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01.02.2015 | Musculoskeletal

Intravenous contrast injection significantly affects bone mineral density measured on CT

verfasst von: Esther Pompe, Martin J. Willemink, Gawein R. Dijkhuis, Harald J. J. Verhaar, Firdaus A. A. Mohamed Hoesein, Pim A. de Jong

Erschienen in: European Radiology | Ausgabe 2/2015

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Abstract

Objective

The objective is to evaluate the effect of intravenous contrast media on bone mineral density (BMD) assessment by comparing unenhanced and contrast-enhanced computed tomography (CT) examinations performed for other indications.

Methods

One hundred and fifty-two patients (99 without and 53 with malignant neoplasm) who underwent both unenhanced and two contrast-enhanced (arterial and portal venous phase) abdominal CT examinations in a single session between June 2011 and July 2013 were included. BMD was evaluated on the three examinations as CT-attenuation values in Hounsfield Units (HU) in the first lumbar vertebra (L1).

Results

CT-attenuation values were significantly higher in both contrast-enhanced phases, compared to the unenhanced phase (p < 0.01). In patients without malignancies, mean ± standard deviation (SD) HU-values increased from 128.8 ± 48.6 HU for the unenhanced phase to 142.3 ± 47.2 HU for the arterial phase and 147.0 ± 47.4 HU for the portal phase (p < 0.01). In patients with malignancies, HU-values increased from 112.1 ± 38.1 HU to 126.2 ± 38.4 HU and 130.1 ± 37.3 HU (p < 0.02), respectively. With different thresholds to define osteoporosis, measurements in the arterial and portal phase resulted in 7-25 % false negatives.

Conclusions

Our study showed that intravenous contrast injection substantially affects BMD-assessment on CT and taking this into account may improve routine assessment of low BMD in nonquantitative CT.

Key Points

• Routine CT may gain a role in bone attenuation measurements for osteoporosis

• Contrast media injection has substantial influence on CT-derived bone density

• Contrast-enhanced CT leads to underestimation of osteoporosis compared to unenhanced CT

• Adjusting for contrast injection phase may improve CT screening protocols for osteoporosis.

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Titel: Intravenous contrast injection significantly affects bone mineral density measured on CT
verfasst von: Esther Pompe
Martin J. Willemink
Gawein R. Dijkhuis
Harald J. J. Verhaar
Firdaus A. A. Mohamed Hoesein
Pim A. de Jong
Publikationsdatum: 01.02.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 2/2015
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3408-2

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Intravenous contrast injection significantly affects bone mineral density measured on CT