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CardioVascular and Interventional Radiology

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01.01.2009 | Laboratory Investigation

FDG-MicroPET and Diffusion-Weighted MR Image Evaluation of Early Changes After Radiofrequency Ablation in Implanted VX2 Tumors in Rabbits

verfasst von: Tomohiro Ohira, Tomohisa Okuma, Toshiyuki Matsuoka, Yasuhiro Wada, Kenji Nakamura, Yasuyoshi Watanabe, Yuichi Inoue

Erschienen in: CardioVascular and Interventional Radiology | Ausgabe 1/2009

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Abstract

The objective of this study was to evaluate the early changes after radiofrequency ablation (RFA) in VX2 rabbit tumors implanted into the back muscles by diffusion-weighted magnetic resonance (MR) imaging and ¹⁸F-2-fluoro-2-deoxy-D-glucose positron emission tomography (¹⁸F-FDG PET). Percutaneous CT-guided RFA was conducted in seven rabbits with implanted VX2 tumors. VX2 tumors on the other side were untreated and served as the control. MR imaging was performed with a clinical 1.5-T instrument 2 days after RFA, and FDG-PET, using a high-resolution PET scanner for small animals, was obtained 3 days after the procedure. The mean apparent diffusion coefficient (ADC) values and radioactivity count of untreated and ablated tumors were calculated. Untreated VX2 tumors showed hyperintensity on T1-, T2-, and diffusion-weighted MR images, ring-enhanced on contrast-enhanced T1-weighted imaging, and ring-shaped FDG accumulation on FDG-PET. Ablated VX2 tumors showed slight hyperintensity on T1-, T2-, and diffusion-weighed images, slight enhancement on contrast-enhanced T1-weighted images, and low accumulation on FDG-PET. The ADC value of ablated VX2 tumors (1.52 ± 0.24 × 10⁻³ mm²/s) was significantly higher than that of untreated tumors (1.09 ± 0.12 × 10⁻³; p < 0.05). The tumor/muscle ratio of ablated tumors (0.5 ± 0.3) was significantly lower than that of untreated tumors (11.6 ± 3.2; p < 0.05). Histopathological examination confirmed the lack of viable tumor cells in the ablated lesions. The results indicate that both ADC value and FDG-PET are potentially useful markers for monitoring the early effects of RFA.

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Titel: FDG-MicroPET and Diffusion-Weighted MR Image Evaluation of Early Changes After Radiofrequency Ablation in Implanted VX2 Tumors in Rabbits
verfasst von: Tomohiro Ohira
Tomohisa Okuma
Toshiyuki Matsuoka
Yasuhiro Wada
Kenji Nakamura
Yasuyoshi Watanabe
Yuichi Inoue
Publikationsdatum: 01.01.2009
Verlag: Springer-Verlag
Erschienen in: CardioVascular and Interventional Radiology / Ausgabe 1/2009
Print ISSN: 0174-1551
Elektronische ISSN: 1432-086X
DOI: https://doi.org/10.1007/s00270-008-9394-5

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