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Digestive Diseases and Sciences
Erschienen in: Digestive Diseases and Sciences 12/2016

14.10.2016 | Original Article

Increased Proliferative Activity Accompanies the Local Inflammatory Response of Gastric Mucosa After Intragastric Balloon Insertion

verfasst von: Ehab Atef, Khaled Refaat Zalata, Hoda Atef, Ahmed A. M. Abdel-Hamid

Erschienen in: Digestive Diseases and Sciences | Ausgabe 12/2016

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Abstract

Background and Aim

The use of BioEnterics intragastric balloon (BIB) is progressively increasing, owing to the fact that morbid obesity becomes a global epidemic together with risks of bariatric surgery. Yet, the possible local BIB effect on gastric mucosa is not clearly elucidated. The aim of the current study was to assess the histological changes occurring in the gastric mucosa post-BIB insertion.

Methods

Gastric mucosa biopsy was obtained from 87 cases of morbid obesity both pre-BIB and 6 months post-BIB insertion to compare the local changes by histological and immunohistochemical analysis.

Results

An inflammatory reaction was detected in the post-BIB mucosa which displayed a positive CD20, CD3 (p < 0.05), and the proliferation index (Ki67) increased significantly compared with that of the pre-BIB cases. The Ki67 index showed a significant positive correlation with CD20 and CD3 immunoexpression in the post-BIB gastric mucosae.

Conclusion

Our results demonstrated a possible increase in the gastric proliferative activity after BIB insertion accompanied with a remarkable local inflammatory reaction. Although these findings may be reactive and transient, endoscopic follow-up is recommended for early detection of further pathological changes.
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Metadaten
Titel
Increased Proliferative Activity Accompanies the Local Inflammatory Response of Gastric Mucosa After Intragastric Balloon Insertion
verfasst von
Ehab Atef
Khaled Refaat Zalata
Hoda Atef
Ahmed A. M. Abdel-Hamid
Publikationsdatum
14.10.2016
Verlag
Springer US
Erschienen in
Digestive Diseases and Sciences / Ausgabe 12/2016
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-016-4344-6

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