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01.04.2012 | Hepatobiliary-Pancreas

Hypervascular hepatocellular carcinomas: detection with gadoxetate disodium-enhanced MR imaging and multiphasic multidetector CT

verfasst von: Hiromitsu Onishi, Tonsok Kim, Yasuharu Imai, Masatoshi Hori, Hiroaki Nagano, Yasuhiro Nakaya, Takahiro Tsuboyama, Atsushi Nakamoto, Mitsuaki Tatsumi, Seishi Kumano, Masahiro Okada, Manabu Takamura, Kenichi Wakasa, Noriyuki Tomiyama, Takamichi Murakami

Erschienen in: European Radiology | Ausgabe 4/2012

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Abstract

Objectives

To retrospectively compare the accuracy of detection of hypervascular hepatocellular carcinoma (HCC) by multiphasic multidetector CT and by gadoxetate disodium-enhanced MR imaging.

Methods

After ethical approval, we analysed a total of 73 hypervascular HCC lesions from 31 patients suspected of having HCC, who underwent both gadoxetate disodium-enhanced MR imaging and multiphasic multidetector CT. Five blinded observers independently reviewed CT images, as well as dynamic MR images alone and combined with hepatobiliary phase MR images. Diagnostic accuracy (Az values), sensitivities and positive predictive values were compared by using the Scheffe post hoc test.

Results

The mean Az value for dynamic and hepatobiliary phase MR combined (0.81) or dynamic MR images alone (0.78) was significantly higher than that for CT images (0.67, P < 0.001, 0.005, respectively). The mean sensitivity of the combined MR images (0.67) was significantly higher than that of dynamic MR alone (0.52, P < 0.05) or CT images (0.44, P < 0.05). The mean positive predictive values were 0.96, 0.95 and 0.94, for CT, dynamic MR alone and combined MR images, respectively.

Conclusions

Compared with multiphasic multidetector CT, gadoxetate disodium-enhanced MR imaging combining dynamic and hepatobiliary phase images results in significantly improved sensitivity and diagnostic accuracy for detection of hypervascular HCC.

Key Points

• Gadoxetate disodium is a new liver-specific MR imaging contrast agent. Gadoxetate disodium-enhanced MRI helps the assessment of patients with liver disease.

• It showed high diagnostic accuracy for the detection of hepatocellular carcinoma.

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Titel: Hypervascular hepatocellular carcinomas: detection with gadoxetate disodium-enhanced MR imaging and multiphasic multidetector CT
verfasst von: Hiromitsu Onishi
Tonsok Kim
Yasuharu Imai
Masatoshi Hori
Hiroaki Nagano
Yasuhiro Nakaya
Takahiro Tsuboyama
Atsushi Nakamoto
Mitsuaki Tatsumi
Seishi Kumano
Masahiro Okada
Manabu Takamura
Kenichi Wakasa
Noriyuki Tomiyama
Takamichi Murakami
Publikationsdatum: 01.04.2012
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 4/2012
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-011-2316-y

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Springer Medizin

Hypervascular hepatocellular carcinomas: detection with gadoxetate disodium-enhanced MR imaging and multiphasic multidetector CT

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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Abstract

Objectives

Methods

Results

Conclusions

Key Points

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