nach oben

Erschienen in:

06.04.2017 | Original Article

GABA content within medial prefrontal cortex predicts the variability of fronto-limbic effective connectivity

verfasst von: Stefano Delli Pizzi, Piero Chiacchiaretta, Dante Mantini, Giovanna Bubbico, Richard A. Edden, Marco Onofrj, Antonio Ferretti, Laura Bonanni

Erschienen in: Brain Structure and Function | Ausgabe 7/2017

Einloggen, um Zugang zu erhalten

Abstract

The amygdala-medial prefrontal cortex (mPFC) circuit plays a key role in social behavior. The amygdala and mPFC are bidirectionally connected, functionally and anatomically, via the uncinate fasciculus. Recent evidence suggests that GABA-ergic neurotransmission within the mPFC could be central to the regulation of amygdala activity related to emotions and anxiety processing. However, the functional and neurochemical interactions within amygdala-mPFC circuits are unclear. In the current study, multimodal magnetic resonance imaging techniques were combined to investigate effective connectivity within the amygdala-mPFC network and its relationship with mPFC neurotransmission in 22 healthy subjects aged between 41 and 88 years. Effective connectivity in the amygdala-mPFC circuit was assessed on resting-state functional magnetic resonance imaging data using spectral dynamic causal modelling. State and trait anxiety were also assessed. The mPFC was shown to be the target of incoming outputs from the amygdalae and the source of exciting inputs to the limbic system. The amygdalae were reciprocally connected by excitatory projections. About half of the variance relating to the strength of top–down endogenous connection between right amygdala and mPFC was explained by mPFC GABA levels. State anxiety was correlated with the strength of the endogenous connections between right amygdala and mPFC. We suggest that mPFC GABA content predicts variability in the effective connectivity within the mPFC-amygdala circuit, providing new insights on emotional physiology and the underlying functional and neurochemical interactions.

Nur mit Berechtigung zugänglich

Abbate C, Luzzatti C, Vergani C (2007) Test delle matrici: velocità e accuratezza della ricerca visiva nel corso dell’invecchiamento. G Gerontol 55:11–20

Adhikari A, Lerner TN, Finkelstein J, Pak S, Jennings JH, Davidson TJ, Ferenczi E, Gunaydin LA, Mirzabekov JJ, Ye L, Kim SY, Lei A, Deisseroth K (2015) Basomedial amygdala mediates top-down control of anxiety and fear. Nature 527:179–185. doi:10.1038/nature15698 CrossRefPubMedPubMedCentral

Adolphs R, Damasio H, Tranel D, Damasio A (1996) Cortical systems for the recognition of emotion in facial expressions. J Neurosci 16:7678–7687PubMed

Akirav I, Maroun M (2007) The role of the medial prefrontal cortex-amygdala circuit in stress effects on the extinction of fear. Neural Plast 2007:1–11. doi:10.1155/2007/30873 CrossRef

American Psychiatric Association (2013) Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Association. doi:10.1176/appi.books.9780890425596

Andersen SL, Teicher MH (1999) Serotonin laterality in amygdala predicts performance in the elevated plus maze in rats. NeuroReport 10:3497–3500CrossRefPubMed

Appollonio I, Leone M, Isella V, Piamarta F, Consoli T, Villa ML, Forapani E, Russo A, Nichelli P (2005) The Frontal Assessment Battery (FAB): normative values in an Italian population sample. Neurol Sci 26:108–116. doi:10.1007/s10072-005-0443-4 CrossRefPubMed

Baddeley A, Wilson BA (2002) Prose recall and amnesia: Implications for the structure of working memory. Neuropsychologia 40:1737–1743. doi:10.1016/S0028-3932(01)00146-4 CrossRefPubMed

Baker KB, Kim JJ (2004) Amygdalar lateralization in fear conditioning: evidence for greater involvement of the right amygdala. Behav Neurosci 118:15–23. doi:10.1037/0735-7044.118.1.15 CrossRefPubMed

Bastos-Leite AJ, Ridgway GR, Silveira C, Norton A, Reis S, Friston KJ (2015) Dysconnectivity within the default mode in first-episode schizophrenia: a stochastic dynamic causal modeling study with functional magnetic resonance imaging. Schizophr Bull 41:144–153. doi:10.1093/schbul/sbu080 CrossRefPubMed

Bishop SJ (2007) Neurocognitive mechanisms of anxiety: an integrative account. Trends Cogn Sci 11:307–316. doi:10.1016/j.tics.2007.05.008 CrossRefPubMed

Blair K, Shaywitz J, Smith BW, Rhodes R, Geraci M, Jones M, McCaffrey D, Vythilingam M, Finger E, Jacobs M, Charney DS, Blair RJ, Drevets WC, Pine DS (2008) Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disorders. Am J Psychiatry 165:1193–1202. doi:10.1176/appi.ajp.2008.07071060 CrossRefPubMedPubMedCentral

Bogner W, Gruber S, Doelken M, Stadlbauer A, Ganslandt O, Boettcher U, Trattnig S, Doerfler A, Stefan H, Hammen T (2010) In vivo quantification of intracerebral GABA by single-voxel (1)H-MRS-How reproducible are the results? Eur J Radiol 73:526–531. doi:10.1016/j.ejrad.2009.01.014 CrossRefPubMed

Bonifazi P, Goldin M, Picardo MA, Jorquera I, Cattani A, Bianconi G, Represa A, Ben-Ari Y, Cossart R (2009) GABAergic hub neurons orchestrate synchrony in developing hippocampal networks. Science 326:1419–1424. doi:10.1126/science.1175509 CrossRefPubMed

Bowers D, Blonder LX, Feinberg T, Heilman KM (1991) Differential impact of right and left hemisphere lesions on facial emotion and object imagery. Brain 114:2593–2609. doi:10.1093/brain/114.6.2593 CrossRefPubMed

Bracht T, Tüscher O, Schnell S, Kreher B, Rüsch N, Glauche V, Lieb K, Ebert D, Il’yasov KA, Hennig J, Weiller C, van Elst LT, Saur D (2009) Extraction of prefronto-amygdalar pathways by combining probability maps. Psychiatry Res 174:217–222. doi:10.1016/j.pscychresns.2009.05.001 CrossRefPubMed

Calhoon GG, Tye KM (2015) Resolving the neural circuits of anxiety. Nat Neurosci 18:1394–1404. doi:10.1038/nn.4101 CrossRefPubMed

Canli T, Desmond JE, Zhao Z, Glover G, Gabrieli JDE (1998) Hemispheric asymmetry for emotional stimuli detected with fMRI. NeuroReport 9:3233–3239CrossRefPubMed

Chefer VI, Wang R, Shippenberg TS (2011) Basolateral amygdala-driven augmentation of medial prefrontal cortex GABAergic neurotransmission in response to environmental stimuli associated with cocaine administration. Neuropsychopharmacology 36:2018–2029. doi:10.1038/npp.2011.89 CrossRefPubMedPubMedCentral

Constantinidis C, Williams GV, Goldman-Rakic (2002) A role for inhibition in shaping the temporal flow of information in prefrontal cortex. Nat Neurosci 5:175–180. doi:10.1038/nn799 CrossRefPubMed

Courtin J, Chaudun F, Rozeske RR, Karalis N, Gonzalez-Campo C, Wurtz H, Abdi A, Baufreton J, Bienvenu TC, Herry C (2014) Prefrontal parvalbumin interneurons shape neuronal activity to drive fear expression. Nature 505:92–96. doi:10.1038/nature12755 CrossRefPubMed

Crone JS, Schurz M, Höller Y, Bergmann J, Monti M, Schmid E, Trinka E, Kronbichler M (2015) Impaired consciousness is linked to changes in effective connectivity of the posterior cingulate cortex within the default mode network. Neuroimage 110:101–109. doi:10.1016/j.neuroimage.2015.01.037 CrossRefPubMedPubMedCentral

Crone JS, Lutkenhoff ES, Bio BJ, Laureys S, Monti MM (2017) Testing proposed neuronal models of effective connectivity within the Cortico-basal Ganglia-thalamo-cortical loop during loss of consciousness. Cereb Cortex. doi:10.1093/cercor/bhw112 (In press)

Dale AM, Fischl B, Sereno MI (1999) Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage 9:179–194. doi:10.1006/nimg.1998.0395 CrossRefPubMed

De Bondt T, De Belder F, Vanhevel F, Jacquemyn Y, Parizel PM (2015) Prefrontal GABA concentration changes in women-influence of menstrual cycle phase, hormonal contraceptive use, and correlation with premenstrual symptoms. Brain Res 1597:129–138. doi:10.1016/j.brainres.2014.11.051 CrossRefPubMed

Declaration of Helsinki (1997) Recommendation Guiding Physicians in Biomedical Research involving human subjects. JAMA 277:925–926. doi:10.1001/jama.1997.03540350075038 CrossRef

Delli Pizzi S, Padulo C, Brancucci A, Bubbico G, Edden RA, Ferretti A, Franciotti R, Manippa V, Marzoli D, Onofrj M, Sepede G, Tartaro A, Tommasi L, Puglisi-Allegra S, Bonanni L (2016) GABA content within the ventromedial prefrontal cortex is related to trait anxiety. Soc Cogn Affect Neurosci 11:758–766. doi:10.1093/scan/nsv155 CrossRefPubMed

Delli Pizzi S, Chiacchiaretta P, Mantini D, Bubbico G, Edden RA, Di Giulio C, Onofrj M, Bonanni L (2017) Functional and neurochemical interactions within the amygdala-medial prefrontal cortex circuit and their relevance to emotional processing. Brain Struct Funct. doi:10.1007/s00429-016-1276-z

Donahue MJ, Near J, Blicher JU, Jezzard P (2010) Baseline GABA concentration and fMRI response. Neuroimage 53:392–398. doi:10.1016/j.neuroimage.2010.07.017 CrossRefPubMed

Duncan NW, Enzi B, Wiebking C, Northoff G (2011) Involvement of glutamate in rest-stimulus interaction between perigenual and supragenual anterior cingulate cortex: a combined fMRI-MRS study. Hum Brain Mapp 32:2172–2182. doi:10.1002/hbm.21179 CrossRefPubMed

Duncan NW, Wiebking C, Northoff G (2014) Associations of regional GABA and glutamate with intrinsic and extrinsic neural activity in humans-a review of multimodal imaging studies. Neurosci Biobehav Rev 47:36–52. doi:10.1016/j.neubiorev.2014.07.016 CrossRefPubMed

Edden RA, Barker PB (2007) Spatial effects in the detection of gamma-aminobutyric acid: improved sensitivity at high fields using inner volume saturation. Magn Reson Med 58:1276–1282. doi:10.1002/mrm.21383 CrossRefPubMed

Edden RA, Puts NA, Harris AD, Barker PB, Evans CJ (2014) Gannet: a batch-processing tool for the quantitative analysis of gamma-aminobutyric acid-edited MR spectroscopy spectra. J Magn Reson Imaging 40:1445–1452. doi:10.1002/jmri.24478 CrossRefPubMed

Edden RA, Oeltzschner G, Harris AD, Puts NA, Chan KL, Boer VO, Schär M, Barker PB (2016) Prospective frequency correction for macromolecule-suppressed GABA editing at 3T. J Magn Reson Imaging. doi:10.1002/jmri.25304

Etkin A, Prater KE, Schatzberg AF, Menon V, Greicius MD (2009) Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder. Arch Gen Psychiatry 66:1361–1372. doi:10.1001/archgenpsychiatry.2009.104 CrossRefPubMed

Falkenberg LE, Westerhausen R, Specht K, Hugdahl K (2012) Resting-state glutamate level in the anterior cingulate predicts blood-oxygen level-dependent response to cognitive control. Proc Natl Acad Sci USA 109:5069–5073. doi:10.1073/pnas.1115628109 CrossRefPubMedPubMedCentral

Friston KJ (2011) Functional and effective connectivity: a review. Brain Connect 1:13–36. doi:10.1089/brain.2011.0008 CrossRefPubMed

Friston KJ, Frith CD, Fletcher P, Liddle PF, Frackowiak RSJ (1996) Functional topography: multidimensional scaling and functional connectivity in the brain. Cerebral cortex 6:156–164CrossRefPubMed

Friston KJ, Kahan J, Biswal B, Razi A (2014) A DCM for resting state fMRI. Neuroimage 94:396–407. doi:10.1016/j.neuroimage.2013.12.009 CrossRefPubMedPubMedCentral

Fullana MA, Harrison BJ, Soriano-Mas C, Vervliet B, Cardoner N, Àvila-Parcet A, Radua J (2015) Neural signatures of human fear conditioning: an updated and extended meta-analysis of fMRI studies. Mol Psychiatry 21:500–508. doi:10.1038/mp.2015.88 CrossRefPubMed

Gao F, Edden RA, Li M, Puts NA, Wang H, Bai X, Zhao C, Wang X, Barker PB, Wang H, Bai X, Zhao C, Wang X, Barker PB (2013) Edited magnetic resonance spectroscopy detects an age-related decline in brain GABA levels. Neuroimage 78:75–82. doi:10.1016/j.neuroimage.2013.04.012 CrossRefPubMedPubMedCentral

Ghashghaei HT, Barbas H (2002) Pathways for emotion: interactions of prefrontal and anterior temporal pathways in the amygdala of the rhesus monkey. Neuroscience 115:1261–1279. doi:10.1016/S0306-4522(02)00446-3 CrossRefPubMed

Ghashghaei HT, Hilgetag CC, Barbas H (2007) Sequence of information processing for emotions based on the anatomic dialogue between prefrontal cortex and amygdala. Neuroimage 34:905–923. doi:10.1016/j.neuroimage.2006.09.046 CrossRefPubMed

Giovagnoli AR, Del Pesce M, Mascheroni S, Simoncelli M, Laiacona M, Capitani E (1996) Trail making test: normative values from 287 normal adult controls. Ital J Neurol Sci 17:305–309. doi:10.1007/BF01997792 CrossRefPubMed

Gläscher J, Adolphs R (2003) Processing of the arousal of subliminal and supraliminal emotional stimuli by the human amygdala. J Neurosci 23:10274–10282PubMed

Greenberg T, Carlson JM, Cha J, Hajcak G, Mujica-Parodi LR (2013) Ventromedial prefrontal cortex reactivity is altered in generalized anxiety disorder during fear generalization. Depress Anxiety 30:242–250. doi:10.1002/da.22016 CrossRefPubMed

Groenink L, Joordens RJ, Hijzen TH, Dirks A, Olivier B (2000) Infusion of flesinoxan into the amygdala blocks the fear-potentiated startle. Neuroreport 11:2285–2288CrossRefPubMed

Harris AD, Puts NA, Edden RA (2015) Tissue correction for GABA-edited MRS: considerations of voxel composition, tissue segmentation, and tissue relaxations. J Magn Reson Imaging 42:1431–1440. doi:10.1002/jmri.24903 CrossRefPubMedPubMedCentral

Henry PG, Dautry C, Hantraye P, Bloch G (2001) Brain GABA editing without macromolecule contamination. Magn Reson Med 45:517–520CrossRefPubMed

Horn DI, Yu C, Steiner J, Buchmann J, Kaufmann J, Osoba A, Eckert U, Zierhut KC, Schiltz K, He H, Biswal B, Bogerts B, Walter M (2010) Glutamatergic and resting-state functional connectivity correlates of severity in major depression—the role of pregenual anterior cingulate cortex and anterior insula. Front Syst Neurosci. doi:10.3389/fnsys.2010.00033 PubMedPubMedCentral

Horner MD, Teichner G, Kortte KB, Harvey RT (2002) Construct validity of the Babcock Story recall test. Appl Neuropsychol 9:114–116. doi:10.1207/S15324826AN0902_7 CrossRefPubMed

Jenkinson M, Beckmann CF, Behrens TE, Woolrich MW, Smith SM (2012) FSL. Neuroimage 62:782–790. doi:10.1016/j.neuroimage.2011.09.015 CrossRefPubMed

Johnstone T, van Reekum CM, Urry HL, Kalin NH, Davidson RJ (2007) Failure to regulate: counterproductive recruitment of top-down prefrontal-subcortical circuitry in major depression. J Neurosci 27:8877–8884. doi:10.1523/JNEUROSCI.2063-07.2007 CrossRefPubMed

Kapogiannis D, Reiter DA, Willette AA, Mattson MP (2013) Posteromedial cortex glutamate and GABA predict intrinsic functional connectivity of the default mode network. Neuroimage 64:112–119. doi:10.1016/j.neuroimage.2012.09.029 CrossRefPubMed

Kim H, Somerville LH, Johnstone T, Alexander AL, Whalen PJ (2003) Inverse amygdala and medial prefrontal cortex responses to surprised faces. Neuroreport 14:2317–2322. doi:10.1097/01.wnr.0000101520.44335.20 CrossRefPubMed

Kim MJ, Loucks RA, Palmer AL, Brown AC, Solomon KM, Marchante AN, Whalen PJ (2011) The structural and functional connectivity of the amygdala: from normal emotion to pathological anxiety. Behav Brain Res 223:403–410. doi:10.1016/j.bbr.2011.04.025 CrossRefPubMedPubMedCentral

Kragel PA, LaBar KS (2016) Decoding the Nature of Emotion in the Brain. Trends Cogn Sci 20:444–455. doi:10.1016/j.tics.2016.03.011 CrossRefPubMedPubMedCentral

Krettek JE, Price JL (1978) A description of the amygdaloid complex in the rat and cat with observations on intra-amygdaloid axonal connections. J Comp Neurol 178:255–280. doi:10.1002/cne.901780205 CrossRefPubMed

Li B, Daunizeau J, Stephan KE, Penny W, Hu D, Friston K (2011) Generalised filtering and stochastic DCM for fMRI. Neuroimage 58:442–457. doi:10.1016/j.neuroimage.2011.01.085 CrossRefPubMed

Likhtik E, Pelletier JG, Paz R, Paré D (2005) Prefrontal control of the amygdala. J Neurosci 25:7429–7437. doi:10.1523/JNEUROSCI.2314-05.2005 CrossRefPubMed

Magni E, Binetti G, Bianchetti A, Rozzini R, Trabucchil M (1996a) Mini-Mental State Examination: a normative study in Italian elderly population. Eur J Neurol 3:198–202. doi:10.1111/j.1468-1331.1996.tb00423.x CrossRefPubMed

Makovac E, Meeten F, Watson DR, Herman A, Garfinkel SN, D Critchley H, Ottaviani C (2016) Alterations in amygdala-prefrontal functional connectivity account for excessive worry and autonomic dysregulation in generalized anxiety disorder. Biol Psychiatry 80:786–795. doi:10.1016/j.biopsych.2015.10.013 CrossRefPubMed

Mandal MK, Tandon SC, Asthana HS (1991) Right brain damage impairs recognition of negative emotions. Cortex 27:247–253CrossRefPubMed

Markowitsch HJ (1998) Differential contribution of right and left amygdala to affective information processing. Behavioral. Neurology 11:233–244

McDonald AJ (1998) Cortical pathways to the mammalian amygdala. Prog Neurobiol 55:257–332. doi:10.1016/S0301-0082(98)00003-3 CrossRefPubMed

McKlveen JM, Morano RL, Fitzgerald M, Zoubovsky S, Cassella SN, Scheimann JR, Ghosal S, Mahbod P, Packard BA, Myers B, Baccei ML, Herman JP (2016) Chronic stress increases prefrontal inhibition: a mechanism for stress-induced prefrontal dysfunction. Biol Psychiatry 80(10):754–764. doi:10.1016/j.biopsych.2016.03.2101 CrossRefPubMed

Mochcovitch MD, da Rocha Freire RC, Garcia RF, Nardi AE (2014) A systematic review of fMRI studies in generalized anxiety disorder: evaluating its neural and cognitive basis. J Affect Disord 167:336–342. doi:10.1016/j.jad.2014.06.041 CrossRefPubMed

Moscarello JM, LeDoux JE (2013) Active avoidance learning requires prefrontal suppression of amygdala-mediated defensive reactions. J Neurosci 33:3815–3823. doi:10.1523/JNEUROSCI.2596-12.2013 CrossRefPubMedPubMedCentral

Mullins PG, McGonigle DJ, O’Gorman RL, Puts NA, Vidyasagar R, Evans CJ, Edden RA (2014) Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA. Neuroimage 86:43–52. doi:10.1016/j.neuroimage.2012.12.004 CrossRefPubMed

Muthukumaraswamy SD, Evans CJ, Edden RA, Wise RG, Singh KD (2012) Individual variability in the shape and amplitude of the BOLD-HRF correlates with endogenous GABAergic inhibition. Hum Brain Mapp 33:455–465. doi:10.1002/hbm.21223 CrossRefPubMed

Near J, Edden R, Evans CJ, Paquin R, Harris A, Jezzard P (2015) Frequency and phase drift correction of magnetic resonance spectroscopy data by spectral registration in the time domain. Magn Reson Med 73:44–50. doi:10.1002/mrm.25094 CrossRefPubMed

Northoff G, Walter M, Schulte RF, Beck J, Dydak U, Henning A, Boeker H, Grimm S, Boesiger P (2007) GABA concentrations in the human ACC predict negative BOLD responses in fMRI. Nat Neurosci 10:1515–1517. doi:10.1038/nn2001 CrossRefPubMed

Nuss P (2015) Anxiety disorders and GABA neurotransmission: a disturbance of modulation. Neuropsychiatr Dis Treat 11:165–175. doi:10.2147/NDT.S58841 PubMedPubMedCentral

Ochsner KN, Knierim K, Ludlow DH, Hanelin J, Ramachandran T, Glover G, Mackey SC (2004) Reflecting upon feelings: an fMRI study of neural systems supporting the attribution of emotion to self and other. J Cogn Neurosci 16:1746–1772. doi:10.1162/0898929042947829 CrossRefPubMed

Oppenheimer DM (2008) The secret life of fluency. Trends Cogn Sci 12:237–241. doi:10.1016/j.tics.2008.02.014 CrossRefPubMed

Palomero-Gallagher N, Mohlberg H, Zilles K, Vogt B (2008) Cytology and receptor architecture of human anterior cingulate cortex. J Comp Neurol 508:906–926. doi:10.1002/cne.21684 CrossRefPubMedPubMedCentral

Palomero-Gallagher N, Zilles K, Schleicher A, Vogt BA (2013) Cyto- and receptor architecture of area 32 in human and macaque brains. J Comp Neurol 521:3272–3286. doi:10.1002/cne.23346 CrossRefPubMed

Phillips ML, Ladouceur CD, Drevets WC (2008) A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder. Mol Psychiatry 13:833–857. doi:10.1038/mp.2008.65 CrossRef

Power JD, Barnes KA, Snyder AZ, Schlaggar BL, Petersen SE (2012) Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Neuroimage 59:2142–2154. doi:10.1016/j.neuroimage.2011.10.018 CrossRefPubMed

Quirk GJ, Gehlert DR (2003) Inhibition of the amygdala: key to pathological states? Ann N Y Acad Sci 985:263–272. doi:10.1111/j.1749-6632.2003.tb07087.x CrossRefPubMed

Rae CD (2014) A guide to the metabolic pathways and function of metabolites observed in human brain 1 H magnetic resonance spectra. Neurochem Res 39:1–36. doi:10.1007/s11064-013-1199-5 CrossRefPubMed

Razi A, Kahan J, Rees G, Friston KJ (2015) Construct validation of a DCM for resting state fMRI. Neuroimage 106:1–14. doi:10.1016/j.neuroimage.2014.11.027 CrossRefPubMedPubMedCentral

Robinson OJ, Charney DR, Overstreet C, Vytal K, Grillon C (2012) The adaptive threat bias in anxiety: amygdala-dorsomedial prefrontal cortex coupling and aversive amplification. Neuroimage 60:523–529. doi:10.1016/j.neuroimage.2011 CrossRefPubMed

Rothman DL, Behar KL, Prichard JW, Petroff OA (1997) Homocarnosine and the measurement of neuronal pH in patients with epilepsy. Magn Reson Med 38:924–929. doi:10.1002/mrm.1910380611 CrossRefPubMed

Roy AK, Shehzad Z, Margulies DS, Kelly AM, Uddin LQ, Gotimer K, Biswal BB, Castellanos FX, Milham MP (2009) Functional connectivity of the human amygdala using resting state fMRI. Neuroimage 45:614–626. doi:10.1016/j.neuroimage.2008.11.030 CrossRefPubMed

Rule RR, Shimamura AP, Knight RT (2002) Orbitofrontal cortex and dynamic filtering of emotional stimuli. Cogn Affect Behav Neurosci 2:264–270. doi:10.3758/CABN.2.3.264 CrossRefPubMed

Russchen FT (1982) Amygdalopetal projections in the cat. I. Cortical afferent connections. A study with retrograde and anterograde tracing techniques. J Comp Neurol 206:159–179CrossRefPubMed

Sergerie K, Chochol C, Armony JL (2008) The role of the amygdala in emotional processing: a quantitative meta-analysis of functional neuroimaging studies. Neurosci Biobehav Rev 32:811–830. doi:10.1016/j.neubiorev.2007.12.002 CrossRefPubMed

Sesack SR, Deutch AY, Roth RH, Bunney BS (1989) Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: an anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin. J Comp Neurol 290:213–242CrossRefPubMed

Shin MS, Park SY, Park SR, Seol SH, Kwon JS (2006) Clinical and empirical applications of the Rey-Osterrieth Complex Figure Test. Nat Protoc 1:892–899. doi:10.1038/nprot.2006.115 CrossRefPubMed

Sladky R, Höflich A, Küblböck M, Kraus C, Baldinger P, Moser E, Lanzenberger R, Windischberger C (2015) Disrupted effective connectivity between the amygdala and orbitofrontal cortex in social anxiety disorder during emotion discrimination revealed by dynamic causal modeling for fMRI. Cereb Cortex 25:895–903. doi:10.1093/cercor/bht279 CrossRefPubMed

Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TE, Johansen-Berg H, Bannister PR, De Luca M, Drobnjak I, Flitney DE, Niazy RK, Saunders J, Vickers J, Zhang Y, De Stefano N, Brady JM, Matthews PM (2004) Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 23:S208–S219. doi:10.1016/j.neuroimage.2004.07.051 CrossRefPubMed

Somerville LH, Wagner DD, Wig GS, Moran JM, Whalen PJ, Kelley WM (2013) Interactions between transient and sustained neural signals support the generation and regulation of anxious emotion. Cereb Cortex 23:49–60. doi:10.1093/cercor/bhr373 CrossRefPubMed

Spielberger CD (1983) Manual for the state–trait anxiety inventory STAI (Form Y). Mind Garden, Palo Alto

Stagg CJ, Bachtiar V, Amadi U, Gudberg CA, Ilie AS, Sampaio-Baptista C, O'Shea J, Woolrich M, Smith SM, Filippini N, Near J, Johansen-Berg H (2014) Local GABA concentration is related to network-level resting functional connectivity. eLife 3:e01465. doi:10.7554/eLife.01465

Taylor JM, Whalen PJ (2015) Neuroimaging and anxiety: the neural substrates of pathological and non-pathological anxiety. Curr Psychiatry Rep 17:49. doi:10.1007/s11920-015-0586-9 CrossRefPubMed

Urry HL, van Reekum CM, Johnstone T, Kalin NH, Thurow ME, Schaefer HS, Jackson CA, Frye CJ, Greischar LL, Alexander AL, Davidson RJ (2006) Amygdala and ventromedial prefrontal cortex are inversely coupled during regulation of negative affect and predict the diurnal pattern of cortisol secretion among older adults. J Neurosci 26:4415–4425. doi:10.1523/JNEUROSCI.3215-05.2006 CrossRefPubMed

Wechsler D (1939) The measurement of adult intelligence. Williams & Wilkins Co, Baltimore

Wright CI, Martis B, Schwartz CE, Shin LM, Fischer HH, McMullin K et al (2003) Novelty responses and differential effects of order in the amygdala, substantia innominata, and inferior temporal cortex. Neuroimage 18:660–669CrossRefPubMed

Zald DH, Donndelinger MJ, Pardo JV (1998) Elucidating dynamic brain interactions with across-subjects correlational analyses of positron emission tomographic data: the functional connectivity of the amygdala and orbitofrontal cortex during olfactory tasks. J Cereb Blood Flow 18:896–905CrossRef

Titel: GABA content within medial prefrontal cortex predicts the variability of fronto-limbic effective connectivity
verfasst von: Stefano Delli Pizzi
Piero Chiacchiaretta
Dante Mantini
Giovanna Bubbico
Richard A. Edden
Marco Onofrj
Antonio Ferretti
Laura Bonanni
Publikationsdatum: 06.04.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Brain Structure and Function / Ausgabe 7/2017
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-017-1399-x

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Viel Bewegung in der Parkinsonforschung

25.04.2024 Parkinson-Krankheit Nachrichten

Neue arznei- und zellbasierte Ansätze, Frühdiagnose mit Bewegungssensoren, Rückenmarkstimulation gegen Gehblockaden – in der Parkinsonforschung tut sich einiges. Auf dem Deutschen Parkinsonkongress ging es auch viel um technische Innovationen.

Demenzkranke durch Antipsychotika vielfach gefährdet

23.04.2024 Demenz Nachrichten

Wenn Demenzkranke aufgrund von Symptomen wie Agitation oder Aggressivität mit Antipsychotika behandelt werden, sind damit offenbar noch mehr Risiken verbunden als bislang angenommen.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 7/2017

Hilar granule cells of the mouse dentate gyrus: effects of age, septotemporal location, strain, and selective deletion of the proapoptotic gene BAX

Immunohistochemical and biochemical evidence for the presence of serotonin-containing neurons and nerve fibers in the octopus arm

MicroRNAs contribute to postnatal development of laminar differences and neuronal subtypes in the rat medial entorhinal cortex

Melatonin receptors: distribution in mammalian brain and their respective putative functions

Behavioral inhibition system sensitivity enhances motor cortex suppression when watching fearful body expressions