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01.09.2010 | Computed Tomography

Identifying the most infectious lesions in pulmonary tuberculosis by high-resolution multi-detector computed tomography

verfasst von: Jun Jun Yeh, Solomon Chih-Cheng Chen, Wen-Bao Teng, Chun-Hsiung Chou, Shih-Peng Hsieh, Tsung-Lung Lee, Ming-Ting Wu

Erschienen in: European Radiology | Ausgabe 9/2010

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Abstract

Objective:

This study aimed to determine whether characteristics detected by multi-detector computed tomography (MDCT) were predictive of highly infectious, smear-positive, active pulmonary tuberculosis (PTB).

Methods:

Among 124 patients with active PTB, 84 had positive (group 1) and 40 had negative (group 2) smear results for acid-fast bacilli. Multiplanar MDCT, axial conventional CT and chest X-ray images were analysed retrospectively for morphology, number, and segmental (lobe) distribution of lesions.

Results:

By multivariate analysis, consolidation over any segment of the upper, middle, or lingual lobes, cavitations, and clusters of nodules were associated with group 1, while centrilobular nodules were predictive of group 2. Using five independent variables associated with risk in group 1, a prediction model was created to distinguish between group 1 and group 2. ROC curve analysis showed an area under the curve of 0.951 ± 0.021 for this prediction model. With the ideal cutoff point score of 1, the sensitivity, specificity, and positive predictive values were 84.5%, 97.5%, and 98.0%, respectively.

Conclusions:

A model to predict smear-positive active PTB on the basis of findings from MDCT may be a useful tool for clinical decisions about isolating patients pending sputum smear results.

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Titel: Identifying the most infectious lesions in pulmonary tuberculosis by high-resolution multi-detector computed tomography
verfasst von: Jun Jun Yeh
Solomon Chih-Cheng Chen
Wen-Bao Teng
Chun-Hsiung Chou
Shih-Peng Hsieh
Tsung-Lung Lee
Ming-Ting Wu
Publikationsdatum: 01.09.2010
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 9/2010
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-010-1796-5

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Identifying the most infectious lesions in pulmonary tuberculosis by high-resolution multi-detector computed tomography