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01.07.2014 | Original Article

Intensity Based Methods for Brain MRI Longitudinal Registration. A Study on Multiple Sclerosis Patients

verfasst von: Yago Diez, Arnau Oliver, Mariano Cabezas, Sergi Valverde, Robert Martí, Joan Carles Vilanova, Lluís Ramió-Torrentà, Àlex Rovira, Xavier Lladó

Erschienen in: Neuroinformatics | Ausgabe 3/2014

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Abstract

Registration is a key step in many automatic brain Magnetic Resonance Imaging (MRI) applications. In this work we focus on longitudinal registration of brain MRI for Multiple Sclerosis (MS) patients. First of all, we analyze the effect that MS lesions have on registration by synthetically eliminating some of the lesions. Our results show how a widely used method for longitudinal registration such as rigid registration is practically unconcerned by the presence of MS lesions while several non-rigid registration methods produce outputs that are significantly different. We then focus on assessing which is the best registration method for longitudinal MRI images of MS patients. In order to analyze the results obtained for all studied criteria, we use both descriptive statistics and statistical inference: one way ANOVA, pairwise t-tests and permutation tests.

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Titel: Intensity Based Methods for Brain MRI Longitudinal Registration. A Study on Multiple Sclerosis Patients
verfasst von: Yago Diez
Arnau Oliver
Mariano Cabezas
Sergi Valverde
Robert Martí
Joan Carles Vilanova
Lluís Ramió-Torrentà
Àlex Rovira
Xavier Lladó
Publikationsdatum: 01.07.2014
Verlag: Springer US
Erschienen in: Neuroinformatics / Ausgabe 3/2014
Print ISSN: 1539-2791
Elektronische ISSN: 1559-0089
DOI: https://doi.org/10.1007/s12021-013-9216-z

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