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Erschienen in:
22.12.2017 | Original Article
HRCT texture analysis for pure or part-solid ground-glass nodules: distinguishability of adenocarcinoma in situ or minimally invasive adenocarcinoma from invasive adenocarcinoma
Erschienen in: Japanese Journal of Radiology | Ausgabe 2/2018
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Purpose
To distinguish between adenocarcinoma in situ (AIS)–minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IAC) showing pure or part-solid ground-glass nodules (GGNs) by high-resolution computed tomography (HRCT) texture analysis.
Materials and methods
This retrospective study included 101 consecutive patients with 115 pure or part-solid GGNs ≤ 3 cm diameter, which were surgically resected and pathologically diagnosed with AIS, MIA, or IAC (48 AIS–MIA and 67 IAC) between April 2011 and March 2015. Each tumor was manually segmented on axial CT images, and the following texture features were calculated: volume, mass, mean CT value, variance, skewness, kurtosis, entropy, uniformity, and percentile CT numbers (10th, 25th, 50th, 75th, 90th, 95th percentiles). The differences between AIS–MIA and IAC were statistically evaluated using univariate, multivariate, and receiver operating characteristic analysis.
Results
Compared with IAC, AIS–MIA had significantly greater skewness, kurtosis, and uniformity, whereas in the other parameters, AIS–MIA demonstrated significantly lower values than those of IAC. Multivariate analysis revealed that independent differentiators were the 90th percentile CT numbers (P < 0.001) and entropy (P = 0.005) with an excellent accuracy (area under the curve, 0.90).
Conclusions
The 90th percentile CT numbers and entropy can accurately distinguish AIS–MIA from IAC.