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European Journal of Clinical Microbiology & Infectious Diseases

Erschienen in:

01.02.2004 | Article

Immunocompetent Hosts as a Reservoir of Pneumocystis Organisms: Histological and RT-PCR Data Demonstrate Active Replication

verfasst von: M. Chabé, E. Dei-Cas, C. Creusy, L. Fleurisse, N. Respaldiza, D. Camus, I. Durand-Joly

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 2/2004

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Abstract

The present study was conducted to further examine recent data suggesting that pneumocystosis could be transmitted between patients and healthcare workers in the hospital environment, as has been proven with Pneumocystis-infected SCID mice and immunocompetent Balb/c mice. Using an experimental design (i.e., SCID–Balb/c mouse airborne transmission system), the present work found that healthy host-to-healthy host transmission of Pneumocystis organisms can occur, and that ‘second’ healthy contacts are able to transmit the infectious organisms to immunocompromised hosts. Further tests designed to explore the behavior of Pneumocystis organisms in the lungs of immunocompetent hosts were performed using histological and molecular approaches (e.g. testing the expression of both cyclin-dependent serine-threonine kinase and heat-shock 70 protein in Pneumocystis). The results showed Pneumocystis organisms were able to replicate in the lungs of immunocompetent hosts, which indicates these hosts are a reservoir for Pneumocystis spp.

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Titel: Immunocompetent Hosts as a Reservoir of Pneumocystis Organisms: Histological and RT-PCR Data Demonstrate Active Replication
verfasst von: M. Chabé
E. Dei-Cas
C. Creusy
L. Fleurisse
N. Respaldiza
D. Camus
I. Durand-Joly
Publikationsdatum: 01.02.2004
Verlag: Springer-Verlag
Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 2/2004
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-003-1092-2

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