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Immunologic Research
Erschienen in: Immunologic Research 2-3/2011

01.08.2011 | UNIVERSITY OF PITTSBURGH IMMUNOLOGY 2011

IL-17 signaling in host defense against Candida albicans

verfasst von: Sarah L. Gaffen, Nydiaris Hernández-Santos, Alanna C. Peterson

Erschienen in: Immunologic Research | Ausgabe 2-3/2011

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Abstract

The discovery of the Th17 lineage in 2005 triggered a major change in how immunity to infectious diseases is viewed. Fungal infections, in particular, have long been a relatively understudied area of investigation in terms of the host immune response. Candida albicans is a commensal yeast that colonizes mucosal sites and skin. In healthy individuals, it is non-pathogenic, but in conditions of immune deficiency, this organism can cause a variety of infections associated with considerable morbidity. Candida can also cause disseminated infections that have a high mortality rate and are a major clinical problem in hospital settings. Although immunity to Candida albicans was long considered to be mediated by Th1 cells, new data in both rodent models and in humans have revealed an essential role for the Th17 lineage, and in particular its signature cytokine IL-17.
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Metadaten
Titel
IL-17 signaling in host defense against Candida albicans
verfasst von
Sarah L. Gaffen
Nydiaris Hernández-Santos
Alanna C. Peterson
Publikationsdatum
01.08.2011
Verlag
Humana Press Inc
Erschienen in
Immunologic Research / Ausgabe 2-3/2011
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-011-8226-x

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