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Pediatric Nephrology
Erschienen in: Pediatric Nephrology 9/2011

01.09.2011 | Review

Kidney and urinary tract development: an apoptotic balancing act

verfasst von: Katherine Stewart, Maxime Bouchard

Erschienen in: Pediatric Nephrology | Ausgabe 9/2011

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Abstract

Development of the mammalian urogenital system requires a balance between survival and programmed cell death. Pro-survival molecules are crucial in preserving metanephric mesenchyme viability, and thus allowing nephrogenesis to proceed. At the same time, localized areas of apoptosis mediated by effector caspases are required for the appropriate morphogenesis of the kidney and urinary tract. Activation of the intrinsic pathway of apoptosis seems to be fundamental to the progression of cell death necessary to aid ureteric bud branching, nephrogenesis, and ureter-bladder connection. Here, we review what is currently known about survival and apoptosis in building functional kidneys and urinary tracts.
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Metadaten
Titel
Kidney and urinary tract development: an apoptotic balancing act
verfasst von
Katherine Stewart
Maxime Bouchard
Publikationsdatum
01.09.2011
Verlag
Springer Berlin Heidelberg
Erschienen in
Pediatric Nephrology / Ausgabe 9/2011
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-011-1788-y

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