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International Journal of Clinical Oncology

Erschienen in:

01.04.2013 | Original Article

Impact of chemotherapy-related prognostic factors on long-term survival in patients with stage III colorectal cancer after curative resection

verfasst von: Wen-Sy Tsai, Pao-Shiu Hsieh, Chien-Yuh Yeh, Jy-Ming Chiang, Reiping Tang, Jinn-Shiun Chen, Chung Rong Changchien, Jeng Yi Wang

Erschienen in: International Journal of Clinical Oncology | Ausgabe 2/2013

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Abstract

Background

This retrospective study evaluated the prognostic factors of chemotherapy in stage III colorectal cancer after curative resection.

Methods

From 1996 to 2001, 1,054 patients with primary single colorectal cancer underwent curative resection. Seven hundred sixteen patients received various 5-fluorouracil (FU)-based adjuvant chemotherapy regimens, including oral and intravenous treatments. The chemotherapy-related parameters examined included therapeutic duration, frequency, route of administration, composition of combination therapies, and postoperative time interval from the operation to the start of chemotherapy.

Results

The therapeutic duration and postoperative time interval of starting therapy were independent prognostic factors, in addition to clinicopathological factors. The 8-year cancer-specific/overall survival rates in patients who received chemotherapy for >4 months (63.0/58.6%) were significantly higher than the rates in patients who received no chemotherapy (56.7/37.7%, P < 0.01) and those who remained on chemotherapy for 1–4 months (49.4/41.9%, P < 0.05). The 8-year cancer-specific/overall survival rates in patients who waited 1–5 weeks after surgery to receive chemotherapy (62.9/58.5%) were significantly higher versus rates in those who did not receive chemotherapy (56.7/37.7%) and those who did not receive chemotherapy until >5 weeks after surgery (52.3/45.9%) (both P < 0.05). Survival rates did not differ between patients who did not undergo chemotherapy, those for whom chemotherapy lasted 1–4 months, and patients who did not receive chemotherapy until >5 weeks after surgery.

Conclusions

The appropriate duration of therapy and early chemotherapy after surgery were 2 of the most important factors in eradicating occult cancer and effecting long-term survival benefits in patients with stage III colorectal cancer.

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Titel: Impact of chemotherapy-related prognostic factors on long-term survival in patients with stage III colorectal cancer after curative resection
verfasst von: Wen-Sy Tsai
Pao-Shiu Hsieh
Chien-Yuh Yeh
Jy-Ming Chiang
Reiping Tang
Jinn-Shiun Chen
Chung Rong Changchien
Jeng Yi Wang
Publikationsdatum: 01.04.2013
Verlag: Springer Japan
Erschienen in: International Journal of Clinical Oncology / Ausgabe 2/2013
Print ISSN: 1341-9625
Elektronische ISSN: 1437-7772
DOI: https://doi.org/10.1007/s10147-011-0370-8

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Impact of chemotherapy-related prognostic factors on long-term survival in patients with stage III colorectal cancer after curative resection