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Canadian Journal of Anesthesia/Journal canadien d'anesthésie

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24.09.2021 | Review Article/Brief Review

Iron supplementation for patients undergoing cardiac surgery: a systematic review and meta-analysis of randomized controlled trials

verfasst von: Stephen Su Yang, MDCM, MSc, Latifa Al Kharusi, MD, Adam Gosselin, MDCM, Anissa Chirico, MDCM, Pouya Gholipour Baradari, MDCM, Matthew J. Cameron, MDCM, MPH

Erschienen in: Canadian Journal of Anesthesia/Journal canadien d'anesthésie | Ausgabe 1/2022

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Abstract

Purpose

Iron supplementation has been evaluated in several randomized controlled trials (RCTs) for its potential to increase baseline hemoglobin and decrease red blood cell transfusion during cardiac surgery. This study’s main objective was to evaluate the current evidence for iron administration in cardiac surgery patients.

Methods

We searched MEDLINE, EMBASE, CENTRAL, Web of Science databases, and Google Scholar from inception to 19 November 2020 for RCTs evaluating perioperative iron administration in adult patients undergoing cardiac surgery. The RCTs were assessed using a risk of bias assessment and the quality of evidence was assessed using the grading of recommendations, assessments, development, and evaluations.

Results

We reviewed 1,767 citations, and five studies (n = 554) met the inclusion criteria. The use of iron showed no statistical difference in incidence of transfusion (risk ratio, 0.86; 95% confidence interval, 0.65 to 1.13). Trial sequential analysis suggested an optimal information size of 1,132 participants, which the accrued information size did not reach.

Conclusion

The current literature does not support or refute the routine use of iron therapy in cardiac surgery patients.

Trial registration

PROSPERO (CRD42020161927); registered 19 December 2019.

Nur mit Berechtigung zugänglich

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Titel: Iron supplementation for patients undergoing cardiac surgery: a systematic review and meta-analysis of randomized controlled trials
verfasst von: Stephen Su Yang, MDCM, MSc
Latifa Al Kharusi, MD
Adam Gosselin, MDCM
Anissa Chirico, MDCM
Pouya Gholipour Baradari, MDCM
Matthew J. Cameron, MDCM, MPH
Publikationsdatum: 24.09.2021
Verlag: Springer International Publishing
Erschienen in: Canadian Journal of Anesthesia/Journal canadien d'anesthésie / Ausgabe 1/2022
Print ISSN: 0832-610X
Elektronische ISSN: 1496-8975
DOI: https://doi.org/10.1007/s12630-021-02113-z

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Iron supplementation for patients undergoing cardiac surgery: a systematic review and meta-analysis of randomized controlled trials