Erschienen in:
01.08.2003 | Laboratory Investigations
Hyperthermia in the Treatment of Cholangiocarcinoma: Development
and Testing of an Endobiliary Microwave Device
verfasst von:
Sara Mantero, Iginio Longo, Gianfranco Beniamino Fiore, Aldo Severini
Erschienen in:
CardioVascular and Interventional Radiology
|
Ausgabe 4/2003
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Abstract
Purpose: The aim of this study was to
create, perfect and test a hyperthermia balloon catheter for local
treatment of cholangiocarcinoma. The device should induce hyperthermia
in tumor tissue by acting locally in the bile duct lumen in contact
with the tumor-infiltrated duct wall. In addition, it should exert
tissue compression to cause an appreciable reduction in tumor
microvasculature flow, thus improving thermal performance.
Methods: According to the design specifications, the working
temperature range should allow the device to be used for hyperthermia
therapy either in combination with radiation and/or chemotherapy
(radio/chemo-sensitizing effect at 42–45 °C) or alone (induction of
coagulation necrosis above 65 °C). The balloon serves as an anchoring
system during treatment and as a functional element to induce tissue
compression. In vitro mechanical evaluation of the pressure/volume
relationship, with the balloon inside rigid walled conduits, was
performed. The heating shape around the catheter tip was determined by
egg-white heating tests (coagulation at about 65 °C). Moreover,
heating tests were carried out with explanted pig liver parenchyma. The
temperature profile over time at different depths from the catheter
axis was traced.
Results: Three prototypes were
manufactured. Mechanical functional tests showed that a 14 Fr deflated
diameter balloon was suitable for bile duct diameters up to 11 mm.
Thermal egg-white tests produced 4 cm long, 3 cm in diameter
ellipsoidal heating figures in 30 min. In the biological tissue tests a
coagulated area of similar geometry and comparable volume was
produced.
Conclusion: The results of tests confirm the
device’s usefulness and versatility.