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01.09.2004 | Letter to the Editor

Epithelioid and rhabdoid rhabdomyosarcoma in an adult patient: a diagnostic pitfall

verfasst von: Dimas Suárez-Vilela, Francisco Miguel Izquierdo-Garcia, Nieves Alonso-Orcajo

Erschienen in: Virchows Archiv | Ausgabe 3/2004

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Excerpt

Sir, adult rhabdomyosarcoma (RMS) constitutes a very small fraction of soft tissue sarcomas, estimated between 2% and 5% [1, 6]. These tumors present with different histological patterns [1, 6], the epithelioid RMSs [14] and the RMSs with rhabdoid cells being very uncommon [5, 7, 9, 12, 13]. We report a case of RMS in an adult patient, which was composed of cells with rhabdoid and epithelioid features. The histological appearance of this tumor was very unusual, and it raises differential diagnoses with neoplasms of other histogenetic origins. …
Literatur
1.
Zurück zum Zitat Ferrari A, Dileo P, Casanova M. Bertulli R, Meazza C, Gandola L, Navarria P, Colini P, Gronchi A, Olmi P, Fossati-Bellani F, Casali PG (2003) Rhabdomyosarcoma in adults. A retrospective analysis of 171 patients treated at a single institution. Cancer 98:571–580CrossRefPubMed Ferrari A, Dileo P, Casanova M. Bertulli R, Meazza C, Gandola L, Navarria P, Colini P, Gronchi A, Olmi P, Fossati-Bellani F, Casali PG (2003) Rhabdomyosarcoma in adults. A retrospective analysis of 171 patients treated at a single institution. Cancer 98:571–580CrossRefPubMed
2.
Zurück zum Zitat Folpe AL, McKenney JK, Brigde JA, Weiss SW (2002) Sclerosing rhabdomyosarcoma in adults. Report of four cases of a hyalinizing, matrix-rich variant of rhabdomyosarcoma that may be confused with osteosarcoma, chondrosarcoma or angiosarcoma. Am J Surg Pathol 26:1175–1183CrossRefPubMed Folpe AL, McKenney JK, Brigde JA, Weiss SW (2002) Sclerosing rhabdomyosarcoma in adults. Report of four cases of a hyalinizing, matrix-rich variant of rhabdomyosarcoma that may be confused with osteosarcoma, chondrosarcoma or angiosarcoma. Am J Surg Pathol 26:1175–1183CrossRefPubMed
3.
Zurück zum Zitat Frisch SM (1994) E1a induces the expression of epithelial characteristics. J Cell Biol 124:619–626CrossRefPubMed Frisch SM (1994) E1a induces the expression of epithelial characteristics. J Cell Biol 124:619–626CrossRefPubMed
4.
Zurück zum Zitat Fuller CE, Pfeifer J, Humphrey P, Bruch LA, Dehner LP, Perry A (2001) Chromosome 22q dosage in composite extrarenal rhabdoid tumors: clonal evolution or a phenotypic mimic? Hum Pathol 32:1102–1108CrossRefPubMed Fuller CE, Pfeifer J, Humphrey P, Bruch LA, Dehner LP, Perry A (2001) Chromosome 22q dosage in composite extrarenal rhabdoid tumors: clonal evolution or a phenotypic mimic? Hum Pathol 32:1102–1108CrossRefPubMed
5.
Zurück zum Zitat Gaffney EF, Dervan PA, Fletcher CDM (1993) Pleomorphic rhabdomyosarcoma in adulthood. Analysis of 11 cases with definition of diagnostic criteria. Am J Surg Pathol 17:601–609PubMed Gaffney EF, Dervan PA, Fletcher CDM (1993) Pleomorphic rhabdomyosarcoma in adulthood. Analysis of 11 cases with definition of diagnostic criteria. Am J Surg Pathol 17:601–609PubMed
6.
Zurück zum Zitat Hawkins WG, Hoos A, Antonescu CR, Urist MJ, Leung DHY, Gold JS, Woodruff JM, Lewis JJ, Brenna MF (2001) Clinicopathologic analysis of patients with adult rhabdomyosarcoma. Cancer 91:794–803CrossRefPubMed Hawkins WG, Hoos A, Antonescu CR, Urist MJ, Leung DHY, Gold JS, Woodruff JM, Lewis JJ, Brenna MF (2001) Clinicopathologic analysis of patients with adult rhabdomyosarcoma. Cancer 91:794–803CrossRefPubMed
7.
Zurück zum Zitat Hollowood K, Fletcher CDM (1994) Rhabdomyosarcoma in adults. Semin Diag Pathol 11:47–57 Hollowood K, Fletcher CDM (1994) Rhabdomyosarcoma in adults. Semin Diag Pathol 11:47–57
8.
Zurück zum Zitat Kempson RL, Fletcher CDM, Evans HL, Hendrickson MR, Sibley RK (2001) In: Rosai J, Sobin LH (eds) Tumors of the soft tissues. Atlas of tumor pathology, 3rd series. Armed Forces Institute of Pathology, Washington, DC Kempson RL, Fletcher CDM, Evans HL, Hendrickson MR, Sibley RK (2001) In: Rosai J, Sobin LH (eds) Tumors of the soft tissues. Atlas of tumor pathology, 3rd series. Armed Forces Institute of Pathology, Washington, DC
9.
Zurück zum Zitat Kodet R, Newton WA, Hamoudi AB, Asmar L (1991) Rhabdomyosarcomas with intermediate-filament inclusions and features of rhabdoid tumors. Light microscopic and immunohistochemical study. Am J Surg Pathol 15:257–267PubMed Kodet R, Newton WA, Hamoudi AB, Asmar L (1991) Rhabdomyosarcomas with intermediate-filament inclusions and features of rhabdoid tumors. Light microscopic and immunohistochemical study. Am J Surg Pathol 15:257–267PubMed
10.
Zurück zum Zitat Mentzel T, Katenkamp D (2000) Sclerosing, pseudovascular rhabdomyosarcoma in adults. Clinicopathological and immunohistochemical analysis of three cases. Virchows Arch 436:305–311CrossRefPubMed Mentzel T, Katenkamp D (2000) Sclerosing, pseudovascular rhabdomyosarcoma in adults. Clinicopathological and immunohistochemical analysis of three cases. Virchows Arch 436:305–311CrossRefPubMed
11.
Zurück zum Zitat Ogino S, Ro JY, Redline RW (2000) Malignant rhabdoid tumor: a phenotype? an entity?—a controversy revisited. Adv Anat Pathol 7:181–190PubMed Ogino S, Ro JY, Redline RW (2000) Malignant rhabdoid tumor: a phenotype? an entity?—a controversy revisited. Adv Anat Pathol 7:181–190PubMed
12.
Zurück zum Zitat Perez-Ordoñez B, Kandel RA, Bell R, Bédard YC (1998) Rhabdomyosarcoma with rhabdoid-like features. Pathol Res Pract 194:357–361PubMed Perez-Ordoñez B, Kandel RA, Bell R, Bédard YC (1998) Rhabdomyosarcoma with rhabdoid-like features. Pathol Res Pract 194:357–361PubMed
13.
Zurück zum Zitat Schürch W, Bégin LR, Seemayer TA, Lagacé R, Boivin J-C, Lamoreux C, Bluteau P, Piché J, Gabbiani G (1996) Pleomorphic soft tissue myogenic sarcomas of adulthood. A reappraisal in the mid-1990s. Am J Surg Pathol 20:131–147CrossRefPubMed Schürch W, Bégin LR, Seemayer TA, Lagacé R, Boivin J-C, Lamoreux C, Bluteau P, Piché J, Gabbiani G (1996) Pleomorphic soft tissue myogenic sarcomas of adulthood. A reappraisal in the mid-1990s. Am J Surg Pathol 20:131–147CrossRefPubMed
14.
Zurück zum Zitat Seidal T, Kindblom L-G, Angervall L (1989) Rhabdomyosarcoma in middle-aged and elderly individuals. APMIS 97:236–248PubMed Seidal T, Kindblom L-G, Angervall L (1989) Rhabdomyosarcoma in middle-aged and elderly individuals. APMIS 97:236–248PubMed
Metadaten
Titel
Epithelioid and rhabdoid rhabdomyosarcoma in an adult patient: a diagnostic pitfall
verfasst von
Dimas Suárez-Vilela
Francisco Miguel Izquierdo-Garcia
Nieves Alonso-Orcajo
Publikationsdatum
01.09.2004
Verlag
Springer-Verlag
Erschienen in
Virchows Archiv / Ausgabe 3/2004
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-004-1076-3

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