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European Radiology

Erschienen in:

01.02.2021 | Magnetic Resonance

Fetal brain tissue characterization at 1.5 T using STrategically Acquired Gradient Echo (STAGE) imaging

verfasst von: Feifei Qu, Taotao Sun, Yongsheng Chen, Brijesh Kumar Yadav, Ling Jiang, Zhaoxia Qian, E. Mark Haacke

Erschienen in: European Radiology | Ausgabe 8/2021

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Abstract

Objectives

To estimate human fetal brain MRI tissue properties including apparent T₁ (T_1app) and apparent proton density (PD_app) by using a rapid multi-contrast acquisition protocol called STrategically Acquired Gradient Echo (STAGE) imaging.

Methods

STAGE data were collected using two flip angles (15° and 60°, with a TR = 600 ms) for 30 pregnant women at 1.5 T (15 healthy controls: gestational age (GA) range 19 + 1/7 weeks to 34 + 5/7 weeks; 11 abnormal subjects with ventriculomegaly: GA range 21 + 5/7 weeks to 31 + 5/7 weeks; 4 subjects with other abnormalities). Both T_1app and PD_app maps of the fetal brain were calculated from the STAGE data. A region-of-interest-based approach was used to measure T_1app and PD_app in the subplate/intermediate zone (SP/IZ), cortical plate (CP), and cerebrospinal fluid (CSF) in the fetal brain.

Results

The ratios of T_1appSP/IZ/T_1appCP and PD_appSP/IZ/PD_appCP were larger than unity while T_1appSP/IZ/T_1appCSF and PD_appSP/IZ/PD_appCSF were both less than unity.

Conclusions

STAGE imaging provides a potential practical approach to estimate multi-parametric properties of the human fetal brain.

Key Points

• STAGE is feasible in measuring fetal brain tissue properties.

• Water content in cortical plate and subplate/intermediate zone approaches that of cerebrospinal fluid in early gestational ages.

Nur mit Berechtigung zugänglich

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Titel: Fetal brain tissue characterization at 1.5 T using STrategically Acquired Gradient Echo (STAGE) imaging
verfasst von: Feifei Qu
Taotao Sun
Yongsheng Chen
Brijesh Kumar Yadav
Ling Jiang
Zhaoxia Qian
E. Mark Haacke
Publikationsdatum: 01.02.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 8/2021
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-020-07618-7

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Fetal brain tissue characterization at 1.5 T using STrategically Acquired Gradient Echo (STAGE) imaging