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Journal of Assisted Reproduction and Genetics

Erschienen in:

19.08.2017 | Assisted Reproduction Technologies

Elevated serum estradiol levels in artificial autologous frozen embryo transfer cycles negatively impact ongoing pregnancy and live birth rates

verfasst von: Rani Fritz, Sangita Jindal, Heather Feil, Erkan Buyuk

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 12/2017

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Abstract

Purpose

The aim of this study is to evaluate the correlation between serum estradiol (E₂) levels during artificial autologous frozen embryo transfer (FET) cycles and ongoing pregnancy/live birth rates (OP/LB).

Methods

A historical cohort study was conducted in an academic setting in order to correlate peak and average estradiol levels with ongoing pregnancy/live birth rates for all autologous artificial frozen embryo transfer cycles performed from 1/2011 to 12/2014.

Results

Average and peak E₂ levels from 110 autologous artificial FET cycles from 95 patients were analyzed. Average E₂ levels were significantly lower in cycles resulting in OP/LB compared to those that did not (234.1 ± 16.6 pg/ml vs. 315 ± 24.8 pg/ml, respectively, p = 0.04). Although peak E₂ levels were not significantly different between cycles resulting in OP/LB compared with those that did not (366.9 ± 27.7 pg/ml vs. 459.1 ± 32.3 pg/ml, respectively, p = 0.19), correlation analysis revealed a statistically significant (p = 0.02) downward trend in OP/LB rates with increasing peak E₂ levels.

Conclusions

This study suggests that elevated E₂ levels in artificial autologous FET cycles are associated with lower OP/LB rates. Estradiol levels should be monitored during artificial FET cycles.

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Titel: Elevated serum estradiol levels in artificial autologous frozen embryo transfer cycles negatively impact ongoing pregnancy and live birth rates
verfasst von: Rani Fritz
Sangita Jindal
Heather Feil
Erkan Buyuk
Publikationsdatum: 19.08.2017
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 12/2017
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-017-1016-1

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Springer Medizin

Elevated serum estradiol levels in artificial autologous frozen embryo transfer cycles negatively impact ongoing pregnancy and live birth rates

Abstract

Purpose

Methods

Results

Conclusions

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Conclusions

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