nach oben

Langenbeck's Archives of Surgery

Erschienen in:

01.09.2009 | Current Concepts in Endocrine Surgery

Intraoperative adjuncts in surgery for primary hyperparathyroidism

verfasst von: Barney J. Harrison, Frederic Triponez

Erschienen in: Langenbeck's Archives of Surgery | Ausgabe 5/2009

Einloggen, um Zugang zu erhalten

Abstract

Purpose

This paper is a review of the evidence base to produce recommendations for the use of intraoperative parathyroid hormone (PTH), radioguided parathyroidectomy (RGP), methylene blue (MB), frozen section, and intraoperative neuromonitoring during surgery for primary hyperparathyroidism (PHPT).

Materials and methods

A Medline keyword search of English-language articles led to the production of a draft document, subsequently revised by committee, containing levels of evidence and the grading of recommendations as proposed by the Agency for Healthcare Research and Quality.

Results

Literature review provides the basis for clear recommendations on the use of intraoperative PTH at surgery for PHPT. There is little evidence to support the use of RGP, MB, routine frozen section, and intraoperative neuromonitoring.

Nur mit Berechtigung zugänglich

Sackett WR, Barraclough B, Reeve TS, Delbridge LW (2002) Worldwide trends in the surgical treatment of primary hyperparathyroidism in the era of minimally invasive parathyroidectomy. Arch Surg 137(9):1055–1059PubMedCrossRef

Sharma J, Milas M, Berber E, Mazzaglia P, Siperstein A, Weber CJ (2008) Value of intraoperative parathyroid hormone monitoring. Ann Surg Oncol 15(2):493–498PubMedCrossRef

Miccoli P, Berti P, Materazzi G, Ambrosini CE, Fregoli L, Donatini G (2008) Endoscopic bilateral neck exploration versus quick intraoperative parathormone assay (qPTHa) during endoscopic parathyroidectomy: a prospective randomized trial. Surg Endosc 22(2):398–400PubMedCrossRef

Barczynski M, Cichon S, Konturek A, Cichon W (2006) Minimally invasive video-assisted parathyroidectomy versus open minimally invasive parathyroidectomy for a solitary parathyroid adenoma: a prospective, randomized, blinded trial. World J Surg 30(5):721–731PubMedCrossRef

Baliski CR, Stewart JK, Anderson DW, Wiseman SM, Bugis SP (2005) Selective unilateral parathyroid exploration: an effective treatment for primary hyperparathyroidism. Am J Surg 189(5):596–600 discussion 600PubMedCrossRef

Sidhu S, Neill AK, Russell CF (2003) Long-term outcome of unilateral parathyroid exploration for primary hyperparathyroidism due to presumed solitary adenoma. World J Surg 27(3):339–342PubMedCrossRef

Russell CF, Dolan SJ, Laird JD (2006) Randomized clinical trial comparing scan-directed unilateral versus bilateral cervical exploration for primary hyperparathyroidism due to solitary adenoma. Br J Surg 93(4):418–421PubMedCrossRef

Udelsman R, Donovan PI (2004) Open minimally invasive parathyroid surgery. World J Surg 28(12):1224–1226PubMedCrossRef

Bergson EJ, Sznyter LA, Dubner S, Palestro CJ, Heller KS (2004) Sestamibi scans and intraoperative parathyroid hormone measurement in the treatment of primary hyperparathyroidism. Arch Otolaryngol Head Neck Surg 130(1):87–91PubMedCrossRef

10.

Carneiro-Pla DM, Solorzano CC, Irvin GL 3rd (2006) Consequences of targeted parathyroidectomy guided by localization studies without intraoperative parathyroid hormone monitoring. J Am Coll Surg 202(5):715–722PubMedCrossRef

11.

Nilsen FS, Haug E, Heidemann M, Karlsen SJ (2006) Does rapid intraoperative parathyroid hormone analysis predict cure in patients undergoing surgery for primary hyperparathyroidism? A prospective study. Scand J Surg 95(1):28–32PubMed

12.

Gil-Cardenas A, Gamino R, Reza A, Pantoja JP, Herrera MF (2007) Is intraoperative parathyroid hormone assay mandatory for the success of targeted parathyroidectomy? J Am Coll Surg 204(2):286–290PubMedCrossRef

13.

Stalberg P, Sidhu S, Sywak M, Robinson B, Wilkinson M, Delbridge L (2006) Intraoperative parathyroid hormone measurement during minimally invasive parathyroidectomy: does it “value-add” to decision-making? J Am Coll Surg 203(1):1–6PubMedCrossRef

14.

Gawande AA, Monchik JM, Abbruzzese TA, Iannuccilli JD, Ibrahim SI, Moore FD Jr (2006) Reassessment of parathyroid hormone monitoring during parathyroidectomy for primary hyperparathyroidism after 2 preoperative localization studies. Arch Surg 141(4):381–384 discussion 384PubMedCrossRef

15.

Mihai R, Palazzo FF, Gleeson FV, Sadler GP (2007) Minimally invasive parathyroidectomy without intraoperative parathyroid hormone monitoring in patients with primary hyperparathyroidism. Br J Surg 94(1):42–47PubMedCrossRef

16.

Pang T, Stalberg P, Sidhu S, Sywak M, Wilkinson M, Reeve TS, Delbridge L (2007) Minimally invasive parathyroidectomy using the lateral focused mini-incision technique without intraoperative parathyroid hormone monitoring. Br J Surg 94(3):315–319PubMedCrossRef

17.

Lew JI, Solorzano CC, Montano RE, Carneiro-Pla DM, Irvin GL 3rd (2008) Role of intraoperative parathormone monitoring during parathyroidectomy in patients with discordant localization studies. Surgery 144(2):299–306PubMedCrossRef

18.

Barczynski M, Konturek A, Cichon S, Hubalewska-Dydejczyk A, Golkowski F, Huszno B (2007) Intraoperative parathyroid hormone assay improves outcomes of minimally invasive parathyroidectomy mainly in patients with a presumed solitary parathyroid adenoma and missing concordance of preoperative imaging. Clin Endocrinol (Oxf) 66(6):878–885CrossRef

19.

Ito F, Sippel R, Lederman J, Chen H (2007) The utility of intraoperative bilateral internal jugular venous sampling with rapid parathyroid hormone testing. Ann Surg 245(6):959–963PubMedCrossRef

20.

Irvin GL 3rd, Solorzano CC, Carneiro DM (2004) Quick intraoperative parathyroid hormone assay: surgical adjunct to allow limited parathyroidectomy, improve success rate, and predict outcome. World J Surg 28(12):1287–1292PubMedCrossRef

21.

Richards ML, Thompson GB, Farley DR, Grant CS (2008) Reoperative parathyroidectomy in 228 patients during the era of minimal-access surgery and intraoperative parathyroid hormone monitoring. Am J Surg 196(6):937–942 discussion 942–933PubMedCrossRef

22.

Yen TW, Wang TS, Doffek KM, Krzywda EA, Wilson SD (2008) Reoperative parathyroidectomy: an algorithm for imaging and monitoring of intraoperative parathyroid hormone levels that results in a successful focused approach. Surgery 144(4):611–619 discussion 619–621PubMedCrossRef

23.

Carter AB, Howanitz PJ (2003) Intraoperative testing for parathyroid hormone: a comprehensive review of the use of the assay and the relevant literature. Arch Pathol Lab Med 127(11):1424–1442PubMed

24.

Bieglmayer C, Prager G, Niederle B (2002) Kinetic analyses of parathyroid hormone clearance as measured by three rapid immunoassays during parathyroidectomy. Clin Chem 48(10):1731–1738PubMed

25.

Woodrum DT, Saunders BD, England BG, Burney RE, Doherty GM, Gauger PG (2004) The influence of sample site on intraoperative PTH monitoring during parathyroidectomy. Surgery 136(6):1169–1175PubMedCrossRef

26.

De Vos tot Nederveen Cappel R, Bouvy N, de Herder W, de Rijke Y, van Toor H, Bonjer J (2007) Novel criteria for parathyroid hormone levels in parathyroid hormone-guided parathyroid surgery. Arch Pathol Lab Med 131(12):1800–1804

27.

Miller BS, England BG, Nehs M, Burney RE, Doherty GM, Gauger PG (2006) Interpretation of intraoperative parathyroid hormone monitoring in patients with baseline parathyroid hormone levels of <100 pg/mL. Surgery 140(6):883–889 discussion 889–890PubMedCrossRef

28.

Agarwal G, Barakate MS, Robinson B, Wilkinson M, Barraclough B, Reeve TS, Delbridge LW (2001) Intraoperative quick parathyroid hormone versus same-day parathyroid hormone testing for minimally invasive parathyroidectomy: a cost-effectiveness study. Surgery 130(6):963–970PubMedCrossRef

29.

Gauger PG, Mullan MH, Thompson NW, Doherty GM, Matz KA, England BG (2004) An alternative analysis of intraoperative parathyroid hormone data may improve the ability to detect multiglandular disease. Arch Surg 139(2):164–169PubMedCrossRef

30.

Karakousis GC, Han D, Kelz RR, Nemani D, Karamacharya J, Roses R, Gimotty PA, Fraker DL (2007) Interpretation of intra-operative PTH changes in patients with multi-glandular primary hyperparathyroidism (pHPT). Surgery 142(6):845–850 discussion 850 and 841–842PubMedCrossRef

31.

Riss P, Kaczirek K, Heinz G, Bieglmayer C, Niederle B (2007) A “defined baseline” in PTH monitoring increases surgical success in patients with multiple gland disease. Surgery 142(3):398–404PubMedCrossRef

32.

Siperstein A, Berber E, Barbosa GF, Tsinberg M, Greene AB, Mitchell J, Milas M (2008) Predicting the success of limited exploration for primary hyperparathyroidism using ultrasound, sestamibi, and intraoperative parathyroid hormone: analysis of 1158 cases. Ann Surg 248(3):420–428PubMed

33.

Carneiro DM, Solorzano CC, Nader MC, Ramirez M, Irvin GL 3rd (2003) Comparison of intraoperative iPTH assay (QPTH) criteria in guiding parathyroidectomy: which criterion is the most accurate? Surgery 134(6):973–979 discussion 979–981PubMedCrossRef

34.

Inabnet WB (2004) Intraoperative parathyroid hormone monitoring. World J Surg 28(12):1212–1215PubMedCrossRef

35.

Rolighed L, Heickendorff L, Hessov I, Garne JP, Rodt SA, Christiansen P (2004) Primary hyperparathyroidism: intraoperative PTH-measurements. Scand J Surg 93(1):43–47PubMed

36.

Di Stasio E, Carrozza C, Pio Lombardi C, Raffaelli M, Traini E, Bellantone R, Zuppi C (2007) Parathyroidectomy monitored by intra-operative PTH: the relevance of the 20 min end-point. Clin Biochem 40(9–10):595–603PubMed

37.

Emmolo I, Corso HD, Borretta G, Visconti G, Piovesan A, Cesario F, Borghi F (2005) Unexpected results using rapid intraoperative parathyroid hormone monitoring during parathyroidectomy for primary hyperparathyroidism. World J Surg 29(6):785–788PubMedCrossRef

38.

Phillips IJ, Kurzawinski TR, Honour JW (2005) Potential pitfalls in intraoperative parathyroid hormone measurements during parathyroid surgery. Ann Clin Biochem 42(Pt 6):453–458PubMedCrossRef

39.

Mozzon M, Mortier PE, Jacob PM, Soudan B, Boersma AA, Proye CA (2004) Surgical management of primary hyperparathyroidism: the case for giving up quick intraoperative PTH assay in favor of routine PTH measurement the morning after. Ann Surg 240(6):949–953 discussion 953–944PubMedCrossRef

40.

Lombardi CP, Raffaelli M, Traini E, Di Stasio E, Carrozza C, De Crea C, Zuppi C, Bellantone R (2008) Intraoperative PTH monitoring during parathyroidectomy: the need for stricter criteria to detect multiglandular disease. Langenbecks Arch Surg 393(5):639–645PubMedCrossRef

41.

Weber KJ, Misra S, Lee JK, Wilhelm SW, DeCresce R, Prinz RA (2004) Intraoperative PTH monitoring in parathyroid hyperplasia requires stricter criteria for success. Surgery 136(6):1154–1159PubMedCrossRef

42.

McGill J, Sturgeon C, Kaplan SP, Chiu B, Kaplan EL, Angelos P (2008) How does the operative strategy for primary hyperparathyroidism impact the findings and cure rate? A comparison of 800 parathyroidectomies. J Am Coll Surg 207(2):246–249PubMedCrossRef

43.

Gauger PG, Agarwal G, England BG, Delbridge LW, Matz KA, Wilkinson M, Robinson BG, Thompson NW (2001) Intraoperative parathyroid hormone monitoring fails to detect double parathyroid adenomas: a 2-institution experience. Surgery 130(6):1005–1010PubMedCrossRef

44.

Clerici T, Brandle M, Lange J, Doherty GM, Gauger PG (2004) Impact of intraoperative parathyroid hormone monitoring on the prediction of multiglandular parathyroid disease. World J Surg 28(2):187–192PubMedCrossRef

45.

Carneiro DM, Irvin GL 3rd (2000) Late parathyroid function after successful parathyroidectomy guided by intraoperative hormone assay (QPTH) compared with the standard bilateral neck exploration. Surgery 128(6):925–929 discussion 935–926PubMedCrossRef

46.

Westerdahl J, Bergenfelz A (2006) Parathyroid surgical failures with sufficient decline of intraoperative parathyroid hormone levels: unobserved multiple endocrine neoplasia as an explanation. Arch Surg 141(6):589–594PubMedCrossRef

47.

Norman J, Denham D (1998) Minimally invasive radioguided parathyroidectomy in the reoperative neck. Surgery 124(6):1088–1092 discussion 1092–1083PubMedCrossRef

48.

Chen H, Mack E, Starling JR (2005) A comprehensive evaluation of perioperative adjuncts during minimally invasive parathyroidectomy: which is most reliable? Ann Surg 242(3):375–380 discussion 380–373PubMed

49.

Rubello D, Casara D, Giannini S, Piotto A, De Carlo E, Muzzio PC, Pelizzo MR (2003) Importance of radio-guided minimally invasive parathyroidectomy using hand-held gamma probe and low (99m)Tc-MIBI dose. Technical considerations and long-term clinical results. Q J Nucl Med 47(2):129–138PubMed

50.

Mariani G, Gulec SA, Rubello D, Boni G, Puccini M, Pelizzo MR, Manca G, Casara D, Sotti G, Erba P, Volterrani D, Giuliano AE (2003) Preoperative localization and radioguided parathyroid surgery. J Nucl Med 44(9):1443–1458PubMed

51.

Inabnet WB 3rd, Kim CK, Haber RS, Lopchinsky RA (2002) Radioguidance is not necessary during parathyroidectomy. Arch Surg 137(8):967–970PubMedCrossRef

52.

Chen H, Mack E, Starling JR (2003) Radioguided parathyroidectomy is equally effective for both adenomatous and hyperplastic glands. Ann Surg 238(3):332–337 discussion 337–338PubMed

53.

Goldstein RE, Billheimer D, Martin WH, Richards K (2003) Sestamibi scanning and minimally invasive radioguided parathyroidectomy without intraoperative parathyroid hormone measurement. Ann Surg 237(5):722–730 discussion 730–721PubMedCrossRef

54.

Jaskowiak NT, Sugg SL, Helke J, Koka MR, Kaplan EL (2002) Pitfalls of intraoperative quick parathyroid hormone monitoring and gamma probe localization in surgery for primary hyperparathyroidism. Arch Surg 137(6):659–668 discussion 668–659PubMedCrossRef

55.

Schachter PP, Issa N, Shimonov M, Czerniak A, Lorberboym M (2004) Early, postinjection MIBI-SPECT as the only preoperative localizing study for minimally invasive parathyroidectomy. Arch Surg 139(4):433–437PubMedCrossRef

56.

Casara D, Rubello D, Pelizzo MR, Shapiro B (2001) Clinical role of 99mTcO4/MIBI scan, ultrasound and intra-operative gamma probe in the performance of unilateral and minimally invasive surgery in primary hyperparathyroidism. Eur J Nucl Med 28(9):1351–1359PubMedCrossRef

57.

Burkey SH, Van Heerden JA, Farley DR, Thompson GB, Grant CS, Curlee KJ (2002) Will directed parathyroidectomy utilizing the gamma probe or intraoperative parathyroid hormone assay replace bilateral cervical exploration as the preferred operation for primary hyperparathyroidism? World J Surg 26(8):914–920PubMedCrossRef

58.

McGreal G, Winter DC, Sookhai S, Evoy D, Ryan M, O’Sullivan GC, Redmond HP (2001) Minimally invasive, radioguided surgery for primary hyperparathyroidism. Ann Surg Oncol 8(10):856–860PubMedCrossRef

59.

Norman J, Chheda H (1997) Minimally invasive parathyroidectomy facilitated by intraoperative nuclear mapping. Surgery 122(6):998–1003 discussion 1003–1004PubMedCrossRef

60.

Farley DR (2004) Technetium-99m 2-methoxyisobutyl isonitrile-scintigraphy: preoperative and intraoperative guidance for primary hyperparathyroidism. World J Surg 28(12):1207–1211PubMedCrossRef

61.

Bozkurt MF, Ugur O, Hamaloglu E, Sayek I, Gulec SA (2003) Optimization of the gamma probe-guided parathyroidectomy. Am Surg 69(8):720–725PubMed

62.

Friedman M, Gurpinar B, Schalch P, Joseph NJ (2007) Guidelines for radioguided parathyroid surgery. Arch Otolaryngol Head Neck Surg 133(12):1235–1239PubMedCrossRef

63.

Ugur O, Bozkurt MF, Hamaloglu E, Sokmensuer C, Etikan I, Ugur Y, Sayek I, Gulec SA (2004) Clinicopathologic and radiopharmacokinetic factors affecting gamma probe-guided parathyroidectomy. Arch Surg 139(11):1175–1179PubMedCrossRef

64.

Caudle AS, Brier SE, Calvo BF, Kim HJ, Meyers MO, Ollila DW (2006) Experienced radio-guided surgery teams can successfully perform minimally invasive radio-guided parathyroidectomy without intraoperative parathyroid hormone assays. Am Surg 72(9):785–789 discussion 790PubMed

65.

Murphy C, Norman J (1999) The 20% rule: a simple, instantaneous radioactivity measurement defines cure and allows elimination of frozen sections and hormone assays during parathyroidectomy. Surgery 126(6):1023–1028 discussion 1028–1029PubMedCrossRef

66.

Hanif F, Coffey JC, Romics L Jr, O’Sullivan K, Aftab F, Redmond HP (2006) Rapid intraoperative parathyroid hormone assay—more than just a comfort measure. World J Surg 30(2):156–161PubMedCrossRef

67.

Rubello D, Piotto A, Casara D, Muzzio PC, Shapiro B, Pelizzo MR (2003) Role of gamma probes in performing minimally invasive parathyroidectomy in patients with primary hyperparathyroidism: optimization of preoperative and intraoperative procedures. Eur J Endocrinol 149(1):7–15PubMedCrossRef

68.

Norman J, Politz D (2008) Measuring individual parathyroid gland hormone production in real-time during radioguided parathyroidectomy. Experience in over 8,000 operations. Minerva Endocrinol 33(3):147–157PubMed

69.

Rubello D, Mariani G, Pelizzo MR (2007) Minimally invasive radio-guided parathyroidectomy on a group of 452 primary hyperparathyroid patients: refinement of preoperative imaging and intraoperative procedure. Nuklearmedizin 46(3):85–92PubMed

70.

Perrier ND, Ituarte PH, Morita E, Hamill T, Gielow R, Duh QY, Clark OH (2002) Parathyroid surgery: separating promise from reality. J Clin Endocrinol Metab 87(3):1024–1029PubMedCrossRef

71.

Fahy BN, Bold RJ, Beckett L, Schneider PD (2002) Modern parathyroid surgery: a cost-benefit analysis of localizing strategies. Arch Surg 137(8):917–922 discussion 922–913PubMedCrossRef

72.

Geelhoed GW, Silverberg SG (1984) Intraoperative imprints for the identification of parathyroid tissue. Surgery 96(6):1124–1131PubMed

73.

Shidham VB, Asma Z, Rao RN, Chavan A, Machhi J, Almagro U, Komorowski RA (2002) Intraoperative cytology increases the diagnostic accuracy of frozen sections for the confirmation of various tissues in the parathyroid region. Am J Clin Pathol 118(6):895–902PubMedCrossRef

74.

Hosking SW, Jones H, du Boulay CE, McGinn FP (1993) Surgery for parathyroid adenoma and hyperplasia: relationship of histology to outcome. Head Neck 15(1):24–28PubMedCrossRef

75.

Saxe AW, Baier R, Tesluk H, Toreson W (1985) The role of the pathologist in the surgical treatment of hyperparathyroidism. Surg Gynecol Obstet 161(2):101–105PubMed

76.

Westra WH, Pritchett DD, Udelsman R (1998) Intraoperative confirmation of parathyroid tissue during parathyroid exploration: a retrospective evaluation of the frozen section. Am J Surg Pathol 22(5):538–544PubMedCrossRef

77.

Anton RC, Wheeler TM (2005) Frozen section of thyroid and parathyroid specimens. Arch Pathol Lab Med 129(12):1575–1584PubMed

78.

Baloch ZW, LiVolsi VA (2002) Intraoperative assessment of thyroid and parathyroid lesions. Semin Diagn Pathol 19(4):219–226PubMed

79.

Boggs JE, Irvin GL 3rd, Carneiro DM, Molinari AS (1999) The evolution of parathyroidectomy failures. Surgery 126(6):998–1002 discussion 1002–1003PubMed

80.

Levin KE, Clark OH (1989) The reasons for failure in parathyroid operations. Arch Surg 124(8):911–914 discussion 914–915PubMed

81.

Robertson GS, Iqbal SJ, Bolia A, Bell PR, Veitch PS (1992) Intraoperative parathyroid hormone estimation: a valuable adjunct to parathyroid surgery. Ann R Coll Surg Engl 74(1):19–22PubMed

82.

Roslyn JJ, Mulder DG, Gordon HE (1981) Persistent and recurrent hyperparathyroidism. Am J Surg 142(1):21–25PubMedCrossRef

83.

Elliott DD, Monroe DP, Perrier ND (2006) Parathyroid histopathology: is it of any value today? J Am Coll Surg 203(5):758–765PubMedCrossRef

84.

Perrier ND, Ituarte P, Kikuchi S, Siperstein AE, Duh QY, Clark OH, Gielow R, Hamill T (2000) Intraoperative parathyroid aspiration and parathyroid hormone assay as an alternative to frozen section for tissue identification. World J Surg 24(11):1319–1322PubMedCrossRef

85.

Chan RK, Ibrahim SI, Pil P, Tanasijevic M, Moore FD (2005) Validation of a method to replace frozen section during parathyroid exploration by using the rapid parathyroid hormone assay on parathyroid aspirates. Arch Surg 140(4):371–373PubMedCrossRef

86.

Lo CY, Chan WF, Leung P, Luk JM (2005) Applicability of tissue aspirate for quick parathyroid hormone assay to confirm parathyroid tissue identity during parathyroidectomy for primary hyperparathyroidism. Arch Surg 140(2):146–149 discussion 150PubMedCrossRef

87.

Conrad DN, Olson JE, Hartwig HM, Mack E, Chen H (2006) A prospective evaluation of novel methods to intraoperatively distinguish parathyroid tissue utilizing a parathyroid hormone assay. J Surg Res 133(1):38–41PubMedCrossRef

88.

Dewan AK, Kapadia SB, Hollenbeak CS, Stack BC Jr (2005) Is routine frozen section necessary for parathyroid surgery? Otolaryngol Head Neck Surg 133(6):857–862PubMedCrossRef

89.

Dudley NE (1971) Methylene blue for rapid identification of the parathyroids. Br Med J 3(5776):680–681PubMedCrossRef

90.

Bambach CP, Reeve TS (1978) Parathyroid identification by methylene blue infusion. Aust N Z J Surg 48(3):314–317PubMedCrossRef

91.

Devine RM, van Heerden JA, Grant CS, Muir JJ (1983) The role of methylene blue infusion in the management of persistent or recurrent hyperparathyroidism. Surgery 94(6):916–918PubMed

92.

Gordon DL, Airan MC, Thomas W, Seidman LH (1975) Parathyroid identification by methylene blue infusion. Br J Surg 62(9):747–749PubMedCrossRef

93.

Kuriloff DB, Sanborn KV (2004) Rapid intraoperative localization of parathyroid glands utilizing methylene blue infusion. Otolaryngol Head Neck Surg 131(5):616–622PubMedCrossRef

94.

Orloff LA (2001) Methylene blue and sestamibi: complementary tools for localizing parathyroids. Laryngoscope 111(11 Pt 1):1901–1904PubMedCrossRef

95.

Schell SR, Dudley NE (2003) Clinical outcomes and fiscal consequences of bilateral neck exploration for primary idiopathic hyperparathyroidism without preoperative radionuclide imaging or minimally invasive techniques. Surgery 133(1):32–39PubMedCrossRef

96.

Sherlock DJ, Holl-Allen RT (1984) Intravital methylene blue staining of parathyroid glands and tumours. Ann R Coll Surg Engl 66(6):396–398PubMed

97.

Sinha SN, Subramaniam P (1996) Initial parathyroid exploration: current trends in Australia. Aust N Z J Surg 66(5):279–281PubMedCrossRef

98.

Takei H, Iino Y, Endo K, Horiguchi J, Maemura M, Koibuchi Y, Horii Y, Yokoe T, Ishida T, Oyama T, Morishita Y (1999) The efficacy of technetium-99m-MIBI scan and intraoperative methylene blue staining for the localization of abnormal parathyroid glands. Surg Today 29(4):307–312PubMedCrossRef

99.

Traynor S, Adams JR, Andersen P, Everts E, Cohen J (1998) Appropriate timing and velocity of infusion for the selective staining of parathyroid glands by intravenous methylene blue. Am J Surg 176(1):15–17PubMedCrossRef

100.

Wheeler MH, Wade JS (1982) Intraoperative identification of parathyroid glands: appraisal of methylene blue staining. Am J Surg 143(6):713–716PubMedCrossRef

101.

Cox RJ, Moore DB, Wolfman EF Jr (1979) Localization of the parathyroid glands by intraoperative methylene blue staining. Surg Gynecol Obstet 148(5):769–770PubMed

102.

Gavilan J, Gavilan C, Tomas MD (1986) Methylene blue infusion for intraoperative identification of the parathyroid glands. Laryngoscope 96(12):1389–1390PubMed

103.

Derom AF, Wallaert PC, Janzing HM, Derom FE (1993) Intraoperative identification of parathyroid glands with methylene blue infusion. Am J Surg 165(3):380–382PubMedCrossRef

104.

Bland KI, Tidwell S, von Fraunhofer JA, Morris RR, McCoy MT, Wathen RL (1985) Intraoperative localization of parathyroid glands using methylthionine chloride/tetramethylthionine chloride in secondary hyperparathyroidism. Surg Gynecol Obstet 160(1):42–48PubMed

105.

Flynn MB, Bumpous JM, Schill K, McMasters KM (2000) Minimally invasive radioguided parathyroidectomy. J Am Coll Surg 191(1):24–31PubMedCrossRef

106.

Grady JA, Bumpous JM, Fleming MM, Flynn MB, Turbiner E, Lentsch EJ, Ziegler CH (2006) Advantages of a targeted approach in minimally invasive radioguided parathyroidectomy surgery for primary hyperparathyroidism. Laryngoscope 116(3):431–435PubMedCrossRef

107.

Han N, Bumpous JM, Goldstein RE, Fleming MM, Flynn MB (2007) Intra-operative parathyroid identification using methylene blue in parathyroid surgery. Am Surg 73(8):820–823PubMed

108.

Martin RC 2nd, Greenwell D, Flynn MB (2000) Initial neck exploration for untreated hyperparathyroidism. Am Surg 66(3):269–272PubMed

109.

Robert J, Delay D, Buhler L, Garcia A, Spilipoulos A (1998) Methylene blue in surgery of primary hyperparathyroidism. Ann Endocrinol (Paris) 59(1):23–26

110.

Ahmed TS (2006) Methylene blue toxicity following infusion to localize parathyroid adenoma. J Laryngol Otol 120(8):708 author reply 708–709PubMed

111.

Bach KK, Lindsay FW, Berg LS, Howard RS (2004) Prolonged postoperative disorientation after methylene blue infusion during parathyroidectomy. Anesth Analg 99(5):1573–1574 table of contentsPubMedCrossRef

112.

Khan MA, North AP, Chadwick DR (2007) Prolonged postoperative altered mental status after methylene blue infusion during parathyroidectomy: a case report and review of the literature. Ann R Coll Surg Engl 89(2):W9–W11PubMedCrossRef

113.

Majithia A, Stearns MP (2006) Methylene blue toxicity following infusion to localize parathyroid adenoma. J Laryngol Otol 120(2):138–140PubMedCrossRef

114.

Mathew S, Linhartova L, Raghuraman G (2006) Hyperpyrexia and prolonged postoperative disorientation following methylene blue infusion during parathyroidectomy. Anaesthesia 61(6):580–583PubMedCrossRef

115.

Patel AS, Singh-Ranger D, Lowery KA, Crinnion JN (2006) Adverse neurologic effect of methylene blue used during parathyroidectomy. Head Neck 28(6):567–568PubMedCrossRef

116.

Vutskits L, Briner A, Klauser P, Gascon E, Dayer AG, Kiss JZ, Muller D, Licker MJ, Morel DR (2008) Adverse effects of methylene blue on the central nervous system. Anesthesiology 108(4):684–692PubMedCrossRef

117.

Licker M, Diaper J, Robert J, Ellenberger C (2008) Effects of methylene blue on propofol requirement during anaesthesia induction and surgery. Anaesthesia 63(4):352–357PubMedCrossRef

118.

Kartha SS, Chacko CE, Bumpous JM, Fleming M, Lentsch EJ, Flynn MB (2006) Toxic metabolic encephalopathy after parathyroidectomy with methylene blue localization. Otolaryngol Head Neck Surg 135(5):765–768PubMedCrossRef

119.

Sweet G, Standiford SB (2007) Methylene-blue-associated encephalopathy. J Am Coll Surg 204(3):454–458PubMedCrossRef

120.

Martindale SJ, Stedeford JC (2003) Neurological sequelae following methylene blue injection for parathyroidectomy. Anaesthesia 58(10):1041–1042PubMedCrossRef

121.

Shanmugam G (2005) Vasoplegic syndrome—the role of methylene blue. Eur J Cardiothorac Surg 28(5):705–710PubMedCrossRef

122.

Masaki E, Kondo I (1999) Methylene blue, a soluble guanylyl cyclase inhibitor, reduces the sevoflurane minimum alveolar anesthetic concentration and decreases the brain cyclic guanosine monophosphate content in rats. Anesth Analg 89(2):484–489PubMedCrossRef

123.

Evgenov OV, Sveinbjornsson B, Bjertnaes LJ (2001) Continuously infused methylene blue modulates the early cardiopulmonary response to endotoxin in awake sheep. Acta Anaesthesiol Scand 45(10):1246–1254PubMedCrossRef

124.

Allendorf J, DiGorgi M, Spanknebel K, Inabnet W, Chabot J, Logerfo P (2007) 1112 consecutive bilateral neck explorations for primary hyperparathyroidism. World J Surg 31(11):2075–2080PubMedCrossRef

125.

Udelsman R (2002) Six hundred fifty-six consecutive explorations for primary hyperparathyroidism. Ann Surg 235(5):665–670 discussion 670–662PubMedCrossRef

126.

Bergenfelz A, Jansson S, Martensson H, Reihner E, Wallin G, Kristoffersson A, Lausen I (2007) Scandinavian Quality Register for Thyroid and Parathyroid Surgery: audit of surgery for primary hyperparathyroidism. Langenbecks Arch Surg 392(4):445–451PubMedCrossRef

127.

Barwell J, Lytle J, Page R, Wilkins D (1997) The NIM-2 nerve integrity monitor in thyroid and parathyroid surgery. Br J Surg 84(6):854PubMedCrossRef

128.

Brennan J, Moore EJ, Shuler KJ (2001) Prospective analysis of the efficacy of continuous intraoperative nerve monitoring during thyroidectomy, parathyroidectomy, and parotidectomy. Otolaryngol Head Neck Surg 124(5):537–543PubMedCrossRef

129.

Marcus B, Edwards B, Yoo S, Byrne A, Gupta A, Kandrevas J, Bradford C, Chepeha DB, Teknos TN (2003) Recurrent laryngeal nerve monitoring in thyroid and parathyroid surgery: the University of Michigan experience. Laryngoscope 113(2):356–361PubMedCrossRef

130.

Snyder SK, Hendricks JC (2005) Intraoperative neurophysiology testing of the recurrent laryngeal nerve: plaudits and pitfalls. Surgery 138(6):1183–1191 discussion 1191–1182PubMedCrossRef

131.

Dralle H, Sekulla C, Haerting J, Timmermann W, Neumann HJ, Kruse E, Grond S, Muhlig HP, Richter C, Voss J, Thomusch O, Lippert H, Gastinger I, Brauckhoff M, Gimm O (2004) Risk factors of paralysis and functional outcome after recurrent laryngeal nerve monitoring in thyroid surgery. Surgery 136(6):1310–1322PubMedCrossRef

132.

Barczynski M, Konturek A, Cichon S (2009) Randomized clinical trial of visualization versus neuromonitoring of recurrent laryngeal nerves during thyroidectomy. Br J Surg 96(3):240–246PubMedCrossRef

133.

Hermann M, Alk G, Roka R, Glaser K, Freissmuth M (2002) Laryngeal recurrent nerve injury in surgery for benign thyroid diseases: effect of nerve dissection and impact of individual surgeon in more than 27, 000 nerves at risk. Ann Surg 235(2):261–268PubMedCrossRef

134.

Jatzko GR, Lisborg PH, Muller MG, Wette VM (1994) Recurrent nerve palsy after thyroid operations—principal nerve identification and a literature review. Surgery 115(2):139–144PubMed

135.

Riddell VH (1956) Injury to recurrent laryngeal nerves during thyroidectomy; a comparison between the results of identification and non-identification in 1022 nerves exposed to risk. Lancet 271(6944):638–641PubMedCrossRef

136.

Randolph G, Urken M (2003) Surgical management of primary hyperparathyroidism. In: Randolph G (ed) Surgery of the thyroid and parathyroid glands. Saunders, Philadelphia, pp 507–528

Titel: Intraoperative adjuncts in surgery for primary hyperparathyroidism
verfasst von: Barney J. Harrison
Frederic Triponez
Publikationsdatum: 01.09.2009
Verlag: Springer-Verlag
Erschienen in: Langenbeck's Archives of Surgery / Ausgabe 5/2009
Print ISSN: 1435-2443
Elektronische ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-009-0532-6

Neu im Fachgebiet Chirurgie

Wie erfolgreich ist eine Re-Ablation nach Rezidiv?

23.04.2024 Ablationstherapie Nachrichten

Nach der Katheterablation von Vorhofflimmern kommt es bei etwa einem Drittel der Patienten zu Rezidiven, meist binnen eines Jahres. Wie sich spätere Rückfälle auf die Erfolgschancen einer erneuten Ablation auswirken, haben Schweizer Kardiologen erforscht.

Hinter dieser Appendizitis steckte ein Erreger

23.04.2024 Appendizitis Nachrichten

Schmerzen im Unterbauch, aber sonst nicht viel, was auf eine Appendizitis hindeutete: Ein junger Mann hatte Glück, dass trotzdem eine Laparoskopie mit Appendektomie durchgeführt und der Wurmfortsatz histologisch untersucht wurde.

Mehr Schaden als Nutzen durch präoperatives Aussetzen von GLP-1-Agonisten?

23.04.2024 Operationsvorbereitung Nachrichten

Derzeit wird empfohlen, eine Therapie mit GLP-1-Rezeptoragonisten präoperativ zu unterbrechen. Eine neue Studie nährt jedoch Zweifel an der Notwendigkeit der Maßnahme.

Ureterstriktur: Innovative OP-Technik bewährt sich

19.04.2024 EAU 2024 Kongressbericht

Die Ureterstriktur ist eine relativ seltene Komplikation, trotzdem bedarf sie einer differenzierten Versorgung. In komplexen Fällen wird dies durch die roboterassistierte OP-Technik gewährleistet. Erste Resultate ermutigen.

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Aktuelle BDC Leitlinien-Webinare

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom BDC Leitlinien Webinare

CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare

CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske

Dr. med. Benjamin Meyknecht

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare

CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric

Springer Medizin

Abstract

Purpose

Materials and methods

Results

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2009

A new anchor electrode design for continuous neuromonitoring of the recurrent laryngeal nerve by vagal nerve stimulations

Utility of intraoperative bilateral internal jugular venous sampling with rapid parathyroid hormone testing in guiding patients with a negative sestamibi scan for minimally invasive parathyroidectomy—a randomized controlled trial

Benefits of surgeon-performed ultrasound for primary hyperparathyroidism

The effectiveness of FloSeal® matrix hemostatic agent in thyroid surgery: a prospective, randomized, control study

Is minimally invasive parathyroidectomy without QPTH monitoring justified?

Imaging for primary hyperparathyroidism—an evidence-based analysis

Update Chirurgie