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Erschienen in: Brain Structure and Function 6/2004

01.09.2004 | Original Article

Intrinsic cartilage-forming potential of dermomyotomal cells requires ectodermal signals for the development of the scapula blade

verfasst von: Florian Ehehalt, Baigang Wang, Bodo Christ, Ketan Patel, Ruijin Huang

Erschienen in: Brain Structure and Function | Ausgabe 6/2004

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Abstract

The avian scapula has a dual origin. The cranial part derives from the somatopleure of the forelimb field, while the caudal part, the scapula blade, originates from the dermomyotomes of the cervicothoracic transition zone. Thus, these dermomyotomes have, in addition to the well-known myogenic, angiogenic, and dermogenic potential, the ability to form cartilage. The scapula blade is therefore a derivative of dermomyotomal chondrogenesis. Although the mechanisms that direct the sclerotomal chondrogenesis are beginning to be understood, little is known about dermomyotomal chondrogenesis. Here, we address the mechanisms that control dermomyotomal cells to become chondrocytes. After heterotopic transplantation of dorsal epithelial somite halves from the scapula-forming level to the cervical level, the grafted tissue retains the capability to form cartilage, indicating that the dermomyotomal chondrogenic potential must be specified during anterior-to-posterior regionalisation of the paraxial mesoderm. Furthermore, we show that signals from the ectoderm are required, allowing dermomyotome cells to express markers associated with the chondrogenic lineage.
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Metadaten
Titel
Intrinsic cartilage-forming potential of dermomyotomal cells requires ectodermal signals for the development of the scapula blade
verfasst von
Florian Ehehalt
Baigang Wang
Bodo Christ
Ketan Patel
Ruijin Huang
Publikationsdatum
01.09.2004
Verlag
Springer-Verlag
Erschienen in
Brain Structure and Function / Ausgabe 6/2004
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-004-0415-0