Erschienen in:
15.07.2016 | Short Communication
JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7
verfasst von:
David N. Soleimani-Meigooni, Katherine E. Schwetye, Maria Reyes Angeles, Caroline F. Ryschkewitsch, Eugene O. Major, Xin Dang, Igor J. Koralnik, Robert E. Schmidt, David B. Clifford, F. Matthew Kuhlmann, Robert C. Bucelli
Erschienen in:
Journal of NeuroVirology
|
Ausgabe 1/2017
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Abstract
JC virus (JCV) is a human polyomavirus that infects the central nervous system (CNS) of immunocompromised patients. JCV granule cell neuronopathy (JCV-GCN) is caused by infection of cerebellar granule cells, causing ataxia. A 77-year-old man with iatrogenic lymphopenia presented with severe ataxia and was diagnosed with JCV-GCN. His ataxia and cerebrospinal fluid (CSF) improved with intravenous immunoglobulin, high-dose intravenous methylprednisolone, mirtazapine, and mefloquine. Interleukin-7 (IL-7) therapy reconstituted his lymphocytes and reduced his CSF JCV load. One month after IL-7 therapy, he developed worsening ataxia and CSF inflammation, which raised suspicion for immune reconstitution inflammatory syndrome. Steroids were restarted and his ataxia stabilized.