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Metabolic Brain Disease

Erschienen in:

02.06.2017 | Original Article

Gallic acid and p-coumaric acid attenuate type 2 diabetes-induced neurodegeneration in rats

verfasst von: Adel Abdel-Moneim, Ahmed I. Yousef, Sanaa M. Abd El-Twab, Eman S. Abdel Reheim, Mohamed B. Ashour

Erschienen in: Metabolic Brain Disease | Ausgabe 4/2017

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Abstract

The brain of diabetics revealed deterioration in many regions, especially the hippocampus. Hence, the present study aimed to evaluate the effects of gallic acid and p-coumaric acid against the hippocampal neurodegeneration in type 2 diabetic rats. Adult male albino rats were randomly allocated into four groups: Group 1 served as control ones and others were induced with diabetes. Group 2 considered as diabetic, and groups 3 and 4 were further orally treated with gallic acid (20 mg/kg b.wt./day) and p-coumaric acid (40 mg/kg b.wt./day) for six weeks. Diabetic rats revealed significant elevation in the levels of serum glucose, blood glycosylated hemoglobin and serum tumor necrosis factor-α, while the level of serum insulin was significantly declined. Furthermore, the brain of diabetic rats showed a marked increase in oxidative stress and a decrease of antioxidant parameters as well as upregulation the protein expression of Bax and downregulation the protein expression of Bcl-2 in the hippocampus. Treatment of diabetic rats with gallic acid and p-coumaric acid significantly ameliorated glucose tolerance, diminished the brain oxidative stress and improved antioxidant status, declined inflammation and inhibited apoptosis in the hippocampus. The overall results suggested that gallic acid and p-coumaric acid may inhibit hippocampal neurodegeneration via their potent antioxidant, anti-inflammatory and anti-apoptotic properties. Therefore, both compounds can be recommended as hopeful adjuvant agents against brain neurodegeneration in diabetics.

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Titel: Gallic acid and p-coumaric acid attenuate type 2 diabetes-induced neurodegeneration in rats
verfasst von: Adel Abdel-Moneim
Ahmed I. Yousef
Sanaa M. Abd El-Twab
Eman S. Abdel Reheim
Mohamed B. Ashour
Publikationsdatum: 02.06.2017
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 4/2017
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-017-0039-8

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