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Journal of Behavioral Medicine

Erschienen in:

05.02.2016

Endocrine dysregulation in women with irritable bowel syndrome according to Rome II criteria

verfasst von: Charlotte Markert, Kerstin Suarez-Hitz, Ulrike Ehlert, Urs M. Nater

Erschienen in: Journal of Behavioral Medicine | Ausgabe 3/2016

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Abstract

The etiology of the irritable bowel syndrome (IBS) is unexplained: biological, psychological and social factors must be considered. This study examined if differences in HPA-axis activity already exist in those who do not yet fulfill IBS criteria (i.e. “subthreshold IBS”). We also investigated whether there were differences between those who reported clinically relevant (i.e. distressing) IBS symptoms and those who did not. Thirty-six women were subdivided into three groups (IBS group, subthreshold IBS group, control group). Results showed differences in morning cortisol levels (U = 11.58; p < 0.05), with IBS patients showing a lower cortisol response compared to controls. Subthreshold IBS patients were comparable to controls regarding endocrine function. Diurnal cortisol levels did not differ between groups. Group comparisons between distressed subjects and non-distressed subjects regarding cortisol levels did not reach significance. The finding of endocrine abnormalities (at least in a sub-set of patients) is important since these might be associated with deficient pain processing in IBS.

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Titel: Endocrine dysregulation in women with irritable bowel syndrome according to Rome II criteria
verfasst von: Charlotte Markert
Kerstin Suarez-Hitz
Ulrike Ehlert
Urs M. Nater
Publikationsdatum: 05.02.2016
Verlag: Springer US
Erschienen in: Journal of Behavioral Medicine / Ausgabe 3/2016
Print ISSN: 0160-7715
Elektronische ISSN: 1573-3521
DOI: https://doi.org/10.1007/s10865-016-9718-x

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