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01.12.2012 | Primary research | Ausgabe 1/2012 Open Access

Cancer Cell International 1/2012

Evaluation of antiproliferative and anti-inflammatory activities of methanol extract and its fractions from the Mediterranean sponge

Zeitschrift:
Cancer Cell International > Ausgabe 1/2012
Autoren:
Afef Dellai, Monia Deghrigue, Audrey Laroche-Clary, Hedi Ben Masour, Nabil Chouchane, Jacques Robert, Abderrahman Bouraoui
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2867-12-18) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

AD: made contribution to the study anti-inflammatory activities. MD: Was responsible for the conception and design, testing and data acquisition, analysis and data interpretation and drafted the manuscript. Audrey C-L: made contribution to anti-inflammatory activity. HBM made contribution to preparation of crude extract and its fractions of the defensive secretion from the Mediterranean sponge, Spongiaofficinalis and to their antiproliferative activities. AB made contribution to statistical analysis. All authors read and approved the final manuscript.

Abstract

Background

Without doubt, natural products have been, and still are, the cornerstone of the health care armamentarium. Of all natural sources, the marine environment is clearly the last great frontier for pharmaceutical and medical research.

Methods

This work progresses in the direction of identifying component(s) from the Mediterranean sponge, Spongia officinalis with pharmacological activities. In the present study we investigated the efficacy of methanol extract and its semi-purified fractions (F2, F3) from Spongia officinalis for their in vivo anti-inflammatory activity using the carrageenan-induced paw edema in rats and their in vitro antiproliferative effects by their potential cytotoxic activity using the MTT colorimetric method and clonogenic inhibition against three human cancer cell lines (A549, lung cell carcinoma, HCT15, colon cell carcinoma and MCF7, breast adenocarcinoma).

Results

The fractions F2 and F3 showed interesting anti-inflammatory and antiproliferative activities in a dose dependent manner.

Conclusions

The present study indicates that the methanolic extrac and its fractions from Spongia officinalis are a significant source of compounds with the antiproliferative and anti-inflammatory activities, and this may be useful for developing potential chemopreventive substances.
Zusatzmaterial
Authors’ original file for figure 1
12935_2012_346_MOESM1_ESM.pdf
Authors’ original file for figure 2
12935_2012_346_MOESM2_ESM.pdf
Authors’ original file for figure 3
12935_2012_346_MOESM3_ESM.pdf
Authors’ original file for figure 4
12935_2012_346_MOESM4_ESM.pdf
Literatur
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