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Erschienen in: Clinical Rheumatology 9/2018

16.07.2018 | Review Article

From autoinflammation to autoimmunity: old and recent findings

verfasst von: Francesco Caso, Luisa Costa, Valeria Nucera, Giuseppe Barilaro, Ignazio Francesco Masala, Rossella Talotta, Paolo Caso, Raffaele Scarpa, Piercarlo Sarzi-Puttini, Fabiola Atzeni

Erschienen in: Clinical Rheumatology | Ausgabe 9/2018

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Abstract

Autoimmune diseases and autoinflammatory diseases have a number of similar etiopathogenetic and clinical characteristics, including genetic predisposition and recurrent systemic inflammatory flares. The first phase of ADs involves innate immunity: by means of TLRs, autoantigen presentation, B and T cell recruitment and autoantibody synthesis. The second phase involves adaptive immunity, a self-sustaining process in which immune complexes containing nucleic acids and autoantibodies activate self-directed inflammation. The link between autoimmunity and autoinflammation is IL-1ß, which is crucial in connecting the innate immune response due to NLR activation and the adaptive immune responses of T and B cells. In conclusion, although ADs are still considered adaptive immunity-mediated disorders, there is increasing evidence that innate immunity and inflammasomes are also involved. The aim of this review is to highlight the link between the innate and adaptive immune mechanisms involved in autoimmune diseases.
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Metadaten
Titel
From autoinflammation to autoimmunity: old and recent findings
verfasst von
Francesco Caso
Luisa Costa
Valeria Nucera
Giuseppe Barilaro
Ignazio Francesco Masala
Rossella Talotta
Paolo Caso
Raffaele Scarpa
Piercarlo Sarzi-Puttini
Fabiola Atzeni
Publikationsdatum
16.07.2018
Verlag
Springer London
Erschienen in
Clinical Rheumatology / Ausgabe 9/2018
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-018-4209-9

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