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Erschienen in:
Hintergrund/diagnostische Grundkonzepte bei Erkrankungen des vorderen Augenabschittes Kapitel lesen Erstes Kapitel lesen

2021 | OriginalPaper | Buchkapitel

21. Hintergrund/therapeutische Grundrezepte

verfasst von : Uwe Pleyer, Matthias D. Becker, Argyrios Chronopoulos, Ina Kötter, Daniel J. Salchow, Stephan Thurau, Nóra Szentmáry, Berthold Seitz, Karoline Walscheid, Christoph Tappeiner, Arnd Heiligenhaus

Erschienen in: Entzündliche Augenerkrankungen

Verlag: Springer Berlin Heidelberg

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Zusammenfassung

Die moderne Therapie der Uveitis begann in den 1950er-Jahren mit der oralen und topischen Therapie mit Kortikosteroiden (Gordon and McLean 1950). Später kamen die peri- und intraokularen Applikationsformen dazu. Mit der zunehmenden Kenntnis um die Nebenwirkungen, v. a. bei systemischer Anwendung, wurden steroidsparende Immunsuppressiva eingeführt. Hier stehen vor allem die konventionellen synthetisch hergestellten Disease Modifying Anti-Rheumatic Drugs (csDMARD) Azathioprin, Methotrexat, Ciclosporin A und die Mycophenolate im Vordergrund. Erst seit Ende der neunziger Jahre wurden auch für die Uveitistherapie zunehmend Biologika (bDMARD) wie Interferon-α, TNF (Tumor-Nekrose-Faktor)-Blocker, anti-B-Zell-Antikörper und anti-Interleukin- bzw. anti-Interleukinrezeptor-Antikörper eingesetzt.
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Metadaten
Titel
Hintergrund/therapeutische Grundrezepte
verfasst von
Uwe Pleyer
Matthias D. Becker
Argyrios Chronopoulos
Ina Kötter
Daniel J. Salchow
Stephan Thurau
Nóra Szentmáry
Berthold Seitz
Karoline Walscheid
Christoph Tappeiner
Arnd Heiligenhaus
Copyright-Jahr
2021
Verlag
Springer Berlin Heidelberg
Buch
Entzündliche Augenerkrankungen

Print ISBN: 978-3-662-60398-7

Electronic ISBN: 978-3-662-60399-4

Copyright-Jahr: 2021

DOI
https://doi.org/10.1007/978-3-662-60399-4_21

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