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Calcified Tissue International
Erschienen in: Calcified Tissue International 5/2018

10.10.2017 | Review

From Osteoimmunology to Osteomicrobiology: How the Microbiota and the Immune System Regulate Bone

verfasst von: Emory Hsu, Roberto Pacifici

Erschienen in: Calcified Tissue International | Ausgabe 5/2018

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Abstract

Osteomicrobiology refers to the role of microbiota in bone health and the mechanisms by which the microbiota regulates post-natal skeletal development, bone aging, and pathologic bone loss. Here, we review recent reports linking gut microbiota to changes in bone phenotype. A pro-inflammatory cytokine milieu drives bone resorption in conditions such as sex steroid hormone deficiency. The response of the immune system to activation by the microbiome results in increased circulating osteoclastogenic cytokines in a T cell-dependent mechanism. Additionally, gut microbiota affect bone homeostasis through nutrient absorption, mediation of the IGF-1 pathway, and short chain fatty acid and metabolic products. Manipulation of microbiota through prebiotics or probiotics reduces inflammatory cytokine production, leading to changes in bone density. One mechanism of probiotic action is through upregulating tight junction proteins, increasing the strength of the gut epithelial layer, and leading to less antigen presentation and less activation of intestinal immune cells. Thus, prebiotics or probiotics may represent a future therapeutic avenue for ameliorating the risk of postmenopausal bone loss in humans.
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Metadaten
Titel
From Osteoimmunology to Osteomicrobiology: How the Microbiota and the Immune System Regulate Bone
verfasst von
Emory Hsu
Roberto Pacifici
Publikationsdatum
10.10.2017
Verlag
Springer US
Erschienen in
Calcified Tissue International / Ausgabe 5/2018
Print ISSN: 0171-967X
Elektronische ISSN: 1432-0827
DOI
https://doi.org/10.1007/s00223-017-0321-0

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