little knowledge of the effect of sepsis-specific interventions on either long-term survival or health-related quality of life. The present article discusses the importance of studying health-related quality of life as it relates to sepsis management strategies, particularly in the context of pharmacologic therapy with recombinant human activated protein C.
Literatur
1.
Zurück zum Zitat Longo CJ, Heyland DK, Fisher HN, Fowler RA, Martin CM, Day AG: A long-term follow-up study investigating health-related quality of life and resource use in survivors of severe sepsis: comparison of recombinant human activated protein C with standard care. Crit Care 2007, 11: R128. 10.1186/cc6195PubMedCentralCrossRefPubMed Longo CJ, Heyland DK, Fisher HN, Fowler RA, Martin CM, Day AG: A long-term follow-up study investigating health-related quality of life and resource use in survivors of severe sepsis: comparison of recombinant human activated protein C with standard care. Crit Care 2007, 11: R128. 10.1186/cc6195PubMedCentralCrossRefPubMed
2.
Zurück zum Zitat Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR: Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001, 29: 1303-1310. 10.1097/00003246-200107000-00002CrossRefPubMed Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR: Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001, 29: 1303-1310. 10.1097/00003246-200107000-00002CrossRefPubMed
3.
Zurück zum Zitat Martin GS, Mannino DM, Eaton S, Moss M: The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003, 348: 1546-1554. 10.1056/NEJMoa022139CrossRefPubMed Martin GS, Mannino DM, Eaton S, Moss M: The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003, 348: 1546-1554. 10.1056/NEJMoa022139CrossRefPubMed
4.
Zurück zum Zitat Padkin A, Goldfrad C, Brady AR, Young D, Black N, Rowan K: Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland. Crit Care Med 2003, 31: 2332-2338. 10.1097/01.CCM.0000085141.75513.2BCrossRefPubMed Padkin A, Goldfrad C, Brady AR, Young D, Black N, Rowan K: Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland. Crit Care Med 2003, 31: 2332-2338. 10.1097/01.CCM.0000085141.75513.2BCrossRefPubMed
5.
Zurück zum Zitat Quartin AA, Schein RM, Kett DH, Peduzzi PN: Magnitude and duration of the effect of sepsis on survival. Department of Veterans Affairs Systemic Sepsis Cooperative Studies Group. JAMA 1997, 277: 1058-1063. 10.1001/jama.277.13.1058CrossRefPubMed Quartin AA, Schein RM, Kett DH, Peduzzi PN: Magnitude and duration of the effect of sepsis on survival. Department of Veterans Affairs Systemic Sepsis Cooperative Studies Group. JAMA 1997, 277: 1058-1063. 10.1001/jama.277.13.1058CrossRefPubMed
6.
Zurück zum Zitat Perl TM, Dvorak L, Hwang T, Wenzel RP: Long-term survival and function after suspected gram-negative sepsis. JAMA 1995, 274: 338-345. 10.1001/jama.274.4.338CrossRefPubMed Perl TM, Dvorak L, Hwang T, Wenzel RP: Long-term survival and function after suspected gram-negative sepsis. JAMA 1995, 274: 338-345. 10.1001/jama.274.4.338CrossRefPubMed
7.
Zurück zum Zitat Heyland DK, Hopman W, Coo H, Tranmer J, McColl MA: Long-term health-related quality of life in survivors of sepsis. Short Form 36: a valid and reliable measure of health-related quality of life. Crit Care Med 2000, 28: 3599-3605. 10.1097/00003246-200011000-00006CrossRefPubMed Heyland DK, Hopman W, Coo H, Tranmer J, McColl MA: Long-term health-related quality of life in survivors of sepsis. Short Form 36: a valid and reliable measure of health-related quality of life. Crit Care Med 2000, 28: 3599-3605. 10.1097/00003246-200011000-00006CrossRefPubMed
8.
Zurück zum Zitat Angus DC, Laterre PF, Helterbrand J, Ely EW, Ball DE, Garg R, Weissfeld LA, Bernard GR: The effect of drotrecogin alfa (activated) on long-term survival after severe sepsis. Crit Care Med 2004, 32: 2199-2206. 10.1097/01.CCM.0000114816.62331.08CrossRefPubMed Angus DC, Laterre PF, Helterbrand J, Ely EW, Ball DE, Garg R, Weissfeld LA, Bernard GR: The effect of drotrecogin alfa (activated) on long-term survival after severe sepsis. Crit Care Med 2004, 32: 2199-2206. 10.1097/01.CCM.0000114816.62331.08CrossRefPubMed
9.
Zurück zum Zitat Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, et al.: Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001, 344: 699-709. 10.1056/NEJM200103083441001CrossRefPubMed Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, et al.: Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001, 344: 699-709. 10.1056/NEJM200103083441001CrossRefPubMed
10.
Zurück zum Zitat Ely EW, Laterre PF, Angus DC, Helterbrand JD, Levy H, Dhainaut JF, Vincent JL, Macias WL, Bernard GR: Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med 2003, 31: 12-19. 10.1097/00003246-200301000-00002CrossRefPubMed Ely EW, Laterre PF, Angus DC, Helterbrand JD, Levy H, Dhainaut JF, Vincent JL, Macias WL, Bernard GR: Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med 2003, 31: 12-19. 10.1097/00003246-200301000-00002CrossRefPubMed
11.
Zurück zum Zitat Abraham E, Laterre PF, Garg R, Levy H, Talwar D, Trzaskoma BL, Francois B, Guy JS, Bruckmann M, Rea-Neto A, et al.: Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. N Engl J Med 2005, 353: 1332-1341. 10.1056/NEJMoa050935CrossRefPubMed Abraham E, Laterre PF, Garg R, Levy H, Talwar D, Trzaskoma BL, Francois B, Guy JS, Bruckmann M, Rea-Neto A, et al.: Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. N Engl J Med 2005, 353: 1332-1341. 10.1056/NEJMoa050935CrossRefPubMed
12.
Zurück zum Zitat Friedrich JO, Adhikari NK, Meade MO: Drotrecogin alfa (activated): does current evidence support treatment for any patients with severe sepsis? Crit Care 2006, 10: 145. 10.1186/cc4947PubMedCentralCrossRefPubMed Friedrich JO, Adhikari NK, Meade MO: Drotrecogin alfa (activated): does current evidence support treatment for any patients with severe sepsis? Crit Care 2006, 10: 145. 10.1186/cc4947PubMedCentralCrossRefPubMed
13.
Zurück zum Zitat Mrus JM, Braun L, Yi MS, Linde-Zwirble WT, Johnston JA: Impact of HIV/AIDS on care and outcomes of severe sepsis. Crit Care 2005, 9: R623-R630. 10.1186/cc3811PubMedCentralCrossRefPubMed Mrus JM, Braun L, Yi MS, Linde-Zwirble WT, Johnston JA: Impact of HIV/AIDS on care and outcomes of severe sepsis. Crit Care 2005, 9: R623-R630. 10.1186/cc3811PubMedCentralCrossRefPubMed
14.
Zurück zum Zitat Danai PA, Moss M, Mannino DM, Martin GS: The epidemiology of sepsis in patients with malignancy. Chest 2006, 129: 1432-1440. 10.1378/chest.129.6.1432CrossRefPubMed Danai PA, Moss M, Mannino DM, Martin GS: The epidemiology of sepsis in patients with malignancy. Chest 2006, 129: 1432-1440. 10.1378/chest.129.6.1432CrossRefPubMed
15.
Zurück zum Zitat Esper AM, Moss M, Lewis CA, Nisbet R, Mannino DM, Martin GS: The role of infection and comorbidity: factors that influence disparities in sepsis. Crit Care Med 2006, 34: 2576-2582. 10.1097/01.CCM.0000239114.50519.0EPubMedCentralCrossRefPubMed Esper AM, Moss M, Lewis CA, Nisbet R, Mannino DM, Martin GS: The role of infection and comorbidity: factors that influence disparities in sepsis. Crit Care Med 2006, 34: 2576-2582. 10.1097/01.CCM.0000239114.50519.0EPubMedCentralCrossRefPubMed
Metadaten
Titel
Effect of sepsis therapies on health-related quality of life
verfasst von
Sara E Erickson
Greg S Martin
Publikationsdatum
01.02.2008
Verlag
BioMed Central
Erschienen in
Critical Care / Ausgabe 1/2008
Elektronische ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc6215

Weitere Artikel der Ausgabe 1/2008

Critical Care 1/2008 Zur Ausgabe

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Hinter dieser Appendizitis steckte ein Erreger

23.04.2024 Appendizitis Nachrichten

Schmerzen im Unterbauch, aber sonst nicht viel, was auf eine Appendizitis hindeutete: Ein junger Mann hatte Glück, dass trotzdem eine Laparoskopie mit Appendektomie durchgeführt und der Wurmfortsatz histologisch untersucht wurde.

Ärztliche Empathie hilft gegen Rückenschmerzen

23.04.2024 Leitsymptom Rückenschmerzen Nachrichten

Personen mit chronischen Rückenschmerzen, die von einfühlsamen Ärzten und Ärztinnen betreut werden, berichten über weniger Beschwerden und eine bessere Lebensqualität.

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.