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The Cerebellum

Erschienen in:

01.06.2010

In Vivo Structural and Functional Imaging of the Human Rubral and Inferior Olivary Nuclei: A Mini-review

verfasst von: Christophe Habas, Rémy Guillevin, Abdelouhab Abanou

Erschienen in: The Cerebellum | Ausgabe 2/2010

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Abstract

Few imaging studies have been devoted to the structural and functional connectivity of the red and inferior olivary nuclei although these two nuclei represent two main targets of the cerebellum within the brainstem. However, the RN is anatomically and functionally related to a widespread sensorimotor, limbic, and executive brain network. It projects massively onto the principal olive with which it contributes to a cerebello-rubro-olivo-cerebellar loop modulated by cortical and subcortical afferents. Despite a minor role in planning and execution of rhythmic movements, the red nucleus in conjunction with the inferior olive, more specifically involved in the detection of “unexpected” events, contributes to sensorimotor, sensory and, likely, cognitive higher functions.

Massion J (1967) The mammalian red nucleus. Physiol Rev 47:383–436PubMed

Azizi SA (2007) ...And the olive said to the cerebellum: organization and functional significance of the olivo-cerebellar system. Neuroscientist 13:646–625

Nieuwenhuys R, Voogt J, vanHuijzen C (eds) (2008) The human central nervous system. A synopsis and atlas, 4th revised edn. Springer, Berlin Heidelberg New York

ten Donkelaar HJ (1988) Evolution of the red nucleus and the rubrospinal tract. Behav Brain Res 28:9–20CrossRefPubMed

Lapresle J (1979) Rhythmic palatal myoclonus and the dentate-olivary pathway. J Neurol 200:223–230CrossRef

Larochelle L, Bedard P, Boucher R, Poirier LJ (1970) The rubro-olivo-cerebello-rubral loop and postural tremor in the monkey. J Neurol Sci 11:53–64CrossRefPubMed

Lavezzi AM, Corna M, Matturri L, Santoro F (2009) Neuropathology of the Guillain–Mollaret Triangle (dentate-rubro-olivary network) in sudden unexplained perinatal death and SIDS. Open Neurol J 3:48–53CrossRefPubMed

Miller LE, van Kan PL, Sinjjaer T, Andersen T, Harris GD, Houk JC (1993) Correlation of primate red nucleus discharge with muscle activity during free-form arm movements. J Physiol 469:213–243PubMed

Lefebvre V, Josien E, Pasquier F, Steinling M, Petit H (1993) Infarctus du noyau rouge et diaschisis cérébelleux croisé. Rev Neurol (Paris) 149:294–296

10.

Ito M (2005) Bases and implications of learning in the cerebellum—adaptative control and internal model mechanism. Prog Brain Res 148:95–109CrossRefPubMed

11.

Llinas RR (2009) Inferior olive oscillation as the temporal basis for motricity and oscillatory reset as the basis for motor error correction. Neuroscience 162:797–804CrossRefPubMed

12.

Thompson RF, Steinmetz JE (2009) The role of cerebellum in classical conditioning of discrete behavioural responses. Neurosci 162:732–755CrossRef

13.

Jacobson GA, Rokni D, Yarom Y (2008) A model of the olivo-cerebellar system as a temporal pattern generator. Trends Neurosci 31:617–625CrossRefPubMed

14.

Schmahmann JD, Pandya DN (1997) The cerebrocerebellar system. Int Rev Neurobiol 41:31–60CrossRefPubMed

15.

Kelly RM, Strick PL (2003) Cerebellar loops with motor cortex and prefrontal cortex of a nonhuman primate. J Neurosci 23:8432–8444PubMed

16.

Ralston DD (1994) Corticorubral synaptic organization in Macaca fascicularis: a study utilizing degeneration, anterograde transport of WGA-HRP, and combined immuno-GABA-gold technique and computer-assisted reconstruction. J Comp Neurol 50:657–673CrossRef

17.

Humphrey DR, Gold R, Reed DJ (1984) Sizes, laminar and topographical origins of cortical projections to the major divisions of the red nucleus in the monkey. J Comp Neurol 225:75–94CrossRefPubMed

18.

Stanton GB (1980) Topographical organization of ascending cerebellar projections from the dentate and interposed nuclei in Macaca mulatta: an anterograde degeneration study. J Comp Neurol 190:699–731CrossRefPubMed

19.

Miller RA, Strominger NL (1973) Efferent connections of the red nucleus in the brainstem and spinal cord of the rhesus monkey. J Comp Neurol 152:327–346CrossRefPubMed

20.

Ito M (1984) The cerebellum and neural control. Raven, New York

21.

Von Monakow C (1895) Experimentelle und pathologisch-anatomische Untersuchungen über die Haubenregion, den Schlügel und die Regio subthalamica nebst Beiträge zur Kenntnis früh erworbener Gross- und Kleinhirndefecte. Arch Psychiatr Nervenkr 27:1–128 386-478CrossRef

22.

Archambault L (1914-1915) Les connexions corticales du noyau rouge. Nouvelle Iconographie Salpêtrière 27:188–225

23.

Meyer M (1949) Study of efferent connections of the frontal lobe in the human brain after leucotomy. Brain 72:265–296CrossRefPubMed

24.

Kanki S, Ban T (1952) Corticofugal connections of the frontal lobe in man. Med J Osaka Univ 3:201–222

25.

Habas C, Cabanis EA (2006) Cortical projections to the human red nucleus: a diffusion tensor tractography study with a 1.5-T machine. Neuroradiology 48:755–762CrossRefPubMed

26.

Habas C, Cabanis EA (2007) Cortical projections to the human red nucleus: complementary results with probabilistic tractography at 3 T. Neuroradiology 49:777–784CrossRefPubMed

27.

Habas C, Cabanis EA (2007) Anatomical parcellation of the brainstem and cerebellar white matter: a preliminary probabilistic tractography study at 3 T. Neuroradiology 49:849–863CrossRefPubMed

28.

Granziera C, Schmahmann JD, Hadjikhani N, Meyer H, Meuli R, Wedeen V, Krueger G (2009) Diffusion spectrum imaging shows the structural basis of functional cerebellar circuits in the human cerebellum system in vivo. PLOSone 4

29.

Biswal B, Yetkin FZ, Haughton VM, Hyde JS (1995) Functional connectivity in the motor cortex of resting brain using echo-planar MRI. Magn Reson Med 34:537–541CrossRefPubMed

30.

Fox MD, Raischle ME (2007) Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci 8:700–711CrossRefPubMed

31.

Nioche C, Cabanis EA, Habas C (2009) Functional connectivity of the human red nucleus in the brain resting state at 3 T. AJNR Am J Neuroradiol 30:396–403CrossRefPubMed

32.

Habas C, Kamdar N, Nguyen D, Prater K, Beckmann CF, Menon V, Greicius MD (2009) Distinct cerebellar contributions to intrinsic connectivity networks. J Neurosci 29:8586–8594CrossRefPubMed

33.

Liu Y, Pu Y, Gao JH, Parsons LM, Xiong J, Liotti M, Bower JM, Fox PT (2000) The human red nucleus and lateral cerebellum in supporting roles for sensory information processing. Hum Brain Mapp 10:147–159CrossRefPubMed

34.

Habas C, Cabanis EA (2007) The neural network involved in a bimanual tactile-tactile matching discrimination task: a functional imaging study at 3 T. Neuroradiology 49:681–688CrossRefPubMed

35.

Xu D, Liu T, Ashe J, Bushara KO (2006) Role of the olivo-cerebellar system in timing. J Neurosci 26:5990–5995CrossRefPubMed

36.

Cunnington R, Windischberger C, Deecke L, Moser E (2002) The preparation and execution of self-initiated and externally-triggered movement: a study of event-related fMRI. NeuroImage 15:373–385CrossRefPubMed

37.

Boecker H, Jankowski J, Ditter P, Scheef L (2008) A role of the basal ganglia and midbrain nuclei for initiation of motor sequences. NeuroImage 39:1356–1369CrossRefPubMed

38.

Wetter TC, Eisensehr I, Trenkwalder C (2004) Functional neuroimaging studies in restless legs syndrome. Sleep Med 5:401–406CrossRefPubMed

39.

Boecker H, Kleinschmidt A, Weindl A, Conrad B, Hänicke W, Frahm J (1994) Dysfunctional activation of subcortical nuclei in palatal myoclonus detected by high-resolution MRI. NMR Biomedecin 7:327–329CrossRef

40.

Bingel U, Quante M, Knab R, Bromm B, Weiller C, Büchel C (2003) Single fMRI reveals significant contralateral bias in responses to laser pain within thalamus and somatosensory cortices. NeuroImage 18:740–748CrossRefPubMed

41.

Dunckley P, Wise RG, Fairhurst M, Hobden P, Aziz Q, Chang L, Tracey I (2005) A comparison of visceral and somatic pain processing in the human brainstem using functional magnetic resonance imaging. J Neurosci 25:7333–7341CrossRefPubMed

42.

Bhatt S, Mbwana J, Adeymo A, Sawyer A, Hailu A, VanMeter J (2009) Lying about facial recognition: an fMRI study. Brain Cogn 69:382–390CrossRefPubMed

43.

Sörös P, Sokoloff LG, Bose A, McIntosh AR, Graham SJ, Stuss DT (2006) Clustered functional of overt speech production. NeuroImage 32:376–387CrossRefPubMed

44.

Alain C, Reinke K, McDonald KL, Chau W, Tam F, Pacucar A, Graham S (2005) Left thalamo-cortical network implicated in successful speech separation and identification. NeuroImage 26:592–599CrossRefPubMed

45.

Desmond JE, Gabrieli JDE, Wagner AD, Ginier BL, Glover GH (1997) Lobular patterns of cerebellar activation in verbal working-memory and finger-tapping tasks as revealed by functional MRI. J Neurosci 17:9675–9685PubMed

46.

Pu Y, Liu Y, JH GAO, Parsons LM, Xiong J, Liotti M, Qin YL, Bower JM, Fox PT (1998) Implication of human inferior olive in sensory discrimination, a fMR study (Abstract). Society of Neurosci 24:1150

47.

Liu T, Xu D, Ashe J, Bushara K (2008) The specificity of inferior olive response to stimulus timing. J Neurophysiol 100:1557–1561CrossRefPubMed

48.

Gautier JC, Blackwood W (1961) Enlargement of the inferior olivary nucleus in association with lesions of the central tegmental tract or dentate nucleus. Brain 84:341CrossRefPubMed

49.

Jellinger K (1973) Hypertrophy of the inferior olives: report on 29 cases. Z Neurol 205:153CrossRefPubMed

50.

Gotto N, Kakimi S, Kaneko M (1988) Olivary enlargement: stage of initial astrocytic changes. Clin Neuropathol 7:39–43

51.

Goyal M, Versnick E, Tuite P, Saint Cyr J, Kucharczyk W, Montanera W, Willinsky R, Mikulis D (2000) Hypertrophic olivary degeneration: metaanalysis of the temporal evolution of MR findings. AJNR Am J Neuroradiol 21:1073–1077PubMed

52.

Guillain G, Mollaret P (1931) Deux cas de myoclonies synchrones et rythmées vélo-pharyngo-laryngo-oculo-diaphragmatiques. Rev Neurol (Paris) 2:545

53.

Duvelleroy Hommet C, de Toffol B, Cottier JP, Autret A (1998) Bilateral olivary hypertrophy and palatal myoclonus. Surg Neurol 49:215–216CrossRef

54.

Wu JC, Lu CS, Ng SH (2000) Limb myorhythmia in association with hypertrophy of the inferior olive: report of two cases. Chang Gung Med J 23:630–635PubMed

55.

56.

Nitschke MF, Kruger G, Bruhn H, Klein C, Gehrking E, Wessel K, Frahm J, Vieregge P (2001) Voluntary palatal tremor is associated with hyperactivation of the inferior olive: a functional magnetic resonance imaging study. Mov Disord 16:1193–1195CrossRefPubMed

57.

Hong S, Leigh RJ, Zee DS, Optican LM (2008) Inferior olive hypertrophy and cerebellar learning are both needed to explain ocular oscillations in oculopalatal tremor. Prog Brain Res 171:219–226CrossRefPubMed

58.

Ramnani N, Behrens TEJ, Johansen-Berg H, Richter MC, Pinsk MA, Andersson JLR, Rudebeck P, Ciccarelli et al (2005) The evolution of prefrontal inputs to the cortico-pontine system: diffusion imaging evidence from macaque monkeys and humans. Cereb Cortex 16:811–818CrossRefPubMed

59.

Habas C (2009) Functional imaging of the deep cerebellar nuclei: a review. Cerebellum Jun 10 [Epub ahead of print]

60.

Stoodley CJ, Schmahmann JD (2008) Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies. NeuroImage 44:489–501CrossRefPubMed

61.

Schmahmann (2004) Disorders of the cerebellum: ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome. J Neuropsych Clin Neurosci 16:367–378

62.

Barton RA, Harvey PH (2000) Mosaic evolution of brain structure in mammals. Nature 405:1055–1058CrossRefPubMed

Titel: In Vivo Structural and Functional Imaging of the Human Rubral and Inferior Olivary Nuclei: A Mini-review
verfasst von: Christophe Habas
Rémy Guillevin
Abdelouhab Abanou
Publikationsdatum: 01.06.2010
Verlag: Springer-Verlag
Erschienen in: The Cerebellum / Ausgabe 2/2010
Print ISSN: 1473-4222
Elektronische ISSN: 1473-4230
DOI: https://doi.org/10.1007/s12311-009-0145-1

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