Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Molecular Imaging and Biology
Erschienen in: Molecular Imaging and Biology 4/2023

16.05.2023 | Research Article

Effects of Escitalopram on the Functional Neural Circuits in an Animal Model of Adolescent Depression

verfasst von: Se Jong Oh, Namhun Lee, Kyung Rok Nam, Kyung Jun Kang, Sang Jin Han, Jae Yong Choi

Erschienen in: Molecular Imaging and Biology | Ausgabe 4/2023

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Although escitalopram is known to be an effective drug for adult depression, its disease-modifying efficacy on adolescents remains controversial. The present study aimed to evaluate the therapeutic effect of escitalopram on behavioral aspects as well as functional neural circuits by means of positron emission tomography.

Procedures

To generate the animal models of depression, restraint stress was used during the peri-adolescent period (RS group). Thereafter, escitalopram was administered after the end of stress exposure (Tx group). We performed NeuroPET studies of glutamate, glutamate, GABA, and serotonin systems.

Results

The Tx group showed no body weight change compared to the RS group. In the behavioral tests, the Tx group also displayed the similar time spent in open arms and immobility time to those for RS. In the PET studies, brain uptake values for the Tx group revealed no significant differences in terms of glucose, GABAA, and 5-HT1A receptor densities, but lower mGluR5 PET uptake compared to the RS group. In the immunohistochemistry, the Tx group showed the significant loss of neuronal cells in the hippocampus compared to the RS group.

Conclusion

The administration of escitalopram had no therapeutic effect on the adolescent depression.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
2.
Green MR, McCormick CM (2016) Sex and stress steroids in adolescence: gonadal regulation of the hypothalamic–pituitary–adrenal axis in the rat. Gen Comp Endocrinol 234:110–116PubMedCrossRef
3.
Collins A, Koechlin E (2012) Reasoning, learning, and creativity: frontal lobe function and human decision-making. PLoS Biol 10:1–16
4.
Cressman VL, Balaban J, Steinfeld S et al (2010) Prefrontal cortical inputs to the basal amygdala undergo pruning during late adolescence in the rat. J Comp Neurol 518:2693–2709PubMedPubMedCentral
5.
Giedd JN, Blumenthal J, Jeffries NO, Castellanos FX, Liu H, Zijdenbos A, Paus T, Evans AC, R JL (1999) Brain development during childhood and adolescence: a longitudinal MRI study. Nat Neurosci 2:861–863PubMedCrossRef
6.
7.
Johnson FK, Delpech JC, Thompson GJ et al (2018) Amygdala hyper-connectivity in a mouse model of unpredictable early life stress. Transl Psychiatry 8:1–14
8.
Petanjek Z, Judaš M, Šimić G et al (2011) Extraordinary neoteny of synaptic spines in the human prefrontal cortex. Proc Natl Acad Sci U S A 108:13281–13286PubMedPubMedCentralCrossRef
9.
10.
Shea MT, Hirschfeld RMA (1996) Chronic mood disorder and depressive personality. Psychiatr Clin North Am 19:103–120PubMedCrossRef
11.
Caspi A, Sugden K, Moffitt TE et al (2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science (80- ) 301:386–389CrossRef
12.
Dohrenwend BP, Levav I, Shrout PE et al (1992) Socioeconomic status and psychiatric disorders: the causation-selection issue. Science (80- ) 255:946–952CrossRef
13.
14.
15.
Felger JC, Lotrich FE (2013) Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications. Neuroscience 246:199–229PubMedCrossRef
16.
17.
18.
Harmer CJ (2008) Serotonin and emotional processing: does it help explain antidepressant drug action? Neuropharmacology 55:1023–1028PubMedCrossRef
19.
de Lima APN, Sandini TM, Reis-Silva TM, Massoco CO (2017) Long-lasting monoaminergic and behavioral dysfunctions in a mice model of socio-environmental stress during adolescence. Behav Brain Res 317:132–140PubMedCrossRef
20.
Chockalingam R, Gott BM, Conway CR (2019) Tricyclic antidepressants and monoamine oxidase inhibitors: are they too old for a new look? Handb Exp Pharmacol 250:37–48PubMedCrossRef
21.
Remick RA (1988) Anticholinergic side effects of tricyclic antidepressants and their management. Prog Neuropsychopharmacol Biol Psychiatry 12:225–231PubMedCrossRef
22.
Hillhouse TM, Porter JH (2015) A brief history of the development of antidepressant drugs: from monoamines to glutamate. Exp Clin Psychopharmacol 23:1–21PubMedPubMedCentralCrossRef
23.
Popik P, Paul I, Skolnick P et al (2008) Adaptation of N-methyl-D-aspartate (NMDA) receptors following antidepressant treatment: implications for the pharmacotherapy of depression. Pharmacopsychiatry 29:23–26
24.
Ferguson JM (2001) SSRI antidepressant medications: adverse effects and tolerability. Prim Care Companion J Clin Psychiatry 3:22–27PubMedPubMedCentral
25.
Boulenger JP, Huusom AKT, Florea I et al (2006) A comparative study of the efficacy of long-term treatment with escitalopram and paroxetine in severely depressed patients. Curr Med Res Opin 22:1331–1341PubMedCrossRef
26.
Cipriani A, Zhou X, Del Giovane C et al (2016) Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis. Lancet 388:881–890PubMedCrossRef
27.
Garland EJ, Ons SK (2016) Update on the use of SSRIs and SNRIs with children and adolescents in clinical practice. J Can Acad Child Adolesc Psychiatry 25:4–10
28.
Findling RL, Robb A, Bose A (2013) Escitalopram in the treatment of adolescent depression: a randomized, double-blind, placebo-controlled extension trial. J Child Adolesc Psychopharmacol 23:468–480PubMedPubMedCentralCrossRef
29.
Oh SJ, Lee N, Nam KR et al (2023) Effect of developmental stress on the in vivo neuronal circuits related to excitation–inhibition and mood in adulthood. Front Psychiatry 14:1–11CrossRef
30.
Seewoo BJ, Hennessy LA, Feindel KW et al (2023) Validation of chronic restraint stress model in young adult rats for the study of depression using longitudinal multimodal MR imaging. eNeuro 7:1–22
31.
Chiba S, Numakawa T, Ninomiya M et al (2012) Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex. Prog Neuro-Psychopharmacol Biol Psychiatry 39:112–119CrossRef
32.
Seok Moon B, Hyung Park J, Jin Lee H et al (2010) Highly efficient production of [18F]fallypride using small amounts of base concentration. Appl Radiat Isot 68:2279–2284CrossRef
33.
Lee N, Oh SJ, Park JW et al (2021) Evaluation of the effects of developmental trauma on neurotransmitter systems using functional molecular imaging. Int J Mol Sci 22:1–11
34.
Karayol R, Medrihan L, Warner-Schmidt JL et al (2021) Serotonin receptor 4 in the hippocampus modulates mood and anxiety. Mol Psychiatry 26:2334–2349PubMedPubMedCentralCrossRef
35.
Kennedy SH, Andersen HF, Lam RW (2006) Efficacy of escitalopram in the treatment of major depressive disorder compared with conventional selective serotonin reuptake inhibitors and venlafaxine XR: a meta-analysis. J Psychiatry Neurosci 31:122–131PubMedPubMedCentral
36.
Sussman N, Ginsberg DL, Bikoff J (2001) Effects of nefazodone on body weight: a pooled analysis of selective serotonin reuptake inhibitor- and imipramine-controlled trials. J Clin Psychiatry 62:256–260
37.
Fava M (2000) Weight gain and antidepressants. J Clin Psychiatry 61:37–41PubMed
38.
Blumenthal SR, Castro VM, Clements CC et al (2014) An electronic health records study of long-term weight gain following antidepressant use. JAMA Psychiat 71:889–896CrossRef
39.
Uher R, Mors O, Hauser J et al (2011) Changes in body weight during pharmacological treatment of depression. Int J Neuropsychopharmacol 14:367–375PubMedCrossRef
40.
Andreatini R, Bacellar LFS (1999) The relationship between anxiety and depression in animal models: a study using the forced swimming test and elevated plus-maze. Braz J Med Biol Res 32:1121–1126PubMedCrossRef
41.
Porsolt RD, Bertin A, Jalfre M (1977) Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther 229:327–336PubMed
42.
Choi JH, Kim MS (2022) Homeostatic regulation of glucose metabolism by the central nervous system. Endocrinol Metab 37:9–25CrossRef
43.
Kucukgoncu S, Kosir U, Zhou E, Sullivan E, Srihari VH, T C (2019) Glucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: a systematic review and meta-analysis. Early Interv Psychiatry 13:1021–1031PubMedCrossRef
44.
Gu X, Ke S, Wang Q et al (2021) Energy metabolism in major depressive disorder: recent advances from omics technologies and imaging. Biomed Pharmacother 141:111869PubMedCrossRef
45.
Hill KR, Gardus JD, Bartlett EA et al (2021) Measuring brain glucose metabolism in order to predict response to antidepressant or placebo: a randomized clinical trial. NeuroImage Clin 32:102858PubMedPubMedCentralCrossRef
46.
Rowe PM (1995) How do antidepressants work? Mol Med Today 1:395PubMed
47.
Luscher B, Fuchs T (2015) GABAergic control of depression-related brain states. Adv Pharmacol 73:97–144
48.
Yin YY, Wang YH, Liu WG et al (2021) The role of the excitation:inhibition functional balance in the mPFC in the onset of antidepressants. Neuropharmacology 191:108573PubMedCrossRef
49.
Soiza-Reilly M, Meye FJ, Olusakin J et al (2019) SSRIs target prefrontal to raphe circuits during development modulating synaptic connectivity and emotional behavior. Mol Psychiatry 24:726–745PubMedCrossRef
Metadaten
Titel
Effects of Escitalopram on the Functional Neural Circuits in an Animal Model of Adolescent Depression
verfasst von
Se Jong Oh
Namhun Lee
Kyung Rok Nam
Kyung Jun Kang
Sang Jin Han
Jae Yong Choi
Publikationsdatum
16.05.2023
Verlag
Springer International Publishing
Erschienen in
Molecular Imaging and Biology / Ausgabe 4/2023
Print ISSN: 1536-1632
Elektronische ISSN: 1860-2002
DOI
https://doi.org/10.1007/s11307-023-01825-6

Weitere Artikel der Ausgabe 4/2023

Molecular Imaging and Biology 4/2023 Zur Ausgabe

Research Article

Head-to-Head Comparison of Tc-99m-sestamibi SPECT/CT and C-11-L-Methionin PET/CT in Parathyroid Scanning Before Operation for Primary Hyperparathyroidism

Research Article

Predicting Soft Tissue Sarcoma Response to Neoadjuvant Chemotherapy Using an MRI-Based Delta-Radiomics Approach

Research Article

Identification of a Putative α-synuclein Radioligand Using an in silico Similarity Search

Research Article

Photoacoustic Microscopic Imaging of Cerebral Vessels for Intensive Monitoring of Metabolic Acidosis

Research Article

Halogen Replacement on the Lysine Side Chain of Lys-Urea-Glu-Based PSMA Inhibitors Leads to Significant Changes in Targeting Properties

Research Article

Impact of Arterial Input Function and Pharmacokinetic Models on DCE-MRI Biomarkers for Detection of Vascular Effect Induced by Stroma-Directed Drug in an Orthotopic Mouse Model of Pancreatic Cancer

Neu im Fachgebiet Radiologie

Screening-Mammografie offenbart erhöhtes Herz-Kreislauf-Risiko

26.04.2024 Mammografie Nachrichten

Routinemäßige Mammografien helfen, Brustkrebs frühzeitig zu erkennen. Anhand der Röntgenuntersuchung lassen sich aber auch kardiovaskuläre Risikopatientinnen identifizieren. Als zuverlässiger Anhaltspunkt gilt die Verkalkung der Brustarterien.

S3-Leitlinie zu Pankreaskrebs aktualisiert

23.04.2024 Pankreaskarzinom Nachrichten

Die Empfehlungen zur Therapie des Pankreaskarzinoms wurden um zwei Off-Label-Anwendungen erweitert. Und auch im Bereich der Früherkennung gibt es Aktualisierungen.

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

18.04.2024 Pädiatrische Notfallmedizin Nachrichten

Im Choosing-Wisely-Programm, das für die deutsche Initiative „Klug entscheiden“ Pate gestanden hat, sind erstmals Empfehlungen zum Umgang mit Notfällen von Kindern erschienen. Fünf Dinge gilt es demnach zu vermeiden.

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

13.04.2024 Klinik aktuell Kongressbericht

Die Teilnehmer eines Forums beim DGIM-Kongress waren sich einig: Fehler in der Medizin sind häufig in ungeeigneten Prozessen und mangelnder Kommunikation begründet. Gespräche mit Patienten und im Team können helfen.

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise