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Angiogenesis
Erschienen in: Angiogenesis 2/2017

04.04.2017 | Review Paper

Epigenetic approach for angiostatic therapy: promising combinations for cancer treatment

verfasst von: Robert H. Berndsen, U. Kulsoom Abdul, Andrea Weiss, Marloes Zoetemelk, Marije T. te Winkel, Paul J. Dyson, Arjan W. Griffioen, Patrycja Nowak-Sliwinska

Erschienen in: Angiogenesis | Ausgabe 2/2017

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Abstract

Cancer cells are often dependent on epigenetic pathways for their survival. Consequently, drugs that target the epigenome, rather than the underlying DNA sequence, are currently attracting considerable attention. In recent years, the first epigenetic drugs have been approved for cancer chemotherapy, mainly for hematological applications. Limitations in single-drug efficacies have thus far limited their application in the treatment of solid tumors. Nevertheless, promising activity for these compounds has been suggested when combined with other, distinctly targeted agents. In this review, we discuss the anti-angiogenic activity of histone deacetylase and DNA methyltransferase inhibitors and their combinations with other targeted (anti-angiogenic) therapeutics in treatment of solid tumors. The role that these inhibitors play in the inhibition of tumor angiogenesis, particularly in combination with other targeted agents, and the advantages they present over broad acting anticancer agents, are critically discussed.
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Metadaten
Titel
Epigenetic approach for angiostatic therapy: promising combinations for cancer treatment
verfasst von
Robert H. Berndsen
U. Kulsoom Abdul
Andrea Weiss
Marloes Zoetemelk
Marije T. te Winkel
Paul J. Dyson
Arjan W. Griffioen
Patrycja Nowak-Sliwinska
Publikationsdatum
04.04.2017
Verlag
Springer Netherlands
Erschienen in
Angiogenesis / Ausgabe 2/2017
Print ISSN: 0969-6970
Elektronische ISSN: 1573-7209
DOI
https://doi.org/10.1007/s10456-017-9551-z

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In der MONARCHE-3-Studie lebten Frauen mit fortgeschrittenem Hormonrezeptor-positivem, HER2-negativem Brustkrebs länger, wenn sie zusätzlich zu einem nicht steroidalen Aromatasehemmer mit Abemaciclib behandelt wurden; allerdings verfehlte der numerische Zugewinn die statistische Signifikanz.

ADT zur Radiatio nach Prostatektomie: Wenn, dann wohl länger

24.05.2024 Prostatakarzinom Nachrichten

Welchen Nutzen es trägt, wenn die Strahlentherapie nach radikaler Prostatektomie um eine Androgendeprivation ergänzt wird, hat die RADICALS-HD-Studie untersucht. Nun liegen die Ergebnisse vor. Sie sprechen für länger dauernden Hormonentzug.

Update Innere Medizin

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