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Japanese Journal of Radiology

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26.12.2017 | Original Article

Examining alterations in GABA concentrations in the basal ganglia of patients with Parkinson’s disease using MEGA-PRESS MRS

verfasst von: Elsadig E. A. Elmaki, Tao Gong, D. Menene Nkonika, Guangbin Wang

Erschienen in: Japanese Journal of Radiology | Ausgabe 3/2018

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Abstract

Purpose

The aim of this study was to compare the gamma-amino butyric acid (GABA) levels in the left basal ganglia (BG) of patients with Parkinson’s disease (PD) to those of healthy control (HC) volunteers using proton magnetic resonance spectroscopy (¹H MRS).

Materials and methods

The GABA+ signal—the composite signal from GABA, macromolecules (MMs), and homocarnosine—was detected. GABA+ levels were examined in 21 PD patients and 15 age- and sex-matched HCs. 3T-¹H-MRS using the Mescher–Garwood point-resolved spectroscopy (MEGA-PRESS) sequence was performed in order to detect GABA+ levels in the left BG, and the spectra were processed using the Gannet software. Differences in GABA+ levels between the two groups were analyzed using independent t-test analysis.

Results

The GABA+ levels were significantly lower (P < 0.001) in the left BG of the patients with PD (1.31 ± 0.21 i.u.) than in the left BG of the HCs (1.62 ± 0.26 i.u.).

Conclusion

The lower GABA+ levels in the left BG of the PD patients suggest that GABA plays an important role in the pathogenesis of PD. The reduced GABA+ levels in the PD patients may be associated with GABAergic dysfunction.

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Titel: Examining alterations in GABA concentrations in the basal ganglia of patients with Parkinson’s disease using MEGA-PRESS MRS
verfasst von: Elsadig E. A. Elmaki
Tao Gong
D. Menene Nkonika
Guangbin Wang
Publikationsdatum: 26.12.2017
Verlag: Springer Japan
Erschienen in: Japanese Journal of Radiology / Ausgabe 3/2018
Print ISSN: 1867-1071
Elektronische ISSN: 1867-108X
DOI: https://doi.org/10.1007/s11604-017-0714-z

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Examining alterations in GABA concentrations in the basal ganglia of patients with Parkinson’s disease using MEGA-PRESS MRS

Abstract

Purpose

Materials and methods

Results

Conclusion

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Abstract

Purpose

Materials and methods

Results

Conclusion

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