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European Radiology

Erschienen in:

04.08.2021 | Head and Neck

Influence of post-label delay time on the performance of 3D pseudo-continuous arterial spin labeling magnetic resonance imaging in the characterization of parotid gland tumors

verfasst von: Hao Hu, Lu Chen, Liu-Ning Zhu, Wei Chen, Guo-Yi Su, Weiqiang Dou, Shou-Shan Bu, Fei-Yun Wu, Xiao-Quan Xu

Erschienen in: European Radiology | Ausgabe 2/2022

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Abstract

Objective

To evaluate the influence of post-label delay times (PLDs) on the performance of 3D pseudo-continuous arterial spin labeling (pCASL) magnetic resonance imaging for characterizing parotid gland tumors and to explore the optimal PLDs for the differential diagnosis.

Materials and method

Fifty-eight consecutive patients with parotid gland tumors were enrolled, including 33 patients with pleomorphic adenomas (PAs), 16 patients with Warthin’s tumors (WTs), and 9 patients with malignant tumors (MTs). 3D pCASL was scanned for each patient five times, with PLDs of 1025 ms, 1525 ms, 2025 ms, 2525 ms, and 3025 ms. Tumor blood flow (TBF) was calculated, and compared among different PLDs and tumor groups. Performance of TBF at different PLDs was evaluated using receiver operating characteristic analysis.

Results

With an increasing PLD, TBF tended to gradually increase in PAs (p < 0.001), while TBF tended to slightly increase and then gradually decrease in WTs (p = 0.001), and PAs showed significantly lower TBF than WTs at all 5 PLDs (p < 0.05). PAs showed significantly lower TBF than MTs at 4 PLDs (p < 0.05), except at 3025 ms (p = 0.062). WTs showed higher TBF than MTs at all 5 PLDs; however, differences did not reach significance (p > 0.05). Setting a TBF of 64.350 mL/100g/min at a PLD of 1525 ms, or a TBF of 23.700 mL/100g/min at a PLD of 1025 ms as the cutoff values, optimal performance could be obtained for differentiating PAs from WTs (AUC = 0.905) or from MTs (AUC = 0.872).

Conclusions

Short PLDs (1025 ms or 1525 ms) are suggested to be used in 3D pCASL for characterizing parotid gland tumors in clinical practice.

Key Points

• With 5 different PLDs, 3D pCASL can reflect the variation of blood flow in parotid gland tumors.

• 3D pCASL is useful for characterizing PAs from WTs or MTs.

• Short PLDs (1025 ms or 1525 ms) are suggested to be used in 3D pCASL for characterizing parotid gland tumors in clinical practice.

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Titel: Influence of post-label delay time on the performance of 3D pseudo-continuous arterial spin labeling magnetic resonance imaging in the characterization of parotid gland tumors
verfasst von: Hao Hu
Lu Chen
Liu-Ning Zhu
Wei Chen
Guo-Yi Su
Weiqiang Dou
Shou-Shan Bu
Fei-Yun Wu
Xiao-Quan Xu
Publikationsdatum: 04.08.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 2/2022
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-021-08220-1

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Influence of post-label delay time on the performance of 3D pseudo-continuous arterial spin labeling magnetic resonance imaging in the characterization of parotid gland tumors