Background
Methods
Study Participants
Aβ PET acquisition
Aβ PET quantification using centiloid values
Thigh muscle mass measurement
Thigh fat mass measurement
Standardized neuropsychological test battery
Statistical analyses
Results
Clinical characteristics of participants
Variables | Males | Females | ||||
---|---|---|---|---|---|---|
Total (n = 134) | Aβ (−) (n = 90) | Aβ (+) (n = 44) | Total (n= 106) | Aβ (−) (n = 65) | Aβ (+) (n = 41) | |
Cognitive stage | ||||||
NC | 62 (46.3%) | 49 (54.4%)∗ | 13 (29.5%)∗ | 61 (57.5%) | 43 (66.2%)∗ | 18 (43.9%)∗ |
MCI | 72 (53.7%) | 41 (45.6%)∗ | 31 (70.5%)∗ | 45 (42.5%) | 22 (33.8%)∗ | 23 (56.1%)∗ |
Demographics | ||||||
Age, years | 71.3±6.7 | 70.5±7.2∗ | 72.8±5.3∗ | 69.9±8.1 | 68.9±8.3 | 71.5±7.5 |
Education, years | 13.7±4.0 | 14.2±3.5 | 12.8±4.6 | 12.0±4.8 | 12.4±4.7 | 11.2±4.9 |
APOE, e4 carrier | 47 (35.1%) | 19 (21.1%)∗ | 28 (63.6%)∗ | 33 (31.1%) | 10 (15.4%)∗ | 23 (56.1%)∗ |
Hypertension | 64 (47.8%) | 46 (51.1%) | 18 (40.9%) | 49 (46.2%) | 29 (44.6%) | 20 (48.8%) |
Diabetes | 32 (23.9%) | 23 (25.6%) | 9 (20.5%) | 17 (16.0%) | 11 (16.9%) | 6 (14.6%) |
Body composition | ||||||
BMI, kg/m2 | 24.0±2.6 | 24.56±2.57∗ | 22.85±2.41∗ | 23.5±2.9 | 24.01±2.91∗ | 22.69±2.84∗ |
LASMI, kg/m2 | 5.57±0.47 | 5.62±0.50 | 5.48±0.39 | 4.64±0.44 | 4.72±0.42∗ | 4.50±0.44∗ |
GFFP, % | 18.72±4.05 | 19.48±4.02∗ | 17.15±3.66∗ | 25.19±4.54 | 25.28±4.08 | 25.05±5.24 |
Aβ deposition | ||||||
Centiloid | 27.0±42.1 | 1.3±6.7∗ | 79.6±34.2∗ | 27.1±37.1 | 2.2±6.3∗ | 66.4±30.9∗ |
Cognitive tests | ||||||
SVLT recall | 4.4±2.9 | 5.2±2.9∗ | 2.9±2.3∗ | 5.2±3.4 | 6.1±3.1∗ | 3.5±3.2∗ |
RCFT recall | 13.2±6.9 | 15.0±7.0∗ | 9.7±5.1∗ | 11.0±6.9 | 13.0±6.7∗ | 7.8±6.1∗ |
K-BNT | 46.7±7.8 | 47.7±7.3∗ | 44.7±8.5∗ | 43.3±9.7 | 45.1±8.6∗ | 40.3±10.8∗ |
RCFT copying | 32.2±4.5 | 32.9±3.1∗ | 30.7±6.2∗ | 30.4±7.2 | 31.7±5.7∗ | 28.3±8.8∗ |
DSB | 3.9±1.0 | 3.9±1.0 | 3.9±1.0 | 3.9±1.4 | 4.1±1.5 | 3.7±1.3 |
Stroop CR | 73.0±24.9 | 76.1±23.0∗ | 66.8±27.6∗ | 80.5±28.5 | 88.0±25.7∗ | 68.0±28.7∗ |
Effect of BMI on Aβ uptakes
Effects of body composition on Aβ uptakes
Males | Females | |||||
---|---|---|---|---|---|---|
OR (95%CI)a | p | OR (95%CI)a | p | p for interaction by genderb | ||
Muscle | LASMI | 0.49 (0.16–1.40) | 0.192 | 0.27 (0.08–0.83) | 0.031 | 0.810 |
Fat | GFFP | 0.84 (0.73–0.95) | 0.008 | 0.98 (0.89–1.10) | 0.870 | 0.075 |