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Metabolic Brain Disease

Erschienen in:

29.06.2018 | Original Article

Improving cognitive task in kindled rats by using low frequency stimulation during epileptogenesis

verfasst von: Zohreh Ghotbeddin, Ahmad Ali Moazedi, Ali Yadollahpour, Faezeh Rendi, Mostafa Jalilifar

Erschienen in: Metabolic Brain Disease | Ausgabe 5/2018

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Abstract

Numerous studies indicate that one of the bad effects of epilepsy is cognitive impairment. In this study we focused on the effect of LFS as a potential anticonvulsant agent, during epileptogenesis on cognitive impairments induced by amygdala kindling in rat. Twenty-one adult rats were divided into 3 groups including control (n = 7), kindled (n = 7), and Kindled+LFS (KLFS) (n = 7). Animals in the kindled group received kindling stimulation in a rapid kindling manner (a 3 s train of 50 Hz monophasic pulses of 1 ms duration, 12 times a day) in amygdala whereas control animals had no stimulation. Four packages of LFS (each package consisting of 200 monophasic square pulses, 0.1 ms pulse duration at 1 Hz) were applied daily after termination of kindling stimulation in KLFS group. Spatial memory of all animals was tested using radial arm maze after termination of stimulation on acquisition trial days and 14 days after the final acquisition trial test. Epileptogenesis process significantly increased working and reference memory error compared to control groups whereas application of LFS immediately after kindling stimulation prevented this impairment in 8 arm radial maze and there was no significant difference between KLS and control groups. Our results indicated that application of LFS during kindling acquisition suppresses memory impairment in epileptogenesis by kindling stimulation.

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Titel: Improving cognitive task in kindled rats by using low frequency stimulation during epileptogenesis
verfasst von: Zohreh Ghotbeddin
Ahmad Ali Moazedi
Ali Yadollahpour
Faezeh Rendi
Mostafa Jalilifar
Publikationsdatum: 29.06.2018
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 5/2018
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-018-0260-0

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