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01.08.2015 | Gastrointestinal

Gadoxetic acid-enhanced MRI and diffusion-weighted imaging for the detection of colorectal liver metastases after neoadjuvant chemotherapy

verfasst von: Mi Hye Yu, Jeong Min Lee, Bo Yun Hur, Tae-You Kim, Seung-Yong Jeong, Nam-Joon Yi, Kyung-Suk Suh, Joon Koo Han, Byung-Ihn Choi

Erschienen in: European Radiology | Ausgabe 8/2015

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Abstract

Objectives

To investigate the diagnostic performance of gadoxetic acid-enhanced MRI including diffusion-weighted imaging (DWI) for the detection of colorectal liver metastases (CRLMs) after neoadjuvant chemotherapy (NAC).

Methods

Our study population comprised 77 patients with 140 CRLMs who underwent gadoxetic acid-enhanced MRI within 1 month prior to surgery: group A (without NAC, n = 38) and group B (with NAC, n = 39). Two radiologists independently assessed all MR images and graded their diagnostic confidence for CRLM on a 5-point scale. Diagnostic accuracy, sensitivity and positive predictive values (PPV) were calculated and compared between the two groups.

Results

Diagnostic accuracy of gadoxetic acid-enhanced MRI in group B was slightly lower than in group A, but a statistically significant difference was not observed (observer 1: A _z, 0.926 in group A, 0.905 in group B; observer 2: A _z, 0.944 in group A, 0.885 in group B; p > 0.05). Sensitivity and PPV of group B were comparable to those of group A (observer 1: sensitivity = 93.5 % vs. 93.6 %, PPV = 95.1 % vs. 86.9 %; observer 2: sensitivity = 96.8 % vs. 91.0 %; PPV = 90.0 % vs. 89.7 %; all p > 0.05).

Conclusions

Gadoxetic acid-enhanced MRI including DWI provided good diagnostic performance with high sensitivity (>90 %) for the detection of CRLMs, regardless of the influence of NAC.

Key Points

• Gadoxetic acid-enhanced MRI including DWI shows high sensitivity for CRLMs.

• Chemotherapy does not influence the diagnostic performance of liver MRI for CRLMs.

• Gadoxetic acid-enhanced MRI can be used for evaluation of CRLMs after NAC.

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Titel: Gadoxetic acid-enhanced MRI and diffusion-weighted imaging for the detection of colorectal liver metastases after neoadjuvant chemotherapy
verfasst von: Mi Hye Yu
Jeong Min Lee
Bo Yun Hur
Tae-You Kim
Seung-Yong Jeong
Nam-Joon Yi
Kyung-Suk Suh
Joon Koo Han
Byung-Ihn Choi
Publikationsdatum: 01.08.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 8/2015
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-3615-5

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Gadoxetic acid-enhanced MRI and diffusion-weighted imaging for the detection of colorectal liver metastases after neoadjuvant chemotherapy