Skip to main content
Erschienen in: European Archives of Psychiatry and Clinical Neuroscience 7/2008

01.10.2008 | ORIGINAL ARTICLE

Executive performance of depressed suicide attempters: the role of suicidal ideation

verfasst von: Jens Westheide, Boris B. Quednow, Kai-Uwe Kuhn, Christian Hoppe, Déirdre Cooper-Mahkorn, Barbara Hawellek, Petra Eichler, Wolfgang Maier, Michael Wagner

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 7/2008

Einloggen, um Zugang zu erhalten

Abstract

Objective

Suicidal ideation has been related to cognitive rigidity whereas suicidal behaviour itself was associated with specific executive deficits. Yet it remains unclear if a distinct cognitive suicidal phenotype does exist. The aim of the present study was to further investigate the role of suicidal thinking for the neuropsychological performance in depressive suicide attempters.

Method

Depressive inpatients after a recent suicide attempt, who either had present suicidal ideation (n = 14) or not (n = 15) and healthy controls (n = 29) were recruited. The groups were assessed by means of executive tasks designed to capture impulsive decision-making, and with verbal memory and attention tests. Self-rating measures of impulsivity and aggression were further applied.

Results

Only patients with current suicidal ideation showed executive dysfunctions with impaired decision-making being the most salient. Verbal memory and attention were reasonably intact in all patients. All patients reported increased aggression.

Conclusion

Suicidal ideation is clearly associated with impaired cognitive performance. Our results suggest that executive deficits seen in depressive suicide attempters have a state-dependent component.
Literatur
1.
Zurück zum Zitat Antonucci AS, Gansler DA, Tan S, Bhadelia R, Patz S, Fulwiler C (2006) Orbitofrontal correlates of aggression and impulsivity in psychiatric patients. Psychiatry Res 147:213–220PubMedCrossRef Antonucci AS, Gansler DA, Tan S, Bhadelia R, Patz S, Fulwiler C (2006) Orbitofrontal correlates of aggression and impulsivity in psychiatric patients. Psychiatry Res 147:213–220PubMedCrossRef
2.
Zurück zum Zitat Apter A, van Praag HM, Plutchik R, Sevy S, Korn M, Brown SL (1990) Interrelationships among anxiety, aggression, impulsivity, and mood: a serotonergically linked cluster? Psychiatry Res 32:191–199PubMedCrossRef Apter A, van Praag HM, Plutchik R, Sevy S, Korn M, Brown SL (1990) Interrelationships among anxiety, aggression, impulsivity, and mood: a serotonergically linked cluster? Psychiatry Res 32:191–199PubMedCrossRef
3.
Zurück zum Zitat Arias B, Gasto C, Catalan R, Gutierrez B, Pintor L, Fananas L (2001) The 5-HT(2A) receptor gene 102T/C polymorphism is associated with suicidal behavior in depressed patients. Am J Med Genet 105:801–804PubMedCrossRef Arias B, Gasto C, Catalan R, Gutierrez B, Pintor L, Fananas L (2001) The 5-HT(2A) receptor gene 102T/C polymorphism is associated with suicidal behavior in depressed patients. Am J Med Genet 105:801–804PubMedCrossRef
4.
Zurück zum Zitat Austin MP, Mitchell P, Goodwin GM (2001) Cognitive deficits in depression: possible implications for functional neuropathology. Br J Psychiatry 178:200–206PubMedCrossRef Austin MP, Mitchell P, Goodwin GM (2001) Cognitive deficits in depression: possible implications for functional neuropathology. Br J Psychiatry 178:200–206PubMedCrossRef
5.
Zurück zum Zitat Baca-Garcia E, Diaz-Sastre C, Garcia Resa E, Blasco H, Braquehais Conesa D, Oquendo MA, Saiz-Ruiz J, de Leon J (2005) Suicide attempts and impulsivity. Eur Arch Psychiatry Clin Neurosci 255:152–156PubMedCrossRef Baca-Garcia E, Diaz-Sastre C, Garcia Resa E, Blasco H, Braquehais Conesa D, Oquendo MA, Saiz-Ruiz J, de Leon J (2005) Suicide attempts and impulsivity. Eur Arch Psychiatry Clin Neurosci 255:152–156PubMedCrossRef
6.
Zurück zum Zitat Ballmaier M, Toga AW, Blanton RE, Sowell ER, Lavretsky H, Peterson J, Pham D, Kumar A (2004) Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: an MRI-based parcellation of the prefrontal cortex. Am J Psychiatry 161:99–108PubMedCrossRef Ballmaier M, Toga AW, Blanton RE, Sowell ER, Lavretsky H, Peterson J, Pham D, Kumar A (2004) Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: an MRI-based parcellation of the prefrontal cortex. Am J Psychiatry 161:99–108PubMedCrossRef
7.
Zurück zum Zitat Bechara A, Damasio AR, Damasio H, Anderson SW (1994) Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50:7–15PubMedCrossRef Bechara A, Damasio AR, Damasio H, Anderson SW (1994) Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50:7–15PubMedCrossRef
8.
Zurück zum Zitat Bechara A, Damasio H, Tranel D, Anderson SW (1998) Dissociation of working memory from decision making within the human prefrontal cortex. J Neurosci 18:428–437PubMed Bechara A, Damasio H, Tranel D, Anderson SW (1998) Dissociation of working memory from decision making within the human prefrontal cortex. J Neurosci 18:428–437PubMed
9.
Zurück zum Zitat Beck AT, Beck R, Kovacs M (1975) Classification of suicidal behaviors: I. Quantifying intent and medical lethality. Am J Psychiatry 132:285–287PubMed Beck AT, Beck R, Kovacs M (1975) Classification of suicidal behaviors: I. Quantifying intent and medical lethality. Am J Psychiatry 132:285–287PubMed
10.
Zurück zum Zitat Beck AT, Kovacs M, Weissman A (1979) Assessment of suicidal intention: the scale for suicide ideation. J Consult Clin Psychol 47:343–352PubMedCrossRef Beck AT, Kovacs M, Weissman A (1979) Assessment of suicidal intention: the scale for suicide ideation. J Consult Clin Psychol 47:343–352PubMedCrossRef
11.
Zurück zum Zitat Best M, Williams JM, Coccaro EF (2002) Evidence for a dysfunctional prefrontal circuit in patients with an impulsive aggressive disorder. Proc Natl Acad Sci USA 99:8448–8453PubMedCrossRef Best M, Williams JM, Coccaro EF (2002) Evidence for a dysfunctional prefrontal circuit in patients with an impulsive aggressive disorder. Proc Natl Acad Sci USA 99:8448–8453PubMedCrossRef
12.
Zurück zum Zitat Biver F, Goldman S, Delvenne V, Luxen A, De Maertelaer V, Hubain P, Mendlewicz J, Lotstra F (1994) Frontal and parietal metabolic disturbances in unipolar depression. Biol Psychiatry 36:381–388PubMedCrossRef Biver F, Goldman S, Delvenne V, Luxen A, De Maertelaer V, Hubain P, Mendlewicz J, Lotstra F (1994) Frontal and parietal metabolic disturbances in unipolar depression. Biol Psychiatry 36:381–388PubMedCrossRef
13.
Zurück zum Zitat Bolla KI, Eldreth DA, Matochik JA, Cadet JL (2004) Sex-related differences in a gambling task and its neurological correlates. Cereb Cortex 14:1226–32 (Epub May 13, 2004)PubMedCrossRef Bolla KI, Eldreth DA, Matochik JA, Cadet JL (2004) Sex-related differences in a gambling task and its neurological correlates. Cereb Cortex 14:1226–32 (Epub May 13, 2004)PubMedCrossRef
14.
Zurück zum Zitat Brickenkamp R (1994) Tets d2: Aufmerksamkeits-Belastungs-Test. 8. Auflage. Hogrefe, Göttingen Brickenkamp R (1994) Tets d2: Aufmerksamkeits-Belastungs-Test. 8. Auflage. Hogrefe, Göttingen
15.
Zurück zum Zitat Burt DB, Zembar MJ, Niederehe G (1995) Depression and memory impairment: a meta-analysis of the association, its pattern, and specificity. Psychol Bull 117:285–305PubMedCrossRef Burt DB, Zembar MJ, Niederehe G (1995) Depression and memory impairment: a meta-analysis of the association, its pattern, and specificity. Psychol Bull 117:285–305PubMedCrossRef
16.
Zurück zum Zitat Buss AH, Durkee A (1957) An inventory for assessing different kinds of hostility. J Consult Psychol 21:343–349PubMedCrossRef Buss AH, Durkee A (1957) An inventory for assessing different kinds of hostility. J Consult Psychol 21:343–349PubMedCrossRef
17.
Zurück zum Zitat Casey BJ, Trainor RJ, Orendi JL, Schubert AB, Nystrom LE, Giedd JN, Castellanos FX, Haxby JV, Noll DC, Cohen JD, Forman SD, Dahl RE, Rapoport JL (1997) A developmental functional MRI study of prefrontal activation during performance of a Go-No-Go task. J Cognit Neurosci 9:835–847CrossRef Casey BJ, Trainor RJ, Orendi JL, Schubert AB, Nystrom LE, Giedd JN, Castellanos FX, Haxby JV, Noll DC, Cohen JD, Forman SD, Dahl RE, Rapoport JL (1997) A developmental functional MRI study of prefrontal activation during performance of a Go-No-Go task. J Cognit Neurosci 9:835–847CrossRef
18.
Zurück zum Zitat Cohen J (1988) Statistical power analysis for the behavioral sciences, 2nd edn. Lawrence Erlbaum Associates, Hillsdale Cohen J (1988) Statistical power analysis for the behavioral sciences, 2nd edn. Lawrence Erlbaum Associates, Hillsdale
19.
Zurück zum Zitat Dougherty DD, Rauch SL, Deckersbach T, Marci C, Loh R, Shin LM, Alpert NM, Fischman AJ, Fava M (2004) Ventromedial prefrontal cortex and amygdala dysfunction during an anger induction positron emission tomography study in patients with major depressive disorder with anger attacks. Arch Gen Psychiatry 61:795–804PubMedCrossRef Dougherty DD, Rauch SL, Deckersbach T, Marci C, Loh R, Shin LM, Alpert NM, Fischman AJ, Fava M (2004) Ventromedial prefrontal cortex and amygdala dysfunction during an anger induction positron emission tomography study in patients with major depressive disorder with anger attacks. Arch Gen Psychiatry 61:795–804PubMedCrossRef
20.
Zurück zum Zitat Dougherty DD, Shin LM, Alpert NM, Pitman RK, Orr SP, Lasko M, Macklin ML, Fischman AJ, Rauch SL (1999) Anger in healthy men: a PET study using script-driven imagery. Biol Psychiatry 46:466–472PubMedCrossRef Dougherty DD, Shin LM, Alpert NM, Pitman RK, Orr SP, Lasko M, Macklin ML, Fischman AJ, Rauch SL (1999) Anger in healthy men: a PET study using script-driven imagery. Biol Psychiatry 46:466–472PubMedCrossRef
21.
Zurück zum Zitat Du L, Bakish D, Lapierre YD, Ravindran AV, Hrdina PD (2000) Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder. Am J Med Genet 96:56–60PubMedCrossRef Du L, Bakish D, Lapierre YD, Ravindran AV, Hrdina PD (2000) Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder. Am J Med Genet 96:56–60PubMedCrossRef
22.
Zurück zum Zitat Ellis TE, Berg RA, Franzen MD (1992) Neuropsychological performance and suicidal behavior in adult psychiatric inpatients. Percept Mot Skills 75:639–647PubMedCrossRef Ellis TE, Berg RA, Franzen MD (1992) Neuropsychological performance and suicidal behavior in adult psychiatric inpatients. Percept Mot Skills 75:639–647PubMedCrossRef
23.
Zurück zum Zitat Freedman M (1994) Frontal and parietal lobe dysfunction in depression: delayed alternation and tactile learning deficits. Neuropsychologia 32:1015–1025PubMedCrossRef Freedman M (1994) Frontal and parietal lobe dysfunction in depression: delayed alternation and tactile learning deficits. Neuropsychologia 32:1015–1025PubMedCrossRef
24.
Zurück zum Zitat Freedman M, Black S, Ebert P, Binns M (1998) Orbitofrontal function, object alternation and perseveration. Cereb Cortex 8:18–27PubMedCrossRef Freedman M, Black S, Ebert P, Binns M (1998) Orbitofrontal function, object alternation and perseveration. Cereb Cortex 8:18–27PubMedCrossRef
25.
Zurück zum Zitat Freedman M, Oscar-Berman M (1986) Bilateral frontal lobe disease and selective delayed response deficits in humans. Behav Neurosci 100:337–342PubMedCrossRef Freedman M, Oscar-Berman M (1986) Bilateral frontal lobe disease and selective delayed response deficits in humans. Behav Neurosci 100:337–342PubMedCrossRef
26.
Zurück zum Zitat Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56–62PubMed Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56–62PubMed
27.
Zurück zum Zitat Hampel H, Selg H (1998) FAF. Fragebogen zur Erfassung von Aggressivitätsfraktoren. 2.Auflage. Hogrefe, Göttingen Hampel H, Selg H (1998) FAF. Fragebogen zur Erfassung von Aggressivitätsfraktoren. 2.Auflage. Hogrefe, Göttingen
28.
Zurück zum Zitat Harris EC, Barraclough B (1997) Suicide as an outcome for mental disorders. A meta-analysis. Br J Psychiatry 170:205–228PubMedCrossRef Harris EC, Barraclough B (1997) Suicide as an outcome for mental disorders. A meta-analysis. Br J Psychiatry 170:205–228PubMedCrossRef
29.
Zurück zum Zitat Heila H, Isometsa ET, Henriksson MM, Heikkinen ME, Marttunen MJ, Lonnqvist JK (1997) Suicide and schizophrenia: a nationwide psychological autopsy study on age- and sex-specific clinical characteristics of 92 suicide victims with schizophrenia. Am J Psychiatry 154:1235–1242PubMed Heila H, Isometsa ET, Henriksson MM, Heikkinen ME, Marttunen MJ, Lonnqvist JK (1997) Suicide and schizophrenia: a nationwide psychological autopsy study on age- and sex-specific clinical characteristics of 92 suicide victims with schizophrenia. Am J Psychiatry 154:1235–1242PubMed
30.
Zurück zum Zitat Helmstaedter C, Lendt M, Lux S (2001) Verbaler Lern- und Merkfähgikeitstest. Beltz, Göttingen Helmstaedter C, Lendt M, Lux S (2001) Verbaler Lern- und Merkfähgikeitstest. Beltz, Göttingen
31.
Zurück zum Zitat Horesh N, Rolnick T, Iancu I, Dannon P, Lepkifker E, Apter A, Kotler M (1997) Anger, impulsivity and suicide risk. Psychother Psychosom 66:92–96PubMedCrossRef Horesh N, Rolnick T, Iancu I, Dannon P, Lepkifker E, Apter A, Kotler M (1997) Anger, impulsivity and suicide risk. Psychother Psychosom 66:92–96PubMedCrossRef
32.
Zurück zum Zitat Horn NR, Dolan M, Elliott R, Deakin JF, Woodruff PW (2003) Response inhibition and impulsivity: an fMRI study. Neuropsychologia 41:1959–1966PubMedCrossRef Horn NR, Dolan M, Elliott R, Deakin JF, Woodruff PW (2003) Response inhibition and impulsivity: an fMRI study. Neuropsychologia 41:1959–1966PubMedCrossRef
33.
Zurück zum Zitat Jollant F, Bellivier F, Leboyer M, Astruc B, Torres S, Verdier R, Castelnau D, Malafosse A, Courtet P (2005) Impaired decision making in suicide attempters. Am J Psychiatry 162:304–310PubMedCrossRef Jollant F, Bellivier F, Leboyer M, Astruc B, Torres S, Verdier R, Castelnau D, Malafosse A, Courtet P (2005) Impaired decision making in suicide attempters. Am J Psychiatry 162:304–310PubMedCrossRef
34.
Zurück zum Zitat Kaiser S, Unger J, Kiefer M, Markela J, Mundt C, Weisbrod M (2003) Executive control deficit in depression: event-related potentials in a Go/Nogo task. Psychiatry Res 122:169–184PubMedCrossRef Kaiser S, Unger J, Kiefer M, Markela J, Mundt C, Weisbrod M (2003) Executive control deficit in depression: event-related potentials in a Go/Nogo task. Psychiatry Res 122:169–184PubMedCrossRef
35.
Zurück zum Zitat Keilp JG, Gorlyn M, Oquendo MA, Brodsky B, Ellis SP, Stanley B, John Mann J (2006) Aggressiveness, not impulsiveness or hostility, distinguishes suicide attempters with major depression. Psychol Med 36:1179–1188CrossRef Keilp JG, Gorlyn M, Oquendo MA, Brodsky B, Ellis SP, Stanley B, John Mann J (2006) Aggressiveness, not impulsiveness or hostility, distinguishes suicide attempters with major depression. Psychol Med 36:1179–1188CrossRef
36.
Zurück zum Zitat Keilp JG, Sackeim HA, Brodsky BS, Oquendo MA, Malone KM, Mann JJ (2001) Neuropsychological dysfunction in depressed suicide attempters. Am J Psychiatry 158:735–741PubMedCrossRef Keilp JG, Sackeim HA, Brodsky BS, Oquendo MA, Malone KM, Mann JJ (2001) Neuropsychological dysfunction in depressed suicide attempters. Am J Psychiatry 158:735–741PubMedCrossRef
37.
Zurück zum Zitat King DA, Conwell Y, Cox C, Henderson RE, Denning DG, Caine ED (2000) A neuropsychological comparison of depressed suicide attempters and nonattempters. J Neuropsychiatry Clin Neurosci 12:64–70PubMed King DA, Conwell Y, Cox C, Henderson RE, Denning DG, Caine ED (2000) A neuropsychological comparison of depressed suicide attempters and nonattempters. J Neuropsychiatry Clin Neurosci 12:64–70PubMed
38.
Zurück zum Zitat Lacerda AL, Keshavan MS, Hardan AY, Yorbik O, Brambilla P, Sassi RB, Nicoletti M, Mallinger AG, Frank E, Kupfer DJ, Soares JC (2004) Anatomic evaluation of the orbitofrontal cortex in major depressive disorder. Biol Psychiatry 55:353–358PubMedCrossRef Lacerda AL, Keshavan MS, Hardan AY, Yorbik O, Brambilla P, Sassi RB, Nicoletti M, Mallinger AG, Frank E, Kupfer DJ, Soares JC (2004) Anatomic evaluation of the orbitofrontal cortex in major depressive disorder. Biol Psychiatry 55:353–358PubMedCrossRef
39.
Zurück zum Zitat LeGris J, van Reekum R (2006) The neuropsychological correlates of borderline personality disorder and suicidal behaviour. Can J Psychiatry 51:131–142PubMed LeGris J, van Reekum R (2006) The neuropsychological correlates of borderline personality disorder and suicidal behaviour. Can J Psychiatry 51:131–142PubMed
40.
Zurück zum Zitat Lehrl S (1999) Mehrfachwahl-Wortschatz-Intelligenztest, MWT-B. 4. Auflage. Hofgrefe, Göttingen Lehrl S (1999) Mehrfachwahl-Wortschatz-Intelligenztest, MWT-B. 4. Auflage. Hofgrefe, Göttingen
41.
Zurück zum Zitat Lekka NP, Argyriou AA, Beratis S (2006) Suicidal ideation in prisoners: risk factors and relevance to suicidal behaviour. A prospective case-control study. Eur Arch Psychiatry Clin Neurosci 256:87–92PubMedCrossRef Lekka NP, Argyriou AA, Beratis S (2006) Suicidal ideation in prisoners: risk factors and relevance to suicidal behaviour. A prospective case-control study. Eur Arch Psychiatry Clin Neurosci 256:87–92PubMedCrossRef
42.
Zurück zum Zitat Mann JJ, Waternaux C, Haas GL, Malone KM (1999) Toward a clinical model of suicidal behavior in psychiatric patients. Am J Psychiatry 156:181–189PubMed Mann JJ, Waternaux C, Haas GL, Malone KM (1999) Toward a clinical model of suicidal behavior in psychiatric patients. Am J Psychiatry 156:181–189PubMed
43.
Zurück zum Zitat Marzuk PM, Hartwell N, Leon AC, Portera L (2005) Executive functioning in depressed patients with suicidal ideation. Acta Psychiatr Scand 112:294–301PubMedCrossRef Marzuk PM, Hartwell N, Leon AC, Portera L (2005) Executive functioning in depressed patients with suicidal ideation. Acta Psychiatr Scand 112:294–301PubMedCrossRef
44.
Zurück zum Zitat Meyer TD, Blechert J (2005) Are there attentional deficits in people putatively at risk for affective disorders? J Affect Disord 84:63–72PubMedCrossRef Meyer TD, Blechert J (2005) Are there attentional deficits in people putatively at risk for affective disorders? J Affect Disord 84:63–72PubMedCrossRef
45.
Zurück zum Zitat Mieczkowski TA, Sweeney JA, Haas GL, Junker BW, Brown RP, Mann JJ (1993) Factor composition of the Suicide Intent Scale. Suicide Life Threat Behav 23:37–45PubMed Mieczkowski TA, Sweeney JA, Haas GL, Junker BW, Brown RP, Mann JJ (1993) Factor composition of the Suicide Intent Scale. Suicide Life Threat Behav 23:37–45PubMed
46.
Zurück zum Zitat Must A, Szabo Z, Bodi N, Szasz A, Janka Z, Keri S (2006) Sensitivity to reward and punishment and the prefrontal cortex in major depression. J Affect Disord 90:209–215PubMedCrossRef Must A, Szabo Z, Bodi N, Szasz A, Janka Z, Keri S (2006) Sensitivity to reward and punishment and the prefrontal cortex in major depression. J Affect Disord 90:209–215PubMedCrossRef
47.
Zurück zum Zitat Nangle JM, Clarke S, Morris DW, Schwaiger S, McGhee KA, Kenny N, Murphy K, Gill M, Corvin A, Donohoe G (2006) Neurocognition and suicidal behaviour in an Irish population with major psychotic disorders. Schizophr Res 85:196–200PubMedCrossRef Nangle JM, Clarke S, Morris DW, Schwaiger S, McGhee KA, Kenny N, Murphy K, Gill M, Corvin A, Donohoe G (2006) Neurocognition and suicidal behaviour in an Irish population with major psychotic disorders. Schizophr Res 85:196–200PubMedCrossRef
48.
Zurück zum Zitat Newman JP, Kosson DS (1986) Passive avoidance learning in psychopathic and nonpsychopathic offenders. J Abnorm Psychol 95:252–256PubMedCrossRef Newman JP, Kosson DS (1986) Passive avoidance learning in psychopathic and nonpsychopathic offenders. J Abnorm Psychol 95:252–256PubMedCrossRef
49.
Zurück zum Zitat Patton JH, Stanford MS, Barratt ES (1995) Factor structure of the Barratt impulsiveness scale. J Clin Psychol 51:768–774PubMedCrossRef Patton JH, Stanford MS, Barratt ES (1995) Factor structure of the Barratt impulsiveness scale. J Clin Psychol 51:768–774PubMedCrossRef
50.
Zurück zum Zitat Pollock LR, Williams JM (2004) Problem-solving in suicide attempters. Psychol Med 34:163–167PubMedCrossRef Pollock LR, Williams JM (2004) Problem-solving in suicide attempters. Psychol Med 34:163–167PubMedCrossRef
51.
Zurück zum Zitat Quednow BB, Kuhn KU, Hoppe C, Westheide J, Maier W, Daum I, Wagner M (2007) Elevated impulsivity and impaired decision-making cognition in heavy users of MDMA (“Ecstasy”). Psychopharmacology (Berl) 189:517–530CrossRef Quednow BB, Kuhn KU, Hoppe C, Westheide J, Maier W, Daum I, Wagner M (2007) Elevated impulsivity and impaired decision-making cognition in heavy users of MDMA (“Ecstasy”). Psychopharmacology (Berl) 189:517–530CrossRef
52.
Zurück zum Zitat Raust A, Slama F, Mathieu F, Roy I, Chenu A, Koncke D, Fouques D, Jollant F, Jouvent E, Courtet P, Leboyer M, Bellivier F (2006) Prefrontal cortex dysfunction in patients with suicidal behavior. Psychol Med 37:411–419PubMedCrossRef Raust A, Slama F, Mathieu F, Roy I, Chenu A, Koncke D, Fouques D, Jollant F, Jouvent E, Courtet P, Leboyer M, Bellivier F (2006) Prefrontal cortex dysfunction in patients with suicidal behavior. Psychol Med 37:411–419PubMedCrossRef
53.
Zurück zum Zitat Rey A (1964) L’examen de Clinique en Psychologie. Presses Universitaire de France, Paris Rey A (1964) L’examen de Clinique en Psychologie. Presses Universitaire de France, Paris
54.
Zurück zum Zitat Rogers MA, Kasai K, Koji M, Fukuda R, Iwanami A, Nakagome K, Fukuda M, Kato N (2004) Executive and prefrontal dysfunction in unipolar depression: a review of neuropsychological and imaging evidence. Neurosci Res 50:1–11PubMedCrossRef Rogers MA, Kasai K, Koji M, Fukuda R, Iwanami A, Nakagome K, Fukuda M, Kato N (2004) Executive and prefrontal dysfunction in unipolar depression: a review of neuropsychological and imaging evidence. Neurosci Res 50:1–11PubMedCrossRef
55.
Zurück zum Zitat Schneider B, Wetterling T, Sargk D, Schneider F, Schnabel A, Maurer K, Fritze J (2006) Axis I disorders and personality disorders as risk factors for suicide. Eur Arch Psychiatry Clin Neurosci 256:17–27PubMedCrossRef Schneider B, Wetterling T, Sargk D, Schneider F, Schnabel A, Maurer K, Fritze J (2006) Axis I disorders and personality disorders as risk factors for suicide. Eur Arch Psychiatry Clin Neurosci 256:17–27PubMedCrossRef
56.
Zurück zum Zitat Schotte DE, Cools J, Payvar S (1990) Problem-solving deficits in suicidal patients: trait vulnerability or state phenomenon? J Consult Clin Psychol 58:562–564PubMedCrossRef Schotte DE, Cools J, Payvar S (1990) Problem-solving deficits in suicidal patients: trait vulnerability or state phenomenon? J Consult Clin Psychol 58:562–564PubMedCrossRef
57.
Zurück zum Zitat Tripodianakis J, Markianos M, Rouvali O, Istikoglou C (2007) Gonadal axis hormones in psychiatric male patients after a suicide attempt. Eur Arch Psychiatry Clin Neurosci 257:135–139PubMedCrossRef Tripodianakis J, Markianos M, Rouvali O, Istikoglou C (2007) Gonadal axis hormones in psychiatric male patients after a suicide attempt. Eur Arch Psychiatry Clin Neurosci 257:135–139PubMedCrossRef
58.
Zurück zum Zitat Westheide J, Wagner M, Quednow BB, Hoppe C, Cooper-Mahkorn D, Strater B, Maier W, Kuhn KU (2007) Neuropsychological performance in partly remitted unipolar depressive patients: focus on executive functioning. Eur Arch Psychiatry Clin Neurosci (Epub ahead of print) Westheide J, Wagner M, Quednow BB, Hoppe C, Cooper-Mahkorn D, Strater B, Maier W, Kuhn KU (2007) Neuropsychological performance in partly remitted unipolar depressive patients: focus on executive functioning. Eur Arch Psychiatry Clin Neurosci (Epub ahead of print)
59.
Zurück zum Zitat Zald DH, Curtis C, Folley BS, Pardo JV (2002) Prefrontal contributions to delayed spatial and object alternation: a positron emission tomography study. Neuropsychology 16:182–189PubMedCrossRef Zald DH, Curtis C, Folley BS, Pardo JV (2002) Prefrontal contributions to delayed spatial and object alternation: a positron emission tomography study. Neuropsychology 16:182–189PubMedCrossRef
Metadaten
Titel
Executive performance of depressed suicide attempters: the role of suicidal ideation
verfasst von
Jens Westheide
Boris B. Quednow
Kai-Uwe Kuhn
Christian Hoppe
Déirdre Cooper-Mahkorn
Barbara Hawellek
Petra Eichler
Wolfgang Maier
Michael Wagner
Publikationsdatum
01.10.2008
Verlag
D. Steinkopff-Verlag
Erschienen in
European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 7/2008
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-008-0811-1

Weitere Artikel der Ausgabe 7/2008

European Archives of Psychiatry and Clinical Neuroscience 7/2008 Zur Ausgabe

Demenzkranke durch Antipsychotika vielfach gefährdet

23.04.2024 Demenz Nachrichten

Wenn Demenzkranke aufgrund von Symptomen wie Agitation oder Aggressivität mit Antipsychotika behandelt werden, sind damit offenbar noch mehr Risiken verbunden als bislang angenommen.

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

Bislang gibt es kein Medikament zur Prävention von Wochenbettdepressionen. Das Injektionsanästhetikum Esketamin könnte womöglich diese Lücke füllen.

„Psychotherapie ist auch bei sehr alten Menschen hochwirksam!“

22.04.2024 DGIM 2024 Kongressbericht

Die Kombination aus Medikamenten und Psychotherapie gilt als effektivster Ansatz bei Depressionen. Das ist bei betagten Menschen nicht anders, trotz Besonderheiten.

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

22.04.2024 DGIM 2024 Nachrichten

Um Menschen nach der Flucht aus einem Krisengebiet bestmöglich medizinisch betreuen zu können, ist es gut zu wissen, welche Erkrankungen im jeweiligen Herkunftsland häufig sind. Dabei hilft eine Internetseite der CDC (Centers for Disease Control and Prevention).

Update Psychiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.