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Erschienen in: Surgical Endoscopy 8/2019

17.04.2019 | Review Article

Incidence and predictors of postoperative ileus after loop ileostomy closure: a systematic review and meta-analysis

verfasst von: Richard Garfinkle, Paul Savage, Marylise Boutros, Tara Landry, Pauline Reynier, Nancy Morin, Carol-Ann Vasilevsky, Kristian B. Filion

Erschienen in: Surgical Endoscopy | Ausgabe 8/2019

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Abstract

Introduction

Postoperative ileus (POI) is regarded as the most clinically significant morbidity following loop ileostomy closure; however, its incidence remains poorly understood. Our objective was therefore to determine the pooled incidence of POI after loop ileostomy closure and identify risk factors associated with its development.

Methods

We systematically searched MEDLINE (via Ovid and PubMed), Embase, the Cochrane Library, Biosis Previews, and Scopus to identify studies reporting the incidence of POI in patients who underwent loop ileostomy closure. Two independent reviewers extracted data and appraised study quality. Cumulative incidence proportions were pooled across studies using a random-effects meta-analytic model.

Results

Sixty-seven studies, including 9528 patients, met our inclusion criteria. The pooled estimate of POI was 8.0% (95% CI 6.9–9.3%; I2 = 74%). The estimated incidence varied by POI definition: studies with a robust definition of POI (n = 8) demonstrated the highest estimate of POI (12.4%, 95% CI 9.2–16.5%; I2 = 79%) while studies that did not report an explicit POI definition (n = 38) demonstrated the lowest estimate (6.7%, 95% CI 5.3–8.3%; I2 = 61%). Small bowel anastomosis technique (hand-sewn) and interval time from ileostomy creation to closure (longer time) were the factors most commonly associated with POI after loop ileostomy closure. However, most comparative studies were not powered to examine risk factors for POI.

Conclusions

POI is an important complication after loop ileostomy closure, and its incidence is dependent on its definition. More research aimed at studying this complication is required to better understand risk factors for POI after loop ileostomy closure.
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Metadaten
Titel
Incidence and predictors of postoperative ileus after loop ileostomy closure: a systematic review and meta-analysis
verfasst von
Richard Garfinkle
Paul Savage
Marylise Boutros
Tara Landry
Pauline Reynier
Nancy Morin
Carol-Ann Vasilevsky
Kristian B. Filion
Publikationsdatum
17.04.2019
Verlag
Springer US
Erschienen in
Surgical Endoscopy / Ausgabe 8/2019
Print ISSN: 0930-2794
Elektronische ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-019-06794-y

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