01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Incidence of solitary pulmonary nodules in Northeastern France: a population-based study in five regions
- Zeitschrift:
- BMC Cancer > Ausgabe 1/2017
Background
Methods
Study design and setting
Participants
SPN report inclusion and data collection
Statistical analysis
Results
Participants
Description of patients
2002–2003
|
2004–2005
|
|||
---|---|---|---|---|
n = 154
|
n = 297
|
|||
n
|
%
|
n
|
%
|
|
Patients
|
||||
Age
|
||||
≥ 50 years
|
127
|
82.5
|
245
|
82.5
|
Gender
|
||||
Men
|
112
|
72.7
|
193
|
65.0
|
Women
|
42
|
27.3
|
104
|
35.0
|
Region
|
||||
Alsace
|
32
|
20.8
|
79
|
26.6
|
Bourgogne
|
18
|
11.7
|
36
|
12.1
|
Champagne-Ardenne
|
32
|
20.8
|
43
|
14.5
|
Franche-Comté
|
24
|
15.6
|
27
|
9.1
|
Lorraine
|
48
|
31.1
|
112
|
37.7
|
Smoking
|
||||
Current or ex-smokers
|
96
|
82.1
|
154
|
64.7
|
Non smokers
|
21
|
17.9
|
84
|
35.3
|
No information
|
37
|
59
|
||
Referring physician for CT
|
||||
General practitioner
|
41
|
29.1
|
89
|
30.0
|
Specialist
|
100
|
70.9
|
208
|
70.0
|
No information
|
13
|
0
|
||
Solitary pulmonary nodule
|
||||
Spiculation
|
||||
Yes
|
49
|
81.7
|
55
|
37.9
|
No
|
11
|
18.3
|
90
|
62.1
|
No information
|
94
|
152
|
||
Calcification
|
||||
Yes
|
13
|
33.3
|
54
|
36.5
|
No
|
26
|
66.7
|
94
|
63.5
|
No information
|
115
|
149
|
||
Discovered by
|
||||
Chest radiography
|
79
|
53.4
|
101
|
35.2
|
Chest CT
|
69
|
46.6
|
186
|
64.8
|
No information
|
6
|
10
|
||
Follow-up at 6 months
|
||||
Cancer
|
||||
Yes
|
33
|
26.4
|
53
|
22.1
|
No
|
92
|
73.6
|
187
|
77.9
|
No information
|
29
|
57
|
||
Death
|
||||
Yes
|
24
|
15.6
|
26
|
8.8
|
No
|
130
|
84.4
|
271
|
91.2
|
Incidence rates
Men
|
Women
|
||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
2002–2003
|
2004–2005
|
2002–2003
|
2004–2005
|
||||||||||||||
Person-years
|
416,926
|
683,299
|
437,200
|
716,751
|
|||||||||||||
IR
a
|
95% CI
b
|
IR
a
|
95% CI
b
|
IR
a
|
95% CI
b
|
IR
a
|
95% CI
b
|
||||||||||
IR
a by age group (years)
|
20–25
|
0.0
|
0.0
|
–
|
10.8
|
0.0
|
0.0
|
–
|
6.5
|
0.0
|
0.0
|
–
|
11.1
|
2.3
|
0.1
|
–
|
12.6
|
25–30
|
0.0
|
0.0
|
–
|
11.2
|
9.6
|
2.6
|
–
|
24.6
|
0.0
|
0.0
|
–
|
11.4
|
9.8
|
2.7
|
–
|
25.2
|
|
30–35
|
6.6
|
0.8
|
–
|
23.7
|
6.2
|
1.3
|
–
|
18.2
|
0.0
|
0.0
|
–
|
10.0
|
2.1
|
0.1
|
–
|
11.7
|
|
35–40
|
12.8
|
3.5
|
–
|
32.8
|
8.0
|
2.2
|
–
|
20.6
|
0.0
|
0.0
|
–
|
9.7
|
2.0
|
0.1
|
–
|
11.3
|
|
40–45
|
13.0
|
3.5
|
–
|
33.3
|
5.9
|
1.2
|
–
|
17.4
|
19.2
|
7.1
|
–
|
41.9
|
7.9
|
2.1
|
–
|
20.1
|
|
45–50
|
22.9
|
9.2
|
–
|
47.2
|
26.3
|
14.0
|
–
|
45.0
|
3.2
|
0.1
|
–
|
18.0
|
15.8
|
6.8
|
–
|
31.2
|
|
50–55
|
45.3
|
24.7
|
–
|
75.9
|
30.3
|
17.0
|
–
|
50.0
|
9.8
|
2.0
|
–
|
28.7
|
24.1
|
12.5
|
–
|
42.1
|
|
55–60
|
33.7
|
14.5
|
–
|
66.3
|
48.6
|
30.4
|
–
|
73.5
|
8.5
|
1.0
|
–
|
30.8
|
22.3
|
10.7
|
–
|
41.0
|
|
60–65
|
53.6
|
25.7
|
–
|
98.5
|
86.0
|
56.1
|
–
|
125.9
|
15.4
|
3.2
|
–
|
45.1
|
35.3
|
17.6
|
–
|
63.2
|
|
65–70
|
67.3
|
34.8
|
–
|
117.6
|
90.0
|
58.8
|
–
|
131.9
|
14.6
|
3.0
|
–
|
42.6
|
18.2
|
6.7
|
–
|
39.6
|
|
70–75
|
136.7
|
85.7
|
–
|
207.0
|
114.1
|
77.0
|
–
|
162.9
|
52.6
|
26.3
|
–
|
94.2
|
23.6
|
10.2
|
–
|
46.6
|
|
>75
|
127.1
|
85.1
|
–
|
182.5
|
118.3
|
86.9
|
–
|
157.3
|
31.0
|
16.5
|
–
|
53.0
|
53.0
|
37.5
|
–
|
72.8
|
|
Crude rate
|
26.9
|
22.1
|
–
|
32.3
|
28.2
|
24.4
|
–
|
32.5
|
9.6
|
6.9
|
–
|
13.0
|
14.5
|
11.9
|
–
|
17.6
|
|
Standardised IR
c
|
16.4
|
13.2
|
–
|
19.6
|
17.7
|
15.0
|
–
|
20.4
|
4.9
|
3.2
|
–
|
6.6
|
8.2
|
6.4
|
–
|
10.0
|
Alsace
|
Bourgogne
|
Champagne-Ardenne
|
Franche-Comté
|
Lorraine
|
|||||||
---|---|---|---|---|---|---|---|---|---|---|---|
IR
a
|
95% CI
b
|
IR
a
|
95% CI
b
|
IR
a
|
95% CI
b
|
IR
a
|
95% CI
b
|
IR
a
|
95% CI
b
|
||
Men
|
|||||||||||
2002–2003
|
Crude rate
|
22.0
|
13.8–33.3
|
12.2
|
6.1–21.8
|
29.2
|
18.3–44.3
|
26.5
|
15.4–42.4
|
45.9
|
32.8–62.5
|
Standardised IR
c
|
14.9
|
8.5–21.3
|
6.0
|
2.1–9.9
|
19.1
|
10.8–27.4
|
16.8
|
8.6–25.0
|
27.9
|
18.9–36.9
|
|
2004–2005
|
Crude rate
|
37.0
|
27.5–48.8
|
20.7
|
13.4–30.6
|
28.0
|
18.6–40.5
|
10.5
|
6.0–17.0
|
42.4
|
33.3–53.2
|
Standardised IR
c
|
24.3
|
17.3–31.3
|
12.9
|
7.6–18.2
|
17.1
|
10.2–24.0
|
6.3
|
3.0–9.6
|
27.5
|
20.9–34.1
|
|
Women
|
|||||||||||
2002–2003
|
Crude rate
|
9.6
|
4.6–17.6
|
7.3
|
2.9–15.0
|
12.7
|
6.1–23.3
|
10.5
|
4.2–21.7
|
8.8
|
3.8–17.3
|
Standardised IR
c
|
5.4
|
1.8–9.0
|
3.6
|
0.6–6.6
|
6.3
|
1.8–10.8
|
6.6
|
1.3–11.9
|
3.6
|
0.7–6.5
|
|
2004–2005
|
Crude rate
|
20.5
|
13.7–29.4
|
8.5
|
4.3–15.3
|
14.2
|
8.0–23.5
|
6.9
|
3.5–12.4
|
20.8
|
14.7–28.5
|
Standardised IR
c
|
12.1
|
7.1–17.1
|
3.7
|
1.0–6.4
|
8.5
|
3.4–13.6
|
3.8
|
1.1–6.5
|
12.4
|
8.0–16.8
|
IRR
a
|
95%CI
b
|
p
|
|
---|---|---|---|
2002–2003
|
|||
Gender
|
<0.0001
|
||
Men
|
3.47
|
2.43–4.96
|
|
Women
|
1 (reference)
|
||
Age
|
<0.0001
|
||
< 40
|
0.05
|
0.02–0.13
|
|
40–49
|
0.59
|
0.32–1.06
|
|
50–59
|
1 (reference)
|
||
60–69
|
1.52
|
0.90–2.59
|
|
≥ 70
|
3.50
|
2.25–5.44
|
|
Region
|
0.0003
|
||
Alsace
|
1 (reference)
|
||
Bourgogne
|
0.50
|
0.28–0.89
|
|
Champagne-Ardenne
|
1.22
|
0.75–1.99
|
|
Franche-Comté
|
1.07
|
0.63–1.81
|
|
Lorraine
|
1.61
|
1.03–2.51
|
|
2004–2005
|
|||
Gender
|
<0.0001
|
||
Men
|
2.32
|
1.83–2.95
|
|
Women
|
1 (reference)
|
||
Age
|
<0.0001
|
||
< 40
|
0.08
|
0.05–0.13
|
|
40–49
|
0.44
|
0.28–0.69
|
|
50–59
|
1 (reference)
|
||
60–69
|
1.84
|
1.30–2.60
|
|
≥ 70
|
2.60
|
1.91–3.56
|
|
Region
|
<0.0001
|
||
Alsace
|
1 (reference)
|
||
Bourgogne
|
0.42
|
0.28–0.62
|
|
Champagne-Ardenne
|
0.68
|
0.47–0.99
|
|
Franche-Comté
|
0.28
|
0.18–0.43
|
|
Lorraine
|
1.03
|
0.77–1.38
|
Follow-up at 6 months
2002–2003 (
n = 33)
|
2004–2005 (
n = 53)
|
|||||
---|---|---|---|---|---|---|
n
|
%
|
95% CI
a
|
n
|
%
|
95% CI
a
|
|
Squamous cell carcinoma
|
16
|
48.5
|
41.2–55.8
|
22
|
41.5
|
36.2–47.1
|
Adenocarcinoma
|
12
|
36.4
|
29.6–43.7
|
18
|
34.0
|
28.9–39.5
|
Large-cell lung carcinoma
|
2
|
6.1
|
2.9–11.5
|
4
|
7.5
|
4.8–11.6
|
Small-cell lung carcinoma
|
1
|
3.0
|
0.9–8.0
|
2
|
3.8
|
1.8–7.3
|
Undetermined
|
2
|
6.1
|
2.9–11.5
|
7
|
13.2
|
9.7–17.8
|