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Journal of Cardiovascular Translational Research

Erschienen in:

01.08.2012

Enhanced Endothelialization of a New Stent Polymer Through Surface Enhancement and Incorporation of Growth Factor-Delivering Microparticles

verfasst von: Hao Xu, Kytai T. Nguyen, Emmanouil S. Brilakis, Jian Yang, Eric Fuh, Subhash Banerjee

Erschienen in: Journal of Cardiovascular Translational Research | Ausgabe 4/2012

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Abstract

In this study, we sought to develop strategies for improved endothelialization of a new polymer coating for vascular stents. Surface enhancement of the new poly-1,8-octanediol-co-citric acid (POC) polymer was achieved through conjugation of anti-CD34 antibody and incorporation of vascular endothelial growth factor and basic fibroblast growth factor-containing poly-lactic-co-glycolic acid microparticles to improve capture and proliferation of endothelial progenitor cells (EPC) and compared to untreated POC and poly-L-lactic acid (PLLA) polymer. Our results indicate that compared to PLLA, POC coating was more hemocompatible, with less platelet activation (p = 0.01), thrombogenicity (p < 0.05 for 20 and 30 min clot formation), and inflammatory response (IL-1β release, p = 0.0009; TNF-α release, p = 0.004). EPC adhesion and proliferation on POC were significantly improved with surface enhancement and microparticle incorporation compared to untreated POC (p = 0.006) and PLLA (p = 0.003). These results suggest a new strategy for enhancing endothelialization of polymeric coatings of vascular prostheses.

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Titel: Enhanced Endothelialization of a New Stent Polymer Through Surface Enhancement and Incorporation of Growth Factor-Delivering Microparticles
verfasst von: Hao Xu
Kytai T. Nguyen
Emmanouil S. Brilakis
Jian Yang
Eric Fuh
Subhash Banerjee
Publikationsdatum: 01.08.2012
Verlag: Springer US
Erschienen in: Journal of Cardiovascular Translational Research / Ausgabe 4/2012
Print ISSN: 1937-5387
Elektronische ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-012-9381-8

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