nach oben

Erschienen in:

29.03.2018 | Original Contribution

Higher serum carotenoids associated with improvement of non-alcoholic fatty liver disease in adults: a prospective study

verfasst von: Mian-li Xiao, Geng-dong Chen, Fang-fang Zeng, Rui Qiu, Wen-qi Shi, Jie-sheng Lin, Yi Cao, Hua-bin Li, Wen-hua Ling, Yu-ming Chen

Erschienen in: European Journal of Nutrition | Ausgabe 2/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Previous studies have suggested that serum carotenoids might be inversely associated with non-alcoholic fatty liver disease (NAFLD), but little data came from longitudinal studies. We prospectively examined the associations between serum-carotenoid levels and NAFLD severity and the intermediary effects of retinol-binding protein 4 (RBP4), HOMA insulin-resistance index (HOMA-IR), body mass index (BMI), and serum triglycerides in middle-aged and elderly Chinese adults.

Methods

This prospective study included 3336 Chinese adults (40–75 years). We assessed serum concentrations of carotenoids at baseline and determined serum RBP4, triglycerides, and HOMA-IR levels at year 3. Abdominal ultrasonography was conducted to assess the presence and degree of NAFLD at years 3 and 6.

Results

The 2687 subjects who completed both NAFLD tests were classified into stable, improved and progressed groups according to changes in the degree of NAFLD between two visits. Analyses of covariance showed that ln-transformed serum concentrations of α-carotene, β-cryptoxanthin, β-carotene, lycopene, lutein/zeaxanthin, and total carotenoids were positively associated with NAFLD improvement (all p-trend < 0.05). After multivariable adjustment, mean differences in serum carotenoids were higher by 29.6% (β-carotene), 18.2% (α-carotene), 15.6% (β-cryptoxanthin), 11.5% (lycopene), 8.9% (lutein/zeaxanthin), and 16.6% (total carotenoids) in the improved vs. progressed subjects. Path analyses indicated the carotenoid–NAFLD association was mediated by lowering serum RBP4, triglycerides, HOMA-IR, and BMI, which were positively associated with the prevalence and progression of NAFLD.

Conclusions

In middle-aged and elderly adults, higher serum-carotenoid concentrations were favorably associated with NAFLD improvement, mediated by reducing serum RBP4, triglycerides, HOMA-IR, and BMI.

Trial registrations

This study has been registered at http://www.clinicaltrials.gov as NCT03179657.

Nur mit Berechtigung zugänglich

Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, Charlton M, Sanyal AJ (2012) The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology 142:1592–1609. https://doi.org/10.1053/j.gastro.2012.04.001 CrossRef

Starley BQ, Calcagno CJ, Harrison SA (2010) Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection. Hepatology 51:1820–1832. https://doi.org/10.1002/hep.23594 CrossRefPubMed

Li S, Tan HY, Wang N, Zhang ZJ, Lao L, Wong CW, Feng Y (2015) The role of oxidative stress and antioxidants in liver diseases. Int J Mol Sci 16:26087–26124. https://doi.org/10.3390/ijms161125942 CrossRefPubMedPubMedCentral

Salomone F, Godos J, Zelber-Sagi S (2016) Natural antioxidants for non-alcoholic fatty liver disease: molecular targets and clinical perspectives. Liver Int 36:5–20. https://doi.org/10.1111/liv.12975 CrossRefPubMed

Johnson EJ (2002) The role of carotenoids in human health. Nutr Clin Care 5:56–65. https://doi.org/10.1046/j.1523-5408.2002.00004.x CrossRefPubMed

Marcotorchino J, Romier B, Gouranton E, Riollet C, Gleize B, Malezet-Desmoulins C, Landrier JF (2012) Lycopene attenuates LPS-induced TNF-alpha secretion in macrophages and inflammatory markers in adipocytes exposed to macrophage-conditioned media. Mol Nutr Food Res 56:725–732. https://doi.org/10.1002/mnfr.201100623 CrossRefPubMed

Yilmaz B, Sahin K, Bilen H, Bahcecioglu IH, Bilir B, Ashraf S, Halazun KJ, Kucuk O (2015) Carotenoids and non-alcoholic fatty liver disease. Hepatobiliary Surg Nutr 4:161–171. https://doi.org/10.3978/j.issn.2304-3881.2015.01.11 CrossRefPubMedPubMedCentral

Palozza P, Simone R, Catalano A, Boninsegna A, Bohm V, Frohlich K, Mele MC, Monego G, Ranelletti FO (2010) Lycopene prevents 7-ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophages. J Nutr Biochem 21:34–46. https://doi.org/10.1016/j.jnutbio.2008.10.002 CrossRefPubMed

Jiang W, Guo MH, Hai X (2016) Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat. World J Gastroenterol 22:10180–10188. https://doi.org/10.3748/wjg.v22.i46.10180 CrossRefPubMedPubMedCentral

10.

Bonet ML, Canas JA, Ribot J, Palou A (2015) Carotenoids and their conversion products in the control of adipocyte function, adiposity and obesity. Arch Biochem Biophys 572:112–125. https://doi.org/10.1016/j.abb.2015.02.022 CrossRefPubMed

11.

Blondin SA, Yeung EH, Mumford SL, Zhang C, Browne RW, Wactawski-Wende J, Schisterman EF (2013) Serum retinol and carotenoids in association with biomarkers of insulin resistance among premenopausal women. ISRN Nutr 2013:619516. https://doi.org/10.5402/2013/619516 CrossRefPubMed

12.

Riso P, Visioli F, Grande S, Guarnieri S, Gardana C, Simonetti P, Porrini M (2006) Effect of a tomato-based drink on markers of inflammation, immunomodulation, and oxidative stress. J Agric Food Chem 54:2563–2566. https://doi.org/10.1021/jf053033c CrossRefPubMed

13.

Murillo AG, DiMarco DM, Fernandez ML (2016) The potential of non-provitamin a carotenoids for the prevention and treatment of non-alcoholic fatty liver disease. Biology. https://doi.org/10.3390/biology5040042 CrossRefPubMedPubMedCentral

14.

Cao Y, Wang C, Liu J, Liu ZM, Ling WH, Chen YM (2015) Greater serum carotenoid levels associated with lower prevalence of nonalcoholic fatty liver disease in Chinese adults. Sci Rep 5:12951. https://doi.org/10.1038/srep12951 CrossRefPubMedPubMedCentral

15.

Ruhl CE, Everhart JE (2003) Relation of elevated serum alanine aminotransferase activity with iron and antioxidant levels in the United States. Gastroenterology 124:1821–1829. https://doi.org/10.1016/s0016-5085(03)00395-0 CrossRefPubMed

16.

Erhardt A, Stahl W, Sies H, Lirussi F, Donner A, Haussinger D (2011) Plasma levels of vitamin E and carotenoids are decreased in patients with nonalcoholic steatohepatitis (NASH). Eur J Med Res 16:76–78. https://doi.org/10.1186/2047-783X-16-2-76 CrossRefPubMedPubMedCentral

17.

Villaca Chaves G, Pereira SE, Saboya CJ, Ramalho A (2008) Non-alcoholic fatty liver disease and its relationship with the nutritional status of vitamin A in individuals with class III obesity. Obes Surg 18:378–385. https://doi.org/10.1007/s11695-007-9361-2 CrossRefPubMed

18.

Miranda-Vilela AL, Akimoto AK, Alves PC, Pereira LC, Goncalves CA, Klautau-Guimaraes MN, Grisolia CK (2009) Dietary carotenoid-rich pequi oil reduces plasma lipid peroxidation and DNA damage in runners and evidence for an association with MnSOD genetic variant -Val9Ala. Genet Mol Res 8:1481–1495. https://doi.org/10.4238/vol8-4gmr684 CrossRefPubMed

19.

Sugiura M, Nakamura M, Ogawa K, Ikoma Y, Yano M (2016) High serum carotenoids are associated with lower risk for developing elevated serum alanine aminotransferase among Japanese subjects: the Mikkabi cohort study. Br J Nutr 115:1462–1469. https://doi.org/10.1017/s0007114516000374 CrossRefPubMed

20.

Tiniakos DG, Vos MB, Brunt EM (2010) Nonalcoholic fatty liver disease: pathology and pathogenesis. Annu Rev Pathol 5:145–171. https://doi.org/10.1146/annurev-pathol-121808-102132 CrossRef

21.

Schwenzer NF, Springer F, Schraml C, Stefan N, Machann J, Schick F (2009) Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance. J Hepatol 51:433–445. https://doi.org/10.1016/j.jhep.2009.05.023 CrossRefPubMed

22.

Liu J, Shi WQ, Cao Y, He LP, Guan K, Ling WH, Chen YM (2014) Higher serum carotenoid concentrations associated with a lower prevalence of the metabolic syndrome in middle-aged and elderly Chinese adults. Br J Nutr 112:2041–2048. https://doi.org/10.1017/s000711451400316x CrossRefPubMed

23.

Liu YT, Dai JJ, Xu CH, Lu YK, Fan YY, Zhang XL, Zhang CX, Chen YM (2012) Greater intake of fruit and vegetables is associated with lower risk of nasopharyngeal carcinoma in Chinese adults: a case–control study. Cancer Causes Control 23:589–599. https://doi.org/10.1007/s10552-012-9923-z CrossRefPubMed

24.

Ainsworth BE, Haskell WL, Herrmann SD, Meckes N, Bassett DR Jr, Tudor-Locke C, Greer JL, Vezina J, Whitt-Glover MC, Leon AS (2011) 2011 compendium of physical activities: a second update of codes and MET values. Med Sci Sports Exerc 43:1575–1581. https://doi.org/10.1249/MSS.0b013e31821ece1225 CrossRefPubMed

25.

Zhang CX, Ho SC (2009) Validity and reproducibility of a food frequency Questionnaire among Chinese women in Guangdong province. Asia Pac J Clin Nutr 18:240–250PubMed

26.

Burri BJ, Dopler-Nelson M, Neidllinger TR (2003) Measurements of the major isoforms of vitamins A and E and carotenoids in the blood of people with spinal-cord injuries. J Chromatogr A 987:359–366. https://doi.org/10.1016/S0021-9673(02)01908-8 CrossRefPubMed

27.

Yao-Borengasser A, Varma V, Bodles AM, Rasouli N, Phanavanh B, Lee MJ, Starks T, Kern LM, Spencer HJ 3rd, Rashidi AA, McGehee RE Jr, Fried SK, Kern PA (2007) Retinol binding protein 4 expression in humans: relationship to insulin resistance, inflammation, and response to pioglitazone. J Clin Endocrinol Metab 92:2590–2597. https://doi.org/10.1210/jc.2006-0816 CrossRefPubMedPubMedCentral

28.

Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412–419CrossRef

29.

Zeng MD, Fan JG, Lu LG, Li YM, Chen CW, Wang BY, Mao YM (2008) Guidelines for the diagnosis and treatment of nonalcoholic fatty liver diseases. J Dig Dis 9:108–112. https://doi.org/10.1111/j.1751-2980.2008.00331.x CrossRefPubMed

30.

Latowski D, Kuczynska P, Strzalka K (2011) Xanthophyll cycle—a mechanism protecting plants against oxidative stress. Redox Rep 16:78–90. https://doi.org/10.1179/174329211x13020951739938 CrossRefPubMed

31.

Krinsky NI, Johnson EJ (2005) Carotenoid actions and their relation to health and disease. Aspects Med 26:459–516. https://doi.org/10.1016/j.mam.2005.10.001 CrossRef

32.

Angulo P, Lindor KD (2002) Non-alcoholic fatty liver disease. J Gastroenterol Hepatol 17(Suppl):S186–S190

33.

McCullough AJ (2002) Update on nonalcoholic fatty liver disease. J Clin Gastroenterol 34:255–262. https://doi.org/10.1097/00004836-200203000-00013 CrossRefPubMed

34.

Kaulmann A, Bohn T (2014) Carotenoids, inflammation, and oxidative stress—implications of cellular signaling pathways and relation to chronic disease prevention. Nutr Res 34:907–929. https://doi.org/10.1016/j.nutres.2014.07.010 CrossRefPubMed

35.

Akdemir B, Bahcecioglu I, Tuzcu M, Orhan C, Ispiroglu M, Ozercan I, Ilhan N, Celik N, Sahin K (2016) Effect of lycopene and genistein on hepatic inflammation and fibrosis in thioacetamide induced liver injury in rats. Br J Med Med Res 18:1–11. https://doi.org/10.9734/bjmmr/2016/27654 CrossRef

36.

Wardi J, Reifen R, Aeed H, Zadel L, Avni Y, Bruck R (2001) Beta-carotene attenuates experimentally induced liver cirrhosis in rats. Isr Med Assoc J 3:151–154PubMed

37.

Ahn J, Lee H, Jung CH, Ha T (2012) Lycopene inhibits hepatic steatosis via microRNA-21-induced downregulation of fatty acid-binding protein 7 in mice fed a high-fat diet. Mol Nutr Food Res 56:1665–1674. https://doi.org/10.1002/mnfr.201200182 CrossRefPubMed

38.

Ni Y, Zhuge F, Nagashimada M, Ota T (2016) Novel action of carotenoids on non-alcoholic fatty liver disease: macrophage polarization and liver homeostasis. Nutrients 8:391. https://doi.org/10.3390/nu8070391 CrossRefPubMedCentral

39.

Fenni S, Hammou H, Astier J, Bonnet L, Karkeni E, Couturier C, Tourniaire F, Landrier J-F (2017) Lycopene and tomato powder supplementation similarly inhibit high-fat diet induced obesity, inflammatory response, and associated metabolic disorders. Mol Nutr Food Res. https://doi.org/10.1002/mnfr.201601083 CrossRefPubMed

40.

Sugiura M, Nakamura M, Ogawa K, Ikoma Y, Yano M (2015) High serum carotenoids associated with lower risk for the metabolic syndrome and its components among Japanese subjects: Mikkabi cohort study. Br J Nutr 114:1674–1682. https://doi.org/10.1017/s0007114515003268 CrossRefPubMed

41.

Suzuki K, Ito Y, Hashimoto S, Kawado M, Inoue T, Ando M, Watanabe Y, Inaba Y, Tajima K, Nakachi K, Tamakoshi A (2009) Association of serum retinol and carotenoids with insulin-like growth factors and insulin-like growth factor binding protein-3 among control subjects of a nested case-control study in the Japan Collaborative Cohort Study. Asian Pac J Cancer Prev 10 Suppl:29–35PubMed

42.

Sugiura M, Nakamura M, Ikoma Y, Yano M, Ogawa K, Matsumoto H, Kato M, Ohshima M, Nagao A (2006) The homeostasis model assessment-insulin resistance index is inversely associated with serum carotenoids in non-diabetic subjects. J Epidemiol 16:71–78. https://doi.org/10.2188/jea.16.71 CrossRefPubMed

43.

Gunanti IR, Marks GC, Al-Mamun A, Long KZ (2014) Low serum concentrations of carotenoids and vitamin E are associated with high adiposity in Mexican–American children. J Nutr 144:489–495. https://doi.org/10.3945/jn.113.183137 CrossRefPubMed

44.

Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, Grundy SM, Hobbs HH (2004) Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 40:1387–1395. https://doi.org/10.1002/hep.20466 CrossRef

45.

Johnson EJ, Russell RM (1992) Distribution of orally administered beta-carotene among lipoproteins in healthy men. Am J Clin Nutr 56:128–135CrossRefPubMed

46.

Brown ED, Micozzi MS, Craft NE, Bieri JG, Beecher G, Edwards BK, Rose A, Taylor PR, Smith JC Jr (1989) Plasma carotenoids in normal men after a single ingestion of vegetables or purified beta-carotene. Am J Clin Nutr 49:1258–1265CrossRefPubMed

Titel: Higher serum carotenoids associated with improvement of non-alcoholic fatty liver disease in adults: a prospective study
verfasst von: Mian-li Xiao
Geng-dong Chen
Fang-fang Zeng
Rui Qiu
Wen-qi Shi
Jie-sheng Lin
Yi Cao
Hua-bin Li
Wen-hua Ling
Yu-ming Chen
Publikationsdatum: 29.03.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 2/2019
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-018-1678-1

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

25.04.2024 Allergien und Intoleranzreaktionen Nachrichten

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Trial registrations

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2019

Egg consumption and the risk of cardiovascular disease and all-cause mortality: Guangzhou Biobank Cohort Study and meta-analyses

Adipose tissue fatty acids present in dairy fat and risk of stroke: the Danish Diet, Cancer and Health cohort

Diet quality, dietary patterns and short sleep duration: a cross-sectional population-based study

Physical activity and Mediterranean diet based on olive tree phenolic compounds from two different geographical areas have protective effects on early osteoarthritis, muscle atrophy and hepatic steatosis

Adequacy of usual macronutrient intake and macronutrient distribution in children and adolescents in Spain: A National Dietary Survey on the Child and Adolescent Population, ENALIA 2013–2014