Skip to main content
Erschienen in: Zeitschrift für Epileptologie 2/2009

01.05.2009 | Originalarbeit

Invasive Hirnstimulationsverfahren in der Epilepsietherapie

verfasst von: C. Stephani, M.A. Nitsche, W. Paulus

Erschienen in: Clinical Epileptology | Ausgabe 2/2009

Einloggen, um Zugang zu erhalten

Zusammenfassung

Epilepsiepatienten, denen weder pharmakologische noch epilepsiechirurgische Therapien helfen oder angeboten werden können, stehen wenige ergänzende therapeutische Verfahren zu Verfügung. Methoden der Hirnstimulation wie die Vagusnervstimulation (VNS) oder die Tiefenhirnstimulation („deep brain stimulation“, DBS) gehören dazu. Angesichts der ungünstigen Prognosen therapierefraktärer oder katastrophaler Epilepsien sind diese Verfahren Gegenstand vielfältiger Forschungsbemühungen. Der folgende Beitrag soll eine Einleitung in Erkenntnisse und Perspektiven invasiver Stimulationsverfahren unter Berücksichtigung der gegenwärtigen klinischen Praxis geben.
Literatur
1.
Zurück zum Zitat Aldenkamp AP, Majoie HJ, Berfelo MW et al (2002) Long-term effects of 24-month treatment with vagus nerve stimulation on behaviour in children with Lennox-Gastaut syndrome. Epilepsy Behav 3(5):475–479CrossRefPubMed Aldenkamp AP, Majoie HJ, Berfelo MW et al (2002) Long-term effects of 24-month treatment with vagus nerve stimulation on behaviour in children with Lennox-Gastaut syndrome. Epilepsy Behav 3(5):475–479CrossRefPubMed
2.
Zurück zum Zitat Annegers JF, Coan SP, Hauser WA, Leestma J (2004) Epilepsy, vagal nerve stimulation by the NCP system, all-cause mortality and sudden, unexpected, unexplained death. Epilepsia 41(5):549–553CrossRef Annegers JF, Coan SP, Hauser WA, Leestma J (2004) Epilepsy, vagal nerve stimulation by the NCP system, all-cause mortality and sudden, unexpected, unexplained death. Epilepsia 41(5):549–553CrossRef
3.
Zurück zum Zitat Bartholow R (1874) Experimental investigations into the functions of the human brain. Am J Med Sci 67:305–313CrossRef Bartholow R (1874) Experimental investigations into the functions of the human brain. Am J Med Sci 67:305–313CrossRef
4.
Zurück zum Zitat Benabid AL, Pollak P, Gervason C et al (1991) Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus. Lancet 16:403–406CrossRef Benabid AL, Pollak P, Gervason C et al (1991) Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus. Lancet 16:403–406CrossRef
5.
Zurück zum Zitat Benabid AL, Minotti L, Koudsie A et al (2002) Antiepileptic effect of high-frequency stimulation of the subthalamic nucleus (corpus Luysi) in a case of medically intractable epilepsy caused by focal dysplasia: a 30-month follow-up: technical case report. Neurosurgery 50:1385–1391CrossRefPubMed Benabid AL, Minotti L, Koudsie A et al (2002) Antiepileptic effect of high-frequency stimulation of the subthalamic nucleus (corpus Luysi) in a case of medically intractable epilepsy caused by focal dysplasia: a 30-month follow-up: technical case report. Neurosurgery 50:1385–1391CrossRefPubMed
6.
Zurück zum Zitat Ben-Menachem E (2002) Vagus-nerve stimulation for the treatment of epilepsy. Lancet Neurol 1:477–482CrossRefPubMed Ben-Menachem E (2002) Vagus-nerve stimulation for the treatment of epilepsy. Lancet Neurol 1:477–482CrossRefPubMed
7.
Zurück zum Zitat Ben-Menachem E, Manon-Espaillat R, Ristanovic R et al (1994) Vagus nerve stimulation for treatment of partial seizures: 1. A controlled study of effect on seizures. Epilepsia 35(3):616–626CrossRefPubMed Ben-Menachem E, Manon-Espaillat R, Ristanovic R et al (1994) Vagus nerve stimulation for treatment of partial seizures: 1. A controlled study of effect on seizures. Epilepsia 35(3):616–626CrossRefPubMed
8.
Zurück zum Zitat Berney A, Vingerhoets F, Perrin A et al (2002) Effect on mood of subthalamic DBS for Parkinson’s disease: a consecutive series of 24 patients. Neurology 59:1427–1429PubMed Berney A, Vingerhoets F, Perrin A et al (2002) Effect on mood of subthalamic DBS for Parkinson’s disease: a consecutive series of 24 patients. Neurology 59:1427–1429PubMed
9.
Zurück zum Zitat Bingaman WE (2008) Vagal nerve stimulation: surgical technique and complications. In: Lüders HO (ed) Textbook of epilepsy surgery. Informa Healthcare, London, pp 1184–1187 Bingaman WE (2008) Vagal nerve stimulation: surgical technique and complications. In: Lüders HO (ed) Textbook of epilepsy surgery. Informa Healthcare, London, pp 1184–1187
10.
Zurück zum Zitat Blumenfeld H, McCormick DA (2000) Corticothalamic inputs control the pattern of activity generated in thalamocortical networks. J Neurosci 20:5153–5162PubMed Blumenfeld H, McCormick DA (2000) Corticothalamic inputs control the pattern of activity generated in thalamocortical networks. J Neurosci 20:5153–5162PubMed
11.
Zurück zum Zitat Boon P, Vonck K, De Herdt V et al (2007) Deep brain stimulation in patients with refractory temporal lobe epilepsy. Epilepsia 48(8):1551–1560CrossRefPubMed Boon P, Vonck K, De Herdt V et al (2007) Deep brain stimulation in patients with refractory temporal lobe epilepsy. Epilepsia 48(8):1551–1560CrossRefPubMed
12.
Zurück zum Zitat Catenoix H, Mauguière F, Guénot M et al (2008) SEEG-guided thermocoagulations – a palliative treatment of nonoperable partial epilepsies. Neurology 71:1719–1726CrossRefPubMed Catenoix H, Mauguière F, Guénot M et al (2008) SEEG-guided thermocoagulations – a palliative treatment of nonoperable partial epilepsies. Neurology 71:1719–1726CrossRefPubMed
13.
Zurück zum Zitat Chase MH, Nakamura Y (1968) Cortical and subcortical EEG patterns of response to afferent abdominal vagal stimulation: neurographic correlates. Physiol Behav 3:605–610CrossRef Chase MH, Nakamura Y (1968) Cortical and subcortical EEG patterns of response to afferent abdominal vagal stimulation: neurographic correlates. Physiol Behav 3:605–610CrossRef
14.
Zurück zum Zitat Cooper IS (1973) Effect of chronic stimulation of anterior cerebellum on neurological disease. Lancet 1(7796):206CrossRefPubMed Cooper IS (1973) Effect of chronic stimulation of anterior cerebellum on neurological disease. Lancet 1(7796):206CrossRefPubMed
15.
Zurück zum Zitat Cooper IS, Amin I, Riklan M et al (1976) Chronic cerebellar stimulation in epilepsy. Clinical and anatomical studies. Arch Neurol 33(8):559–570PubMed Cooper IS, Amin I, Riklan M et al (1976) Chronic cerebellar stimulation in epilepsy. Clinical and anatomical studies. Arch Neurol 33(8):559–570PubMed
16.
Zurück zum Zitat Dedeurwaerdere S, Vonck K et al (2004) Acute vagus nerve stimulation does not suppress spike and wave discharges in genetic absence epilepsy rats from Strasbourg. Epilepsy Res 59:191–198CrossRefPubMed Dedeurwaerdere S, Vonck K et al (2004) Acute vagus nerve stimulation does not suppress spike and wave discharges in genetic absence epilepsy rats from Strasbourg. Epilepsy Res 59:191–198CrossRefPubMed
17.
Zurück zum Zitat DeGiorgio CM, Shewmon A, Murray D, Whitehurst T (2006) Pilot study of trigeminal nerve stimulation (TNS) for epilepsy: a proof-of-concept trial. Epilepsia 47(7):1213–1215CrossRefPubMed DeGiorgio CM, Shewmon A, Murray D, Whitehurst T (2006) Pilot study of trigeminal nerve stimulation (TNS) for epilepsy: a proof-of-concept trial. Epilepsia 47(7):1213–1215CrossRefPubMed
18.
Zurück zum Zitat Deransart C, Depaulis A (2008) Experimental evidence for the involvement of the basal ganglia in the control of epilepsy. In: Lüders HO (ed) Textbook of epilepsy surgery. Informa Healthcare, London, pp 1201–1207 Deransart C, Depaulis A (2008) Experimental evidence for the involvement of the basal ganglia in the control of epilepsy. In: Lüders HO (ed) Textbook of epilepsy surgery. Informa Healthcare, London, pp 1201–1207
19.
Zurück zum Zitat Diederich NJ, Alesch F, Goetz C (2000) Visual hallucinations induced by deep brain stimulation in Parkinson’s disease. Clin Neuropharmacol 23:287–289CrossRefPubMed Diederich NJ, Alesch F, Goetz C (2000) Visual hallucinations induced by deep brain stimulation in Parkinson’s disease. Clin Neuropharmacol 23:287–289CrossRefPubMed
20.
Zurück zum Zitat Dorr AE, Debonnel G (2006) Effect of vagus nerve stimulation on serotonergic and noradrenergic transmission. J Pharmacol Exp Ther 318:890–898CrossRefPubMed Dorr AE, Debonnel G (2006) Effect of vagus nerve stimulation on serotonergic and noradrenergic transmission. J Pharmacol Exp Ther 318:890–898CrossRefPubMed
21.
Zurück zum Zitat Fanselow EE, Reid AP, Nicolelis MAL (2000) Reduction of pentylenetetrazole-induced seizure activity in awake rats by seizure-triggered trigeminal nerve stimulation. J Neurosci 20(21):8160–8168PubMed Fanselow EE, Reid AP, Nicolelis MAL (2000) Reduction of pentylenetetrazole-induced seizure activity in awake rats by seizure-triggered trigeminal nerve stimulation. J Neurosci 20(21):8160–8168PubMed
22.
Zurück zum Zitat Fisher RS, Uematsu S, Krauss G et al (1992) Placebo-controlled pilot study of centromedian thalamic stimulation in treatment of intractable seizures. Epilepsia 33:841–851CrossRefPubMed Fisher RS, Uematsu S, Krauss G et al (1992) Placebo-controlled pilot study of centromedian thalamic stimulation in treatment of intractable seizures. Epilepsia 33:841–851CrossRefPubMed
23.
Zurück zum Zitat Flanigin HF (1989) Depth electrode studies in pre-surgical evaluations (abstract). Electromyogr Clin Neurophysiol 73:67P Flanigin HF (1989) Depth electrode studies in pre-surgical evaluations (abstract). Electromyogr Clin Neurophysiol 73:67P
24.
Zurück zum Zitat Foley JO, DuBois F (1937) Quantitative studies of the vagus nerve in the cat. I. The ratio of sensory to motor fibers. J Comp Neurol 67:49–67CrossRef Foley JO, DuBois F (1937) Quantitative studies of the vagus nerve in the cat. I. The ratio of sensory to motor fibers. J Comp Neurol 67:49–67CrossRef
25.
Zurück zum Zitat Fountas KN, Smith JR, Murro AM et al (2005) Implantation of a closed-loop stimulation in the management of medically refractory focal epilepsy: a technical note. Stereotact Funct Neurosurg 83(4):153–158CrossRefPubMed Fountas KN, Smith JR, Murro AM et al (2005) Implantation of a closed-loop stimulation in the management of medically refractory focal epilepsy: a technical note. Stereotact Funct Neurosurg 83(4):153–158CrossRefPubMed
26.
Zurück zum Zitat Franzini A, Ferroli P, Leone M, Broggi G (2003) Stimulation of the posterior hypothalamus for treatment of chronic intractable cluster headaches: first reported series. Neurosurgery 52(5):1095–1099CrossRefPubMed Franzini A, Ferroli P, Leone M, Broggi G (2003) Stimulation of the posterior hypothalamus for treatment of chronic intractable cluster headaches: first reported series. Neurosurgery 52(5):1095–1099CrossRefPubMed
27.
Zurück zum Zitat Fritsch G, Hitzig E (1870) Über die elektrische Erregbarkeit des Großhirnes. Arch Anat Physiol Wiss Med 37:300–332 Fritsch G, Hitzig E (1870) Über die elektrische Erregbarkeit des Großhirnes. Arch Anat Physiol Wiss Med 37:300–332
28.
Zurück zum Zitat Gaitatzis A, Johnson AL, Chadwick DW et al (2004) Life expectancy in people with newly diagnosed epilepsy. Brain 127:2427–2432CrossRefPubMed Gaitatzis A, Johnson AL, Chadwick DW et al (2004) Life expectancy in people with newly diagnosed epilepsy. Brain 127:2427–2432CrossRefPubMed
29.
Zurück zum Zitat Hallbook T, Lundgren J, Blennow G et al (2005) Long term effects on epileptiform activity with vagus nerve stimulation in children. Seizure 14(8):527–533CrossRefPubMed Hallbook T, Lundgren J, Blennow G et al (2005) Long term effects on epileptiform activity with vagus nerve stimulation in children. Seizure 14(8):527–533CrossRefPubMed
30.
Zurück zum Zitat Hamani C, Hodaie M, Lozano AM (2005) Present and future of deep brain stimulation for refractory epilepsy. Acta Neurochir 147:227–229CrossRef Hamani C, Hodaie M, Lozano AM (2005) Present and future of deep brain stimulation for refractory epilepsy. Acta Neurochir 147:227–229CrossRef
31.
Zurück zum Zitat Hammond EJ, Uthman BM, Reid SA, Wilder BJ (1992) Electrophysiological studies of cervical vagus nerve stimulation in humans: 1. EEG effects. Epilepsia 33(6):1013–1020CrossRefPubMed Hammond EJ, Uthman BM, Reid SA, Wilder BJ (1992) Electrophysiological studies of cervical vagus nerve stimulation in humans: 1. EEG effects. Epilepsia 33(6):1013–1020CrossRefPubMed
32.
Zurück zum Zitat Handforth A, De Giorgio CM, Schachter SC et al (1998) Vagus nerve stimulation therapy for partial-onset seizures: a randomized active control trial. Neurology 51(1):48–55PubMed Handforth A, De Giorgio CM, Schachter SC et al (1998) Vagus nerve stimulation therapy for partial-onset seizures: a randomized active control trial. Neurology 51(1):48–55PubMed
33.
Zurück zum Zitat Herzog R, Voges J, Ghaemi M et al (2003) Deep brain stimulation of the subthalamic nucleus does not increase the striatal dopamine concentration in parkinsonian humans. Mov Disord 18:41–48CrossRef Herzog R, Voges J, Ghaemi M et al (2003) Deep brain stimulation of the subthalamic nucleus does not increase the striatal dopamine concentration in parkinsonian humans. Mov Disord 18:41–48CrossRef
34.
Zurück zum Zitat Hodaie M, Wennberg RA, Dostrovsky JO, Lozano AM (2002) Chronic anterior thalamus stimulation for intractable epilepsy. Epilepsia 43(6):603–608CrossRefPubMed Hodaie M, Wennberg RA, Dostrovsky JO, Lozano AM (2002) Chronic anterior thalamus stimulation for intractable epilepsy. Epilepsia 43(6):603–608CrossRefPubMed
35.
Zurück zum Zitat Houeto JL, Karachi C, Mallet L (2005) Tourette’s syndrome and deep brain stimulation. J Neurol Neurosurg Psychiatry 76(7):992–995CrossRefPubMed Houeto JL, Karachi C, Mallet L (2005) Tourette’s syndrome and deep brain stimulation. J Neurol Neurosurg Psychiatry 76(7):992–995CrossRefPubMed
36.
Zurück zum Zitat Jensen AL, Durand DM (2007) Suppression of axonal conduction by sinusoidal stimulation in rat hippocampus in vitro. J Neural Eng 4:1–16CrossRefPubMed Jensen AL, Durand DM (2007) Suppression of axonal conduction by sinusoidal stimulation in rat hippocampus in vitro. J Neural Eng 4:1–16CrossRefPubMed
37.
Zurück zum Zitat Kellinghaus C, Loddenkemper T, Möddel G et al (2003) Elektrische Hirnstimulation in der Epilepsietherapie. Nervenarzt 74:664–676CrossRefPubMed Kellinghaus C, Loddenkemper T, Möddel G et al (2003) Elektrische Hirnstimulation in der Epilepsietherapie. Nervenarzt 74:664–676CrossRefPubMed
38.
39.
Zurück zum Zitat Kringelbach ML, Jenkinson N, Owen SLF, Aziz TZ (2007) Translational principles of deep brain stimulation. Nat Rev Neurosci 8(8):623–635CrossRefPubMed Kringelbach ML, Jenkinson N, Owen SLF, Aziz TZ (2007) Translational principles of deep brain stimulation. Nat Rev Neurosci 8(8):623–635CrossRefPubMed
40.
Zurück zum Zitat Kuba R, Guzaninova M, Brazdil M et al (2002) Effect of vagal nerve stimulation on interictal epileptiform discharges: a scalp EEG study. Epilepsia 43(10):1181–1188CrossRefPubMed Kuba R, Guzaninova M, Brazdil M et al (2002) Effect of vagal nerve stimulation on interictal epileptiform discharges: a scalp EEG study. Epilepsia 43(10):1181–1188CrossRefPubMed
41.
Zurück zum Zitat Kupsch A, Benecke R, Müller J et al (2006) Pallidal deep-brain stimulation in primary generalized or segmental dystonia. N Engl J Med 355:1978–1990CrossRefPubMed Kupsch A, Benecke R, Müller J et al (2006) Pallidal deep-brain stimulation in primary generalized or segmental dystonia. N Engl J Med 355:1978–1990CrossRefPubMed
42.
Zurück zum Zitat Lee GP, Bechara A, Adolphs R et al (1997) Clinical and physiological effects of stereotaxic bilateral amygdalotomy for intractable aggression. J Neuropsychiatry 10:413–420 Lee GP, Bechara A, Adolphs R et al (1997) Clinical and physiological effects of stereotaxic bilateral amygdalotomy for intractable aggression. J Neuropsychiatry 10:413–420
43.
Zurück zum Zitat Lefaucheur J-P (2008) Principles of therapeutic use of transcranial and epidural cortical stimulation. Clin Neurophysiol 119:2179–2184CrossRefPubMed Lefaucheur J-P (2008) Principles of therapeutic use of transcranial and epidural cortical stimulation. Clin Neurophysiol 119:2179–2184CrossRefPubMed
44.
Zurück zum Zitat Lesser RP, Kim SH, Beyderman L et al (1999) Brief bursts of pulse stimulation terminate afterdischarges caused by cortical stimulation. Neurology 53:2073–2081PubMed Lesser RP, Kim SH, Beyderman L et al (1999) Brief bursts of pulse stimulation terminate afterdischarges caused by cortical stimulation. Neurology 53:2073–2081PubMed
45.
Zurück zum Zitat Lockard JS, Congdon WC, DuCharme LL (1990) Feasibility and safety of vagal stimulation in monkey model. Epilepsia 31 [Suppl 2]:S20–S26 Lockard JS, Congdon WC, DuCharme LL (1990) Feasibility and safety of vagal stimulation in monkey model. Epilepsia 31 [Suppl 2]:S20–S26
46.
Zurück zum Zitat Loddenkemper T, Pan A, Neme S et al (2001) Deep brain stimulation in epilepsy. J Clin Neurophysiol 18(6):514–532CrossRefPubMed Loddenkemper T, Pan A, Neme S et al (2001) Deep brain stimulation in epilepsy. J Clin Neurophysiol 18(6):514–532CrossRefPubMed
47.
Zurück zum Zitat Mayberg HS, Lozano AM, Voon V et al (2005) Deep brain stimulation for treatment-resistant depression. Neuron 45:651–660CrossRefPubMed Mayberg HS, Lozano AM, Voon V et al (2005) Deep brain stimulation for treatment-resistant depression. Neuron 45:651–660CrossRefPubMed
48.
Zurück zum Zitat Morrell M (2006) Brain stimulation for epilepsy: can scheduled or responsive neurostimulation stop seizures? Curr Opin Neurol 19:164–168CrossRefPubMed Morrell M (2006) Brain stimulation for epilepsy: can scheduled or responsive neurostimulation stop seizures? Curr Opin Neurol 19:164–168CrossRefPubMed
49.
Zurück zum Zitat Morris GL 3rd, Mueller WM (1999) Long-term treatment with vagus nerve stimulation in patients with refractory epilepsy. The Vagus Nerve Stimulation Study Group E01-E05. Neurology 53(8):1731–1735PubMed Morris GL 3rd, Mueller WM (1999) Long-term treatment with vagus nerve stimulation in patients with refractory epilepsy. The Vagus Nerve Stimulation Study Group E01-E05. Neurology 53(8):1731–1735PubMed
50.
Zurück zum Zitat Narabayashi H, Nagao T, Saito Y et al (1963) Stereotaxic amygdalotomy for behavior disorders. Arch Neurol 9:1–16PubMed Narabayashi H, Nagao T, Saito Y et al (1963) Stereotaxic amygdalotomy for behavior disorders. Arch Neurol 9:1–16PubMed
51.
Zurück zum Zitat Nowak LG, Bullier J (1998) Axons, but not cell bodies are activated by electrical stimulation in cortical gray matter. Exp Brain Res 118:477–488CrossRefPubMed Nowak LG, Bullier J (1998) Axons, but not cell bodies are activated by electrical stimulation in cortical gray matter. Exp Brain Res 118:477–488CrossRefPubMed
52.
Zurück zum Zitat Parain D, Penniello MJ, Berquen P et al (2001) Vagal nerve stimulation in tuberous sclerosis complex patients. Pediatr Neurol 25(3):213–216CrossRefPubMed Parain D, Penniello MJ, Berquen P et al (2001) Vagal nerve stimulation in tuberous sclerosis complex patients. Pediatr Neurol 25(3):213–216CrossRefPubMed
53.
Zurück zum Zitat Parent A, Hazrati LN (1995) Functional anatomy of the basal ganglia. II. The place of subthalamic nucleus and external pallidum in basal ganglia circuitry. Brain Res Rev 20:128–154CrossRefPubMed Parent A, Hazrati LN (1995) Functional anatomy of the basal ganglia. II. The place of subthalamic nucleus and external pallidum in basal ganglia circuitry. Brain Res Rev 20:128–154CrossRefPubMed
54.
Zurück zum Zitat Patwardhan RV, Stong B, Bebin EM et al (2000) Efficacy of vagal nerve stimulation in children with medically refractory epilepsy. Neurosurgery 47(6):1353–1357CrossRefPubMed Patwardhan RV, Stong B, Bebin EM et al (2000) Efficacy of vagal nerve stimulation in children with medically refractory epilepsy. Neurosurgery 47(6):1353–1357CrossRefPubMed
55.
Zurück zum Zitat Penalozarojas JH (1964) Electroencephalographic synchronization resulting from direct current application to the vagus nerve. Exp Neurol 9:367–371CrossRefPubMed Penalozarojas JH (1964) Electroencephalographic synchronization resulting from direct current application to the vagus nerve. Exp Neurol 9:367–371CrossRefPubMed
56.
57.
Zurück zum Zitat Penry JK, Dean JC (1990) Prevention of intractable partial seizures by intermittent vagal stimulation in humans: preliminary results. Epilepsia 31 [Suppl 2]:S40–S43 Penry JK, Dean JC (1990) Prevention of intractable partial seizures by intermittent vagal stimulation in humans: preliminary results. Epilepsia 31 [Suppl 2]:S40–S43
58.
Zurück zum Zitat Pilitsis JG, Chu Y, Kordower J et al (2008) Postmortem study of deep brain stimulation of the anterior thalamus: case report. Neurosurgery 62:530–532CrossRef Pilitsis JG, Chu Y, Kordower J et al (2008) Postmortem study of deep brain stimulation of the anterior thalamus: case report. Neurosurgery 62:530–532CrossRef
59.
Zurück zum Zitat Ranck JBJ (1975) Which elements are excited in electrical stimulation of mammalian central nervous system: a review. Brain Res 98:417–440CrossRefPubMed Ranck JBJ (1975) Which elements are excited in electrical stimulation of mammalian central nervous system: a review. Brain Res 98:417–440CrossRefPubMed
60.
Zurück zum Zitat Rouzaire-Dubois B, Scarnati E (1987) Pharmacological study of the cortical-induced excitation of subthalamic nucleus neurons in the rat: evidence for amino acids as putative neurotransmitters. Neuroscience 21:429–440CrossRefPubMed Rouzaire-Dubois B, Scarnati E (1987) Pharmacological study of the cortical-induced excitation of subthalamic nucleus neurons in the rat: evidence for amino acids as putative neurotransmitters. Neuroscience 21:429–440CrossRefPubMed
61.
Zurück zum Zitat Rutecki P (1990) Anatomical, physiological and theoretical basis for the antiepileptic effect of vagus nerve stimulation. Epilepsia 31 [Suppl 2]:S1–S6 Rutecki P (1990) Anatomical, physiological and theoretical basis for the antiepileptic effect of vagus nerve stimulation. Epilepsia 31 [Suppl 2]:S1–S6
62.
Zurück zum Zitat Salinsky MC, Burchiel KJ (1993) Vagus nerve stimulation has no effect on awake EEG rhythms in humans. Epilepsia 34(2):299–304CrossRefPubMed Salinsky MC, Burchiel KJ (1993) Vagus nerve stimulation has no effect on awake EEG rhythms in humans. Epilepsia 34(2):299–304CrossRefPubMed
63.
Zurück zum Zitat Schüle SU, McIntyre C, Lüders HO (2008) General principles of cortical mapping by electrical stimulation. In: Lüders HO (ed) Textbook of epilepsy surgery. Informa Healthcare, London, pp 963–977 Schüle SU, McIntyre C, Lüders HO (2008) General principles of cortical mapping by electrical stimulation. In: Lüders HO (ed) Textbook of epilepsy surgery. Informa Healthcare, London, pp 963–977
64.
Zurück zum Zitat Spanaki MV, Allen LS, Mueller WM et al (2004) Vagus nerve stimulation therapy: 5-year or greater outcome at a university-based epilepsy center. Seizure 13(8):587–590CrossRefPubMed Spanaki MV, Allen LS, Mueller WM et al (2004) Vagus nerve stimulation therapy: 5-year or greater outcome at a university-based epilepsy center. Seizure 13(8):587–590CrossRefPubMed
65.
Zurück zum Zitat Stoica I, Tudor I (1968) Vagal trunk stimulation influences on epileptic spiking focus activity. Rev Roum Neurol 5:203–210 Stoica I, Tudor I (1968) Vagal trunk stimulation influences on epileptic spiking focus activity. Rev Roum Neurol 5:203–210
66.
Zurück zum Zitat Van Buren JM, Wood JH, Oakley J, Hambrecht F (1978) Preliminary evaluation of cerebellar stimulation by double-blind stimulation and biological criteria in the treatment of epilepsy. J Neurosurg 48(3):407–416CrossRef Van Buren JM, Wood JH, Oakley J, Hambrecht F (1978) Preliminary evaluation of cerebellar stimulation by double-blind stimulation and biological criteria in the treatment of epilepsy. J Neurosurg 48(3):407–416CrossRef
67.
Zurück zum Zitat Velasco F, Velasco M, Ogarrio C, Fanghanel G (1987) Electrical stimulation of the centromedian thalamic nucleus in the treatment of convulsive seizures: a preliminary report. Epilepsia 28:421–430CrossRefPubMed Velasco F, Velasco M, Ogarrio C, Fanghanel G (1987) Electrical stimulation of the centromedian thalamic nucleus in the treatment of convulsive seizures: a preliminary report. Epilepsia 28:421–430CrossRefPubMed
68.
Zurück zum Zitat Velasco F, Velasco M, Velasco AL et al (1995) Electrical stimulation of the centromedian thalamic nucleus in control of seizures: long-term studies. Epilepsia 36:63–71CrossRefPubMed Velasco F, Velasco M, Velasco AL et al (1995) Electrical stimulation of the centromedian thalamic nucleus in control of seizures: long-term studies. Epilepsia 36:63–71CrossRefPubMed
69.
Zurück zum Zitat Velasco M, Velasco F, Velasco AL et al (2000) Subacute electrical stimulation of the hippocampus blocks intractable temporal lobe seizures and paroxysmal EEG activities. Epilepsia 41(2):158–169CrossRefPubMed Velasco M, Velasco F, Velasco AL et al (2000) Subacute electrical stimulation of the hippocampus blocks intractable temporal lobe seizures and paroxysmal EEG activities. Epilepsia 41(2):158–169CrossRefPubMed
70.
Zurück zum Zitat Vidailhet M, Vercueil L, Houeto JL et al (2005) Bilateral deep-brain stimulation of the globus pallidus in primary generalized dystonia. N Engl J Med 352(5):498–500CrossRef Vidailhet M, Vercueil L, Houeto JL et al (2005) Bilateral deep-brain stimulation of the globus pallidus in primary generalized dystonia. N Engl J Med 352(5):498–500CrossRef
71.
Zurück zum Zitat Vonck K, Boon P, Achten E et al (2002) Long-term amygdalohippocampal stimulation for refractory temporal lobe epilepsy. Ann Neurol 52(5):556–565CrossRefPubMed Vonck K, Boon P, Achten E et al (2002) Long-term amygdalohippocampal stimulation for refractory temporal lobe epilepsy. Ann Neurol 52(5):556–565CrossRefPubMed
72.
Zurück zum Zitat Weiss G (1901) Sur la possibilité de rendre comparable entre eux les appareils servant a l’excitation électrique. Arch Ital Biol 35:413–446 Weiss G (1901) Sur la possibilité de rendre comparable entre eux les appareils servant a l’excitation électrique. Arch Ital Biol 35:413–446
73.
Zurück zum Zitat Woodbury DM, Woodbury JW (1990) Effects of vagal stimulation on experimentally induced seizures in rats. Epilepsia 31 [Suppl 2]:S7–S19 Woodbury DM, Woodbury JW (1990) Effects of vagal stimulation on experimentally induced seizures in rats. Epilepsia 31 [Suppl 2]:S7–S19
74.
Zurück zum Zitat Wright GD, McLellan DL, Brice JG (1984) A double-blind trial of chronic cerebellar stimulation in twelve patients with severe epilepsy. J Neurol Neurosurg Psychiatry 47(8):769–774CrossRefPubMed Wright GD, McLellan DL, Brice JG (1984) A double-blind trial of chronic cerebellar stimulation in twelve patients with severe epilepsy. J Neurol Neurosurg Psychiatry 47(8):769–774CrossRefPubMed
75.
Zurück zum Zitat Zabara J (1992) Inhibition of experimental seizures in canines by repetitive vagal stimulation. Epilepsia 33(6):1005–1012CrossRefPubMed Zabara J (1992) Inhibition of experimental seizures in canines by repetitive vagal stimulation. Epilepsia 33(6):1005–1012CrossRefPubMed
76.
Zurück zum Zitat Zanchetti A, Wang SC, Moruzzi G (1952) The effect of vagal afferent stimulation on the EEG pattern of the cat. Electromyogr Clin Neurophysiol 4:357–361CrossRef Zanchetti A, Wang SC, Moruzzi G (1952) The effect of vagal afferent stimulation on the EEG pattern of the cat. Electromyogr Clin Neurophysiol 4:357–361CrossRef
77.
Zurück zum Zitat Zhu-Ge ZB, Zhu Y-Y, Wu D-C et al (2007) Unilateral low-frequent stimulation of central piriform cortex inhibits amygdaloid-kindled seizures in Sprague-Dawley rats. Neuroscience 146(3):901–906CrossRefPubMed Zhu-Ge ZB, Zhu Y-Y, Wu D-C et al (2007) Unilateral low-frequent stimulation of central piriform cortex inhibits amygdaloid-kindled seizures in Sprague-Dawley rats. Neuroscience 146(3):901–906CrossRefPubMed
78.
Zurück zum Zitat Zumsteg D, Lozano AM, Wieser HG, Wennberg RA (2006) Cortical activation with deep brain stimulation of the anterior thalamus for epilepsy. Clin Neurophysiol 117:192–207CrossRefPubMed Zumsteg D, Lozano AM, Wieser HG, Wennberg RA (2006) Cortical activation with deep brain stimulation of the anterior thalamus for epilepsy. Clin Neurophysiol 117:192–207CrossRefPubMed
Metadaten
Titel
Invasive Hirnstimulationsverfahren in der Epilepsietherapie
verfasst von
C. Stephani
M.A. Nitsche
W. Paulus
Publikationsdatum
01.05.2009
Verlag
D. Steinkopff-Verlag
Erschienen in
Clinical Epileptology / Ausgabe 2/2009
Print ISSN: 2948-104X
Elektronische ISSN: 2948-1058
DOI
https://doi.org/10.1007/s10309-009-0029-x

Weitere Artikel der Ausgabe 2/2009

Zeitschrift für Epileptologie 2/2009 Zur Ausgabe

Mitteilungen der Stiftung Michael

Mitteilungen der Stiftung Michael

Mitteilungen der Deutschen Gesellschaft für Epileptologie

Mitteilungen der Deutschen Gesellschaft für Epileptologie e.V.

Mitteilungen der Arbeitsgemeinschaft für prächirurgische Epilepsiediagnostik und operative Epilepsietherapie

Mitteilungen der Arbeitsgemeinschaft für prächirurgische Epilepsiediagnostik und operative Epilepsietherapie

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

17.05.2024 Direkte orale Antikoagulanzien Nachrichten

Kommt es zu einer nichttraumatischen Hirnblutung, spielt es keine große Rolle, ob die Betroffenen zuvor direkt wirksame orale Antikoagulanzien oder Marcumar bekommen haben: Die Prognose ist ähnlich schlecht.

Thrombektomie auch bei großen Infarkten von Vorteil

16.05.2024 Ischämischer Schlaganfall Nachrichten

Auch ein sehr ausgedehnter ischämischer Schlaganfall scheint an sich kein Grund zu sein, von einer mechanischen Thrombektomie abzusehen. Dafür spricht die LASTE-Studie, an der Patienten und Patientinnen mit einem ASPECTS von maximal 5 beteiligt waren.

Schwindelursache: Massagepistole lässt Otholiten tanzen

14.05.2024 Benigner Lagerungsschwindel Nachrichten

Wenn jüngere Menschen über ständig rezidivierenden Lagerungsschwindel klagen, könnte eine Massagepistole der Auslöser sein. In JAMA Otolaryngology warnt ein Team vor der Anwendung hochpotenter Geräte im Bereich des Nackens.

Schützt Olivenöl vor dem Tod durch Demenz?

10.05.2024 Morbus Alzheimer Nachrichten

Konsumieren Menschen täglich 7 Gramm Olivenöl, ist ihr Risiko, an einer Demenz zu sterben, um mehr als ein Viertel reduziert – und dies weitgehend unabhängig von ihrer sonstigen Ernährung. Dafür sprechen Auswertungen zweier großer US-Studien.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.