Erschienen in:
01.04.2003 | Laboratory Investigation
Intense Inflammatory Reaction to Heparin Polymer Coated
Intravascular Palmaz Stents in Porcine Arteries Compared to Uncoated
Palmaz Stents
verfasst von:
Scott C. Goodwin, Hyo-Chun Yoon, Gary Chen, Peter Abdel-Sayed, Mary M. Costantino, Sheila M. Bonilla, Earl Nishimura
Erschienen in:
CardioVascular and Interventional Radiology
|
Ausgabe 2/2003
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Abstract
The objective of this study was to evaluate the
efficacy of heparin-polymer-coated intravascular stents in the
reduction of vessel stenosis. Three types of coatings for Palmaz stents
were tested: 1) heparin covalently bound to a polyethylene oxide
(Hp-PEO) tether; 2) heparin copolymerized with ethylene vinyl acetate
(Hp-Elvax) and 3) Elvax alone. Polymer-coated stents and uncoated
controls were deployed in the external iliac arteries following
endothelial injury in 18 swine. The animals were maintained on an
atherogenic diet and examined by angiography at 6 and 12 weeks. The
stented segments were then harvested for histopathologic analysis. Both
types of heparin-coated stents resulted in increased luminal narrowing
as compared to the contralateral uncoated stents. At 6 weeks, average
luminal stenosis was 48% for Hp-PEO stents vs 35% for uncoated stents
(p < 0.05). At 12 weeks, average luminal
stenosis was 36% for Hp-PEO stents vs 26% for uncoated stents
(p = NS). For Hp-Elvax stents, the average
stenosis was 58% vs 33% for uncoated controls (p <
0.05) at 6 weeks and 47% vs 19% for uncoated controls
(p < 0.05) at 12 weeks. There was no
significant difference between Hp-Elvax stents and Elvax stents
(p = NS). Increased luminal narrowing in coated
stents was primarily secondary to a marked inflammatory response.
Heparin-polyethylene oxide and heparin-ethylene vinyl acetate-coated
stents resulted in increased luminal narrowing as compared with
uncoated stents, due to a marked inflammatory response.