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Endocrine
Erschienen in: Endocrine 3/2016

21.10.2016 | Original Article

Insulin resistance elicited in postpubertal primate offspring deprived of estrogen in utero

verfasst von: Gerald J. Pepe, Adina Maniu, Graham Aberdeen, Terrie J. Lynch, Soon Ok Kim, Jerry Nadler, Eugene D. Albrecht

Erschienen in: Endocrine | Ausgabe 3/2016

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Abstract

We recently demonstrated that offspring delivered to baboons deprived of estrogen during the second half of gestation exhibited insulin resistance prior to onset of puberty. Because gonadal hormones have a profound effect on insulin action and secretion in adults, we determined whether insulin resistance is retained after initiation of gonadal secretion of testosterone and estradiol. Glucose tolerance tests were performed in postpubertal baboon offspring of untreated and letrozole-treated animals (serum estradiol reduced >95 %). Basal fasting levels of insulin (P < 0.05) and peak 1 min and 1 + 3 + 5 min levels of glucose after glucose tolerance tests challenge (P < 0.03) were greater in offspring delivered to letrozole-treated, estrogen-deprived baboons than untreated animals. Moreover, the value for the HOMA-IR, an accepted index of insulin resistance, was 2-fold greater (P < 0.05) in offspring delivered to baboons treated with letrozole than in untreated animals. Collectively these results support the proposal that estrogen normally has an important role in programming mechanisms in utero within the developing fetus that lead to insulin sensitivity after birth.
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Metadaten
Titel
Insulin resistance elicited in postpubertal primate offspring deprived of estrogen in utero
verfasst von
Gerald J. Pepe
Adina Maniu
Graham Aberdeen
Terrie J. Lynch
Soon Ok Kim
Jerry Nadler
Eugene D. Albrecht
Publikationsdatum
21.10.2016
Verlag
Springer US
Erschienen in
Endocrine / Ausgabe 3/2016
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-016-1145-9

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