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Erschienen in:

01.08.2014

Extracorporeal Membrane Oxygenation and Retransplantation in Lung Transplantation: An Analysis of the UNOS Registry

verfasst von: Don Hayes Jr., Robert S. Higgins, Ahmet Kilic, Stephen Kirkby, Amy L. Pope-Harman, Thomas J. Preston, Bryan A. Whitson

Erschienen in: Lung | Ausgabe 4/2014

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Abstract

Background

Despite limited organ availability, extracorporeal membrane oxygenation (ECMO) and retransplantation are becoming more commonplace.

Methods

Using the United Network for Organ Sharing (UNOS) database, we evaluated survival of patients treated with ECMO before lung transplantation and undergoing retransplantation. A query identified cadaveric recipients from 2001 to 2012 over the age of 6 years.

Results

Of 15,772 lung recipients, 15 583 never received ECMO, whereas 189 did. Mean age was 52.1 ± 14.4 versus 46.8 ± 16.5 years for non-ECMO and ECMO groups, respectively (p < 0.0001). Using Kaplan–Meier method, there were survival differences between ECMO and non-ECMO groups (p < 0.0001) and first-time transplants with and without ECMO to retransplants with and without ECMO (p < 0.0001). The proportional hazards model identified higher risk with ECMO use in idiopathic pulmonary fibrosis (hazard ratio [HR] 1.09; 95 % confidence interval (CI), 1.02–1.17; p = 0.014) and retransplants (HR 1.77; 95 % CI, 1.55–2.03; p < 0.0001).

Conclusions

Survival for retransplantation was similar to ECMO as a primary option with significant mortality associated with ECMO use in patients with idiopathic pulmonary fibrosis and retransplants.

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Titel: Extracorporeal Membrane Oxygenation and Retransplantation in Lung Transplantation: An Analysis of the UNOS Registry
verfasst von: Don Hayes Jr.
Robert S. Higgins
Ahmet Kilic
Stephen Kirkby
Amy L. Pope-Harman
Thomas J. Preston
Bryan A. Whitson
Publikationsdatum: 01.08.2014
Verlag: Springer US
Erschienen in: Lung / Ausgabe 4/2014
Print ISSN: 0341-2040
Elektronische ISSN: 1432-1750
DOI: https://doi.org/10.1007/s00408-014-9593-6

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