nach oben

Journal of Bone and Mineral Metabolism

Erschienen in:

08.11.2022 | Original Article

Is Helicobacter pylori infection associated with osteoporosis? a systematic review and meta-analysis

verfasst von: Chuang Xiong, Runhan Zhao, Jingtao Xu, Hao Liang, Jun Zhang, Yanran Huang, Xiaoji Luo

Erschienen in: Journal of Bone and Mineral Metabolism | Ausgabe 1/2023

Einloggen, um Zugang zu erhalten

Abstract

Introduction

This study used systematic review and meta-analysis to evaluate the association between Helicobacter pylori infection and osteoporosis.

Materials and methods

PubMed, Ovid and Web of Science were searched to include observational studies published in English comparing bone mineral density changes between Helicobacter pylori-positive and -negative participants. The quality of the included literature was assessed using the Newcastle–Ottawa Quality Assessment Scale (NOS). R software was used for meta-analysis, and odds ratio (OR) and 95% confidence interval (CI) were calculated to evaluate the relationship between Helicobacter pylori infection and osteoporosis.

Results

Twenty-two studies involving 24,176 participants were included in the study. Our meta-analysis showed that Helicobacter pylori infection was significantly associated with the risk of osteoporosis (OR: 1.12, 95%CI: 1.03, 1.22). Participants infected with the CagA-positive Helicobacter pylori strain were more likely to develop osteoporosis (OR = 1.42, 95%CI: 1.09; 1.85).

Conclusion

Infection with Helicobacter pylori, particularly the CagA-positive strain, has been associated with an increased risk of osteoporosis. The bone health of Helicobacter pylori-positive patients deserves more attention.

Compston JE, McClung MR, Leslie WD (2019) Osteoporosis (in eng). Lancet 393:364–376. https://doi.org/10.1016/s0140-6736(18)32112-3CrossRef

Lane NE (2006) Epidemiology, etiology, and diagnosis of osteoporosis (in eng). Am J Obstet Gynecol 194:S3-11. https://doi.org/10.1016/j.ajog.2005.08.047CrossRef

Shen Y, Huang X, Wu J, Lin X, Zhou X, Zhu Z, Pan X, Xu J, Qiao J, Zhang T, Ye L, Jiang H, Ren Y, Shan PF (2022) The global burden of osteoporosis, low bone mass, and its related fracture in 204 countries and territories, 1990–2019 (in eng). Front Endocrinol (Lausanne) 13:882241. https://doi.org/10.3389/fendo.2022.882241CrossRef

Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures (in eng). Lancet 359:1761–1767. https://doi.org/10.1016/s0140-6736(02)08657-9CrossRef

Hooi JKY, Lai WY, Ng WK, Suen MMY, Underwood FE, Tanyingoh D, Malfertheiner P, Graham DY, Wong VWS, Wu JCY, Chan FKL, Sung JJY, Kaplan GG, Ng SC (2017) Global prevalence of helicobacter pylori infection: systematic review and meta-analysis (in eng). Gastroenterology 153:420–429. https://doi.org/10.1053/j.gastro.2017.04.022CrossRef

Tsay FW, Hsu PI (2018) pylori infection and extra-gastroduodenal diseases (in eng). J Biomed Sci. https://doi.org/10.1186/s12929-018-0469-6CrossRef

Robinson K, Atherton JC (2021) The spectrum of helicobacter-mediated diseases (in eng). Annu Rev Pathol 16:123–144. https://doi.org/10.1146/annurev-pathol-032520-024949CrossRef

Papamichael K, Papaioannou G, Cheifetz MA, Cheifetz AS (2019) Bone of contention: helicobacter pylori and osteoporosis-is there an association? (in eng). Dig Dis Sci 64:2736–2739. https://doi.org/10.1007/s10620-019-05775-4CrossRef

Gennari L, Merlotti D, Figura N, Mingiano C, Franci MB, Lucani B, Picchioni T, Alessandri M, Campagna MS, Gonnelli S, Bianciardi S, Materozzi M, Caffarelli C, Gonnelli S, Nuti R (2021) Infection by CagA-positive helicobacter pylori strains and bone fragility: a prospective cohort study (in eng). J Bone Miner Res 36:80–89. https://doi.org/10.1002/jbmr.4162CrossRef

10.

Figura N, Gennari L, Merlotti D, Lenzi C, Campagna S, Franci B, Lucani B, Trabalzini L, Bianciardi L, Gonnelli C, Santucci A, Nut A (2005) Prevalence of Helicobacter pylori infection in male patients with osteoporosis and controls (in eng). Dig Dis Sci 50:847–852. https://doi.org/10.1007/s10620-005-2651-4CrossRef

11.

Kakehasi AM, Mendes CM, Coelho LG, Castro LP, Barbosa AJ (2007) The presence of Helicobacter pylori in postmenopausal women is not a factor to the decrease of bone mineral density (in eng). Arq Gastroenterol 44:266–270. https://doi.org/10.1590/s0004-28032007000300016CrossRef

12.

Akkaya N, Akkaya S, Polat Y, Turk M, Turk T, Ergur S, Sahin F (2011) Helicobacter pylori seropositivity in patients with postmenopausal osteoporosis. J Phys Ther Sci 23:61–64. https://doi.org/10.1589/jpts.23.61CrossRef

13.

Chinda D, Shimoyama T, Matsuzaka M, Danjo K, Nakaji S, Fukuda S (2013) Assessment of the association between helicobacter pylori infection and osteopenia in japanese healthy adults. Helicobacter 18:114

14.

Lin SC, Koo M, Tsai KW (2014) Association between helicobacter pylori infection and risk of osteoporosis in elderly taiwanese women with upper gastrointestinal diseases: a retrospective patient record review (in eng). Gastroenterol Res Pract 2014:814756. https://doi.org/10.1155/2014/814756CrossRef

15.

Chung YH, Gwak JS, Hong SW, Hyeon JH, Lee CM, Oh SW, Kwon H (2015) Helicobacter pylori: a possible risk factor for bone health (in eng). Korean J Fam Med 36:239–244. https://doi.org/10.4082/kjfm.2015.36.5.239CrossRef

16.

Asaoka D, Nagahara A, Shimada Y, Matsumoto K, Ueyama H, Matsumoto K, Nakagawa Y, Takeda T, Tanaka I, Osada T, Hojo M, Watanabe S (2015) Sa1806 risk factors for osteoporosis—are infection or eradication of helicobacter pylori associated? Gastroenterology 148:S337–S338CrossRef

17.

Mizuno S, Matsui D, Watanabe I, Ozaki E, Kuriyama N, Watanabe Y (2015) Serologically determined gastric mucosal condition is a predictive factor for osteoporosis in japanese men (in eng). Dig Dis Sci 60:2063–2069. https://doi.org/10.1007/s10620-015-3576-1CrossRef

18.

Fotouk-Kiai M, Hoseini SR, Meftah N, Ghadimi R, Bijani A, Noreddini H, Nematollahi H, Shokri-Shirvani J (2015) Relationship between Helicobacter pylori infection (HP) and bone mineral density (BMD) in elderly people (in eng). Caspian J Intern Med 6:62–66

19.

Kalantarhormozi MR, Assadi M, Vahdat K, Asadipooya K, Ostovar A, Raissi K, Darabi H, Farrokhi S, Dobaradaran S, Farrokhnia M, Nabipour I (2016) Chlamydia pneumoniae and Helicobacter pylori IgG seropositivities are not predictors of osteoporosis-associated bone loss: a prospective cohort study (in eng). J Bone Miner Metab 34:422–428. https://doi.org/10.1007/s00774-015-0688-9CrossRef

20.

Chinda D, Shimoyama T, Iino C, Matsuzaka M, Nakaji S, Fukuda S (2017) Decrease of estradiol and several lifestyle factors, but not helicobacter pylori infection, are significant risks for osteopenia in japanese females (in eng). Digestion 96:103–109. https://doi.org/10.1159/000479317CrossRef

21.

Abdolahi N, Aghaei M, Naghdi M (2017) AB0850 Helicobacter pylori infection and osteoporosis in post monopausal women. Ann Rheum Dis 76:1354. https://doi.org/10.1136/annrheumdis-2017-eular.6445CrossRef

22.

Lu LJ, Hao NB, Liu JJ, Li X, Wang RL (2018) Correlation between helicobacter pylori infection and metabolic abnormality in general population: a cross-sectional study (in eng). Gastroenterol Res Pract 2018:7410801. https://doi.org/10.1155/2018/7410801CrossRef

23.

Pan BL, Huang CF, Chuah SK, Chiang JC, Loke SS (2018) Relationship between Helicobacter pylori infection and bone mineral density: a retrospective cross-sectional study (in eng). BMC Gastroenterol 18:54. https://doi.org/10.1186/s12876-018-0780-4CrossRef

24.

Chinda D, Shimoyama T, Sawada K, Iino C, Sakuraba H, Nakaji S, Fukuda S (2019) Lifestyle factors rather than helicobacter pylori infection or estradiol level are associated with Osteopenia in Japanese men (in eng). Am J Mens Health 13:1557988319848219. https://doi.org/10.1177/1557988319848219CrossRef

25.

Wang JW, Dong FX, Su H, Zhu L, Shao S, Liu H (2020) Pylori is related to osteoporosis but only in premenopausal female: a cross-sectional study (in eng). BMC Musculoskelet Disord 21:559. https://doi.org/10.1186/s12891-020-03586-7CrossRef

26.

Kim TJ, Lee H, Min YW, Min BH, Lee JH, Rhee PL, Kim JJ (2021) Cohort study of Helicobacter pylori infection and the risk of incident osteoporosis in women (in eng). J Gastroenterol Hepatol 36:657–663. https://doi.org/10.1111/jgh.15181CrossRef

27.

Urgancı N, Kalyoncu D (2020) Assessment of bone metabolism and bone mineral density in children with helicobacter pylori infection. Med J Bakirkoy. https://doi.org/10.5222/bmj.2020.35229CrossRef

28.

Ye YF, Chen YH, Hong D, Jiesisibieke ZL, Tung TH, Zhang MX (2022) Association of Helicobacter pylori infection with osteoporosis risk in a physical examination population (in eng). Arch Osteoporos 17:35. https://doi.org/10.1007/s11657-022-01074-0CrossRef

29.

Huang J, Liu Z, Ma J, Liu J, Lv M, Wang F, Tang X (2022) The Association between helicobacter pylori seropositivity and bone mineral density in adults (in eng). Mediators Inflamm 2022:2364666. https://doi.org/10.1155/2022/2364666CrossRef

30.

Kakehasi AM, Rodrigues CB, Carvalho AV, Barbosa AJ (2009) Chronic gastritis and bone mineral density in women (in eng). Dig Dis Sci 54:819–824. https://doi.org/10.1007/s10620-008-0417-5CrossRef

31.

Upala S, Sanguankeo A, Wijarnpreecha K, Jaruvongvanich V (2016) Association between Helicobacter pylori infection and osteoporosis: a systematic review and meta-analysis (in eng). J Bone Miner Metab 34:482–483. https://doi.org/10.1007/s00774-015-0703-1CrossRef

32.

Wang T, Li X, Zhang Q, Ge B, Zhang J, Yu L, Cai T, Zhang Y, Xiong H (2019) Relationship between Helicobacter pylori infection and osteoporosis: a systematic review and meta-analysis (in eng). BMJ Open 9:e027356. https://doi.org/10.1136/bmjopen-2018-027356CrossRef

33.

Bravo D, Hoare A, Soto C, Valenzuela MA, Quest AF (2018) Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects (in eng). World J Gastroenterol 24:3071–3089. https://doi.org/10.3748/wjg.v24.i28.3071CrossRef

34.

Romero-Adrián TB, Leal-Montiel J, Monsalve-Castillo F, Mengual-Moreno E, McGregor EG, Perini L, Antúnez A (2010) Helicobacter pylori: bacterial factors and the role of cytokines in the immune response (in eng). Curr Microbiol 60:143–155. https://doi.org/10.1007/s00284-009-9518-4CrossRef

35.

Uotani T, Murakami K, Uchida T, Tanaka S, Nagashima H, Zeng XL, Akada J, Estes MK, Graham DY, Yamaoka Y (2019) Changes of tight junction and interleukin-8 expression using a human gastroid monolayer model of Helicobacter pylori infection (in eng). Helicobacter 24:e12583. https://doi.org/10.1111/hel.12583CrossRef

36.

Yamaoka Y (2010) Mechanisms of disease: Helicobacter pylori virulence factors (in eng). Nat Rev Gastroenterol Hepatol 7:629–641. https://doi.org/10.1038/nrgastro.2010.154CrossRef

37.

Collodel G, Moretti E, Campagna MS, Capitani S, Lenzi C, Figura N (2010) Infection by CagA-positive Helicobacter pylori strains may contribute to alter the sperm quality of men with fertility disorders and increase the systemic levels of TNF-alpha (in eng). Dig Dis Sci 55:94–100. https://doi.org/10.1007/s10620-008-0704-1CrossRef

38.

Redlich K, Smolen JS (2012) Inflammatory bone loss: pathogenesis and therapeutic intervention (in eng). Nat Rev Drug Discov 11:234–250. https://doi.org/10.1038/nrd3669CrossRef

39.

Polzer K, Joosten L, Gasser J, Distler JH, Ruiz G, Baum W, Redlich K, Bobacz K, Smolen JS, van den Berg W, Schett G, Zwerina J (2010) Interleukin-1 is essential for systemic inflammatory bone loss (in eng). Ann Rheum Dis 69:284–290. https://doi.org/10.1136/ard.2008.104786CrossRef

40.

Andersen BN, Johansen PB, Abrahamsen B (2016) Proton pump inhibitors and osteoporosis (in eng). Curr Opin Rheumatol 28:420–425. https://doi.org/10.1097/bor.0000000000000291CrossRef

41.

Adams AL, Black MH, Zhang JL, Shi JM, Jacobsen SJ (2014) Proton-pump inhibitor use and hip fractures in men: a population-based case-control study (in eng). Ann Epidemiol 24:286–290. https://doi.org/10.1016/j.annepidem.2014.01.004CrossRef

42.

Schinke T, Schilling AF, Baranowsky A, Seitz S, Marshall RP et al (2009) Impaired gastric acidification negatively affects calcium homeostasis and bone mass (in eng). Nat Med 15:674–681. https://doi.org/10.1038/nm.1963CrossRef

43.

Kim HW, Kim YH, Han K, Nam GE, Kim GS, Han BD, Lee A, Ahn JY, Ko BJ (2014) Atrophic gastritis: a related factor for osteoporosis in elderly women (in eng). PLoS ONE 9:e101852. https://doi.org/10.1371/journal.pone.0101852CrossRef

44.

Ueyama T, Shirasawa N, Numazawa M, Yamada K, Shelangouski M, Ito T, Tsuruo Y (2002) Gastric parietal cells: potent endocrine role in secreting estrogen as a possible regulator of gastro-hepatic axis (in eng). Endocrinology 143:3162–3170. https://doi.org/10.1210/endo.143.8.8974CrossRef

45.

Ueyama T, Shirasawa N, Ito T, Tsuruo Y (2004) Estrogen-producing steroidogenic pathways in parietal cells of the rat gastric mucosa (in eng). Life Sci 74:2327–2337. https://doi.org/10.1016/j.lfs.2003.10.005CrossRef

46.

Osawa H, Nakazato M, Date Y, Kita H, Ohnishi H, Ueno H, Shiiya T, Satoh K, Ishino Y, Sugano K (2005) Impaired production of gastric ghrelin in chronic gastritis associated with Helicobacter pylori (in eng). J Clin Endocrinol Metab 90:10–16. https://doi.org/10.1210/jc.2004-1330CrossRef

47.

Fukushima N, Hanada R, Teranishi H, Fukue Y, Tachibana T, Ishikawa H, Takeda S, Takeuchi Y, Fukumoto S, Kangawa K, Nagata K, Kojima M (2005) Ghrelin directly regulates bone formation (in eng). J Bone Miner Res 20:790–798. https://doi.org/10.1359/jbmr.041237CrossRef

48.

Censini S, Lange C, Xiang Z, Crabtree JE, Ghiara P, Borodovsky M, Rappuoli R, Covacci A (1996) cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors (in eng). Proc Natl Acad Sci U S A 93:14648–14653. https://doi.org/10.1073/pnas.93.25.14648CrossRef

Titel: Is Helicobacter pylori infection associated with osteoporosis? a systematic review and meta-analysis
verfasst von: Chuang Xiong
Runhan Zhao
Jingtao Xu
Hao Liang
Jun Zhang
Yanran Huang
Xiaoji Luo
Publikationsdatum: 08.11.2022
Verlag: Springer Nature Singapore
Erschienen in: Journal of Bone and Mineral Metabolism / Ausgabe 1/2023
Print ISSN: 0914-8779
Elektronische ISSN: 1435-5604
DOI: https://doi.org/10.1007/s00774-022-01379-7

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Alphablocker schützt vor Miktionsproblemen nach der Biopsie

16.05.2024 alpha-1-Rezeptorantagonisten Nachrichten

Nach einer Prostatabiopsie treten häufig Probleme beim Wasserlassen auf. Ob sich das durch den periinterventionellen Einsatz von Alphablockern verhindern lässt, haben australische Mediziner im Zuge einer Metaanalyse untersucht.

Eingreifen von Umstehenden rettet vor Erstickungstod!

15.05.2024 Fremdkörperaspiration Nachrichten

Wer sich an einem Essensrest verschluckt und um Luft ringt, benötigt vor allem rasche Hilfe. Dass Umstehende nur in jedem zweiten Erstickungsnotfall bereit waren, diese zu leisten, ist das ernüchternde Ergebnis einer Beobachtungsstudie aus Japan. Doch es gibt auch eine gute Nachricht.

Neue S3-Leitlinie zur unkomplizierten Zystitis: Auf Antibiotika verzichten?

15.05.2024 Harnwegsinfektionen Nachrichten

Welche Antibiotika darf man bei unkomplizierter Zystitis verwenden und wovon sollte man die Finger lassen? Welche pflanzlichen Präparate können helfen? Was taugt der zugelassene Impfstoff? Antworten vom Koordinator der frisch überarbeiteten S3-Leitlinie, Prof. Florian Wagenlehner.

Schadet Ärger den Gefäßen?

14.05.2024 Arteriosklerose Nachrichten

In einer Studie aus New York wirkte sich Ärger kurzfristig deutlich negativ auf die Endothelfunktion gesunder Probanden aus. Möglicherweise hat dies Einfluss auf die kardiovaskuläre Gesundheit.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Introduction

Materials and methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2023

Vitamin D deficiency in children with severe disabilities under limited ultraviolet exposure

Fibroblast growth factor 8 (FGF8) up-regulates gelatinase expression in chondrocytes through nuclear factor-κB p65

Loss of height predicts fall risk in elderly Japanese: a prospective cohort study

The effect of ferritin levels on distal femoral cartilage thickness in patients with beta thalassaemia major

The effect of the exercise environment and the level of involvement on bone mineral health