Erschienen in:
01.08.2003 | Laboratory Investigations
In Vivo Evaluation of the Effects of Gravitational Force (+Gz) on
Over-the-Wire Stainless Steel Greenfield Inferior Vena
Cava Filter in Swine
verfasst von:
P.M. Sherman, G.M. Soares, E.J. Dick, H.H. Harroff, P.M. Werchan, M.R. Davis, D.P. Ortegon
Erschienen in:
CardioVascular and Interventional Radiology
|
Ausgabe 4/2003
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Abstract
This study was done to determine the effect of
exposure to gravitational force (acceleration stress) on in
vivo over-the-wire stainless steel Greenfield inferior vena cava
filters. Fifteen pigs underwent venous cut down and placement of a
stainless steel Greenfield filter. A 4-week observation period
simulated realistic convalescence and allowed sufficient time for
epithelialization. Ten pigs were exposed to acceleration stress in a
centrifuge (3G run for 15 sec followed by rest until return to baseline
heart rate, then a 9G run for 15 sec), with inertial loading in a
head-to-tail direction (+Gz). Fluoroscopy during acceleration stress
allowed assessment for filter migration. Five pigs were not exposed to
acceleration stress. AP and lateral abdominal radiographs were obtained
at post-filter placement, convalescence, and centrifuge exposure to
determine the position and integrity of the filter. All 15 IVCs were
resected and evaluated for gross or histological injury to the vessel
wall. IVC filter placement was technically successful in all 15 pigs.
Radiographic measurements were limited secondary to differences in pig
positioning. Fluoroscopy showed no filter migration. All filters were
securely attached to the vena cava by the hooks without gross evidence
of perforation or hemorrhage. There were varying degrees of fibroplasia
involving the hooks and tip of the filters in both the control and
experimental groups. Histologically, there was evidence of prior
hemorrhage at the level of the hooks, which was similar between the
control and experimental groups. It is concluded that Greenfield filter
position and vena caval integrity at the implantation site is
unaffected by high acceleration stress.