Introduction
Materials and methods
Eligible genome scans
Data extraction
GSMA method
Results
Data included
Linkage evidence for each disease
2DM | Obesity | CAD | |||||||
---|---|---|---|---|---|---|---|---|---|
Pos | Bin | Cytogenetic band |
P
SR
| Bin | Cytogenetic band |
P
SR
| Bin | Cytogenetic band |
P
SR
|
1 | 6.2 | 6p22.3-p21.1 | 0.000143 | 11.2 | 11p15.1-p12 | 0.001822 | 10.5 | 10q23.33-q26.13 | 0.001135 |
2 | 9.3 | 9p21.1-q21.32 | 0.001767 | 16.3 | 16q12.2-q23.1 | 0.004428 | 9.3 | 9p21.1-q21.32 | 0.007895 |
3 | 10.5 | 10q23.33-q26.13 | 0.003829 | 19.3 | 19q12-q13.33 | 0.008426 | 16.3 | 16q12.2-q23.1 | 0.009467 |
4 | 16.3 | 16q12.2-q23.1 | 0.005043 | 6.5 | 6q23.2-q25.3 | 0.018402 | 11.5 | 11q22.3-q24.1 | 0.011467 |
5 | 3.6 | 3q22.1-q25.31 | 0.009509 | 6.4 | 6q15-q23.2 | 0.019753 | 15.3 | 15q21.3-q26.1 | 0.013732 |
6 | 8.5 | 8q22-q24.21 | 0.026031 | 4.5 | 4q24-q28.3 | 0.025605 | 7.3 | 7p14.1-q21.11 | 0.026741 |
7 | 11.2 | 11p15.1-p12 | 0.034162 | 9.3 | 9p21.1-q21.32 | 0.036314 | 9.4 | 9q21.32-q31.1 | 0.032157 |
8 | 6.4 | 6q15-q23.2 | 0.035033 | 9.4 | 9q21.32-q31.1 | 0.042022 | 7.4 | 7q12.11-q31.1 | 0.046022 |
Linkage evidence for combined each two or all three diseases
2DM/CAD | 2DM/Obesity | |||||
---|---|---|---|---|---|---|
Pos | Bin | Cytogenetic band |
P
SR
| Bin | Cytogenetic band |
P
SR
|
1 | 9.3 | 9p21.1-q21.32 | 0.002362 | 16.3 | 16q12.2-q23.1 | 4.75E-05 |
2 | 6.2 | 6p22.3-p21.1 | 0.005861 | 4.5 | 4q24-q28.3 | 0.000159 |
3 | 7.4 | 7q12.11-q31.1 | 0.022381 | 9.3 | 9p21.1-q21.32 | 0.000543 |
4 | 16.3 | 16q12.2-q23.1 | 0.022471 | 6.5 | 6q23.2-q25.3 | 0.003457 |
5 | 4.1 | 4pter-p15.33 | 0.024538 | 2.3 | 2p23.2-p16.2 | 0.00572 |
6 | 22.2 | 22q12.3-pter | 0.030478 | 4.4 | 4q13.3-q24 | 0.010083 |
7 | 17.2 | 17p12-q21.33 | 0.045176 | 12.3 | 12p11.21-q15 | 0.029702 |
CAD/Obesity
|
All three diseases
| |||||
Pos
|
Bin
|
Cytogenetic band
|
P
SR
|
Bin
|
Cytogenetic band
|
P
SR
|
1 | 16.3 | 16q12.2-q23.1 | 0.006016 | 9.3 | 9p21.1-q21.32 | 0.000276 |
2 | 6.5 | 6q23.2-q25.3 | 0.006592 | 16.3 | 16q12.2-q23.1 | 0.000505 |
3 | 16.2 | 16p13-q12.2 | 0.030775 | 6.5 | 6q23.2-q25.3 | 0.002055 |
4 | 9.3 | 9p21.1-q21.32 | 0.040512 | 4.5 | 4q24-q28.3 | 0.004021 |
5 | 10.5 | 10q23.33-q26.13 | 0.041678 | 7.3 | 7p14.1-q21.11 | 0.011893 |
6 | 11.2 | 11p15.1-p12 | 0.041838 | 3.6 | 3q22.1-q25.31 | 0.014341 |
7 | 4.5 | 4q24-q28.3 | 0.042347 | 4.4 | 4q13.3-q24 | 0.019338 |
8 | 7.3 | 7p14.1-q21.11 | 0.043952 | 11.3 | 11p12-q13.3 | 0.022461 |