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2019 | OriginalPaper | Buchkapitel

38. Kutane lymphoproliferative und hämatopoietische Erkrankungen

verfasst von : Prof. Dr. Werner Kempf, Prof. Dr. Eva Geissinger

Erschienen in: Pathologie

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Kutane Manifestationen sind bei hämatologischen Erkrankungen häufig. Darüber hinaus sind inzwischen viele primär kutane Lymphoproliferationen und Lymphomentitäten des T-, NK- und der dendritischen Vorläuferzellpopulationen definiert. Das Spektrum hat sich seit der letzten Überarbeitung der WHO erheblich erweitert und spezifiziert. Im vorliegenden Kapitel sind alle nach der neuen WHO klassifizierten lymphatischen Neoplasien behandelt und nach diagnostischen klinischen und pathologischen Strategien und Differenzialdiagnosen dargestellt. Damit stellt es für alle klinisch tätigen Dermatologen und Pathologen eine aktuelle und relevante und nach funktionellen Kriterien geordnete Übersicht dar.
Literatur
1.
Zurück zum Zitat Baefverstedt B (1944) Ueber lymphadenosis benigna cutis. Eine klinische pathologisch-anatomische Studie. Acta Derm Venereol 24(Suppl XI):1–102 Baefverstedt B (1944) Ueber lymphadenosis benigna cutis. Eine klinische pathologisch-anatomische Studie. Acta Derm Venereol 24(Suppl XI):1–102
2.
Zurück zum Zitat Baldassano MF, Bailey EM, Ferry JA et al (1999) Cutaneous lymphoid hyperplasia and cutaneous marginal zone lymphoma: comparison of morphologic and immunophenotypic features. Am J Surg Pathol 23:88–96CrossRefPubMed Baldassano MF, Bailey EM, Ferry JA et al (1999) Cutaneous lymphoid hyperplasia and cutaneous marginal zone lymphoma: comparison of morphologic and immunophenotypic features. Am J Surg Pathol 23:88–96CrossRefPubMed
3.
Zurück zum Zitat Beaty MW, Toro J, Sorbara L et al (2001) Cutaneous lymphomatoid granulomatosis: correlation of clinical and biologic features. Am J Surg Pathol 25:1111–1120CrossRefPubMed Beaty MW, Toro J, Sorbara L et al (2001) Cutaneous lymphomatoid granulomatosis: correlation of clinical and biologic features. Am J Surg Pathol 25:1111–1120CrossRefPubMed
4.
Zurück zum Zitat Bekkenk MW, Geelen FA, Van Voorst Vader PC et al (2000) Primary and secondary cutaneous CD30(+) lymphoproliferative disorders: a report from the Dutch Cutaneous Lymphoma Group on the long-term follow-up data of 219 patients and guidelines for diagnosis and treatment. Blood 95:3653–3661PubMed Bekkenk MW, Geelen FA, Van Voorst Vader PC et al (2000) Primary and secondary cutaneous CD30(+) lymphoproliferative disorders: a report from the Dutch Cutaneous Lymphoma Group on the long-term follow-up data of 219 patients and guidelines for diagnosis and treatment. Blood 95:3653–3661PubMed
5.
Zurück zum Zitat Bekkenk MW, Vermeer MH, Jansen PM et al (2003) Peripheral T-cell lymphomas unspecified presenting in the skin: analysis of prognostic factors in a group of 82 patients. Blood 102:2213–2219CrossRefPubMed Bekkenk MW, Vermeer MH, Jansen PM et al (2003) Peripheral T-cell lymphomas unspecified presenting in the skin: analysis of prognostic factors in a group of 82 patients. Blood 102:2213–2219CrossRefPubMed
6.
Zurück zum Zitat Beljaards RC, Meijer CJ, Van Der Putte SC et al (1994) Primary cutaneous T-cell lymphoma: clinicopathological features and prognostic parameters of 35 cases other than mycosis fungoides and CD30-positive large cell lymphoma. J Pathol 172:53–60CrossRefPubMed Beljaards RC, Meijer CJ, Van Der Putte SC et al (1994) Primary cutaneous T-cell lymphoma: clinicopathological features and prognostic parameters of 35 cases other than mycosis fungoides and CD30-positive large cell lymphoma. J Pathol 172:53–60CrossRefPubMed
7.
Zurück zum Zitat Beltraminelli H, Leinweber B, Kerl H et al (2009) Primary cutaneous CD4+ small-/medium-sized pleomorphic T-cell lymphoma: a cutaneous nodular proliferation of pleomorphic T lymphocytes of undetermined significance? A study of 136 cases. Am J Dermatopathol 31:317–322CrossRefPubMed Beltraminelli H, Leinweber B, Kerl H et al (2009) Primary cutaneous CD4+ small-/medium-sized pleomorphic T-cell lymphoma: a cutaneous nodular proliferation of pleomorphic T lymphocytes of undetermined significance? A study of 136 cases. Am J Dermatopathol 31:317–322CrossRefPubMed
8.
Zurück zum Zitat Benner MF, Willemze R (2009) Applicability and prognostic value of the new TNM classification system in 135 patients with primary cutaneous anaplastic large cell lymphoma. Arch Dermatol 145:1399–1404CrossRefPubMed Benner MF, Willemze R (2009) Applicability and prognostic value of the new TNM classification system in 135 patients with primary cutaneous anaplastic large cell lymphoma. Arch Dermatol 145:1399–1404CrossRefPubMed
9.
Zurück zum Zitat Berti E, Recalcati S, Girgenti V et al (2010) Cutaneous extranodal NK/T-cell lymphoma: a clinicopathologic study of 5 patients with array-based comparative genomic hybridization. Blood 116:165–170CrossRefPubMed Berti E, Recalcati S, Girgenti V et al (2010) Cutaneous extranodal NK/T-cell lymphoma: a clinicopathologic study of 5 patients with array-based comparative genomic hybridization. Blood 116:165–170CrossRefPubMed
10.
Zurück zum Zitat Berti E, Tomasini D, Vermeer MH et al (1999) Primary cutaneous CD8-positive epidermotropic cytotoxic T cell lymphomas. A distinct clinicopathological entity with an aggressive clinical behavior. Am J Pathol 155:483–492PubMedPubMedCentralCrossRef Berti E, Tomasini D, Vermeer MH et al (1999) Primary cutaneous CD8-positive epidermotropic cytotoxic T cell lymphomas. A distinct clinicopathological entity with an aggressive clinical behavior. Am J Pathol 155:483–492PubMedPubMedCentralCrossRef
11.
Zurück zum Zitat Brenner I, Roth S, Puppe B et al (2013) Primary cutaneous marginal zone lymphomas with plasmacytic differentiation show frequent IgG4 expression. Mod Pathol 26:1568–1576PubMedCrossRef Brenner I, Roth S, Puppe B et al (2013) Primary cutaneous marginal zone lymphomas with plasmacytic differentiation show frequent IgG4 expression. Mod Pathol 26:1568–1576PubMedCrossRef
12.
Zurück zum Zitat Buechner SA, Li CY, Su WP (1985) Leukemia cutis. A histopathologic study of 42 cases. Am J Dermatopathol 7:109–119PubMedCrossRef Buechner SA, Li CY, Su WP (1985) Leukemia cutis. A histopathologic study of 42 cases. Am J Dermatopathol 7:109–119PubMedCrossRef
13.
Zurück zum Zitat Buechner SA, Winkelmann RK (1983) Sezary syndrome. A clinicopathologic study of 39 cases. Arch Dermatol 119:979–986PubMedCrossRef Buechner SA, Winkelmann RK (1983) Sezary syndrome. A clinicopathologic study of 39 cases. Arch Dermatol 119:979–986PubMedCrossRef
14.
Zurück zum Zitat Burg G, Kempf W, Kazakov DV et al (2003) Pyogenic lymphoma of the skin: a peculiar variant of primary cutaneous neutrophil-rich CD30+ anaplastic large-cell lymphoma. Clinicopathological study of four cases and review of the literature. Br J Dermatol 148:580–586PubMedCrossRef Burg G, Kempf W, Kazakov DV et al (2003) Pyogenic lymphoma of the skin: a peculiar variant of primary cutaneous neutrophil-rich CD30+ anaplastic large-cell lymphoma. Clinicopathological study of four cases and review of the literature. Br J Dermatol 148:580–586PubMedCrossRef
15.
Zurück zum Zitat Campbell JJ, Clark RA, Watanabe R et al (2010) Sezary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors. Blood 116:767–771PubMedPubMedCentralCrossRef Campbell JJ, Clark RA, Watanabe R et al (2010) Sezary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors. Blood 116:767–771PubMedPubMedCentralCrossRef
16.
Zurück zum Zitat Cerroni L, Kerl H (2001) Primary cutaneous follicle center cell lymphoma. Leuk Lymphoma 42:891–900PubMedCrossRef Cerroni L, Kerl H (2001) Primary cutaneous follicle center cell lymphoma. Leuk Lymphoma 42:891–900PubMedCrossRef
17.
Zurück zum Zitat Cerroni L, Massone C, Kutzner H et al (2008) Intravascular large T-cell or NK-cell lymphoma: a rare variant of intravascular large cell lymphoma with frequent cytotoxic phenotype and association with Epstein-Barr virus infection. Am J Surg Pathol 32:891–898PubMedCrossRef Cerroni L, Massone C, Kutzner H et al (2008) Intravascular large T-cell or NK-cell lymphoma: a rare variant of intravascular large cell lymphoma with frequent cytotoxic phenotype and association with Epstein-Barr virus infection. Am J Surg Pathol 32:891–898PubMedCrossRef
18.
Zurück zum Zitat Cerroni L, Signoretti S, Hofler G et al (1997) Primary cutaneous marginal zone B-cell lymphoma: a recently described entity of low-grade malignant cutaneous B-cell lymphoma [see comments. Am J Surg Pathol 21:1307–1315PubMedCrossRef Cerroni L, Signoretti S, Hofler G et al (1997) Primary cutaneous marginal zone B-cell lymphoma: a recently described entity of low-grade malignant cutaneous B-cell lymphoma [see comments. Am J Surg Pathol 21:1307–1315PubMedCrossRef
19.
Zurück zum Zitat Cerroni L, Zenahlik P, Hofler G et al (1996) Specific cutaneous infiltrates of B-cell chronic lymphocytic leukemia: a clinicopathologic and prognostic study of 42 patients. Am J Surg Pathol 20:1000–1010PubMedCrossRef Cerroni L, Zenahlik P, Hofler G et al (1996) Specific cutaneous infiltrates of B-cell chronic lymphocytic leukemia: a clinicopathologic and prognostic study of 42 patients. Am J Surg Pathol 20:1000–1010PubMedCrossRef
20.
Zurück zum Zitat Cerroni L, Zochling N, Putz B et al (1997) Infection by Borrelia burgdorferi and cutaneous B-cell lymphoma. J Cutan Pathol 24:457–461PubMedCrossRef Cerroni L, Zochling N, Putz B et al (1997) Infection by Borrelia burgdorferi and cutaneous B-cell lymphoma. J Cutan Pathol 24:457–461PubMedCrossRef
21.
Zurück zum Zitat Child FJ, Jones RR, Woolford AJ et al (2001) Absence of the t(14;18) chromosomal translocation in primary cutaneous B-cell lymphoma. Br J Dermatol 144:735–744CrossRefPubMed Child FJ, Jones RR, Woolford AJ et al (2001) Absence of the t(14;18) chromosomal translocation in primary cutaneous B-cell lymphoma. Br J Dermatol 144:735–744CrossRefPubMed
22.
Zurück zum Zitat Chimenti S, Fink-Puches R, Peris K et al (1999) Cutaneous involvement in lymphoblastic lymphoma. J Cutan Pathol 26:379–385CrossRefPubMed Chimenti S, Fink-Puches R, Peris K et al (1999) Cutaneous involvement in lymphoblastic lymphoma. J Cutan Pathol 26:379–385CrossRefPubMed
23.
Zurück zum Zitat Colli C, Leinweber B, Mullegger R et al (2004) Borrelia burgdorferi-associated lymphocytoma cutis: clinicopathologic, immunophenotypic, and molecular study of 106 cases. J Cutan Pathol 31:232–240CrossRefPubMed Colli C, Leinweber B, Mullegger R et al (2004) Borrelia burgdorferi-associated lymphocytoma cutis: clinicopathologic, immunophenotypic, and molecular study of 106 cases. J Cutan Pathol 31:232–240CrossRefPubMed
24.
Zurück zum Zitat Cota C, Vale E, Viana I et al (2010) Cutaneous manifestations of blastic plasmacytoid dendritic cell neoplasm-morphologic and phenotypic variability in a series of 33 patients. Am J Surg Pathol 34:75–87CrossRefPubMed Cota C, Vale E, Viana I et al (2010) Cutaneous manifestations of blastic plasmacytoid dendritic cell neoplasm-morphologic and phenotypic variability in a series of 33 patients. Am J Surg Pathol 34:75–87CrossRefPubMed
25.
Zurück zum Zitat Decoteau JF, Butmarc JR, Kinney MC et al (1996) The t(2;5) chromosomal translocation is not a common feature of primary cutaneous CD30+ lymphoproliferative disorders: comparison with anaplastic large-cell lymphoma of nodal origin. Blood 87:3437–3441PubMed Decoteau JF, Butmarc JR, Kinney MC et al (1996) The t(2;5) chromosomal translocation is not a common feature of primary cutaneous CD30+ lymphoproliferative disorders: comparison with anaplastic large-cell lymphoma of nodal origin. Blood 87:3437–3441PubMed
26.
Zurück zum Zitat Dummer R, Cozzio A, Urosevic M (2006) Pathogenesis and therapy of cutaneous lymphomas--progress or impasse? Exp Dermatol 15:392–400CrossRefPubMed Dummer R, Cozzio A, Urosevic M (2006) Pathogenesis and therapy of cutaneous lymphomas--progress or impasse? Exp Dermatol 15:392–400CrossRefPubMed
27.
Zurück zum Zitat El Shabrawi-Caelen L, Kerl H, Cerroni L (2004) Lymphomatoid papulosis: reappraisal of clinicopathologic presentation and classification into subtypes A, B, and C. Arch Dermatol 140:441–447PubMed El Shabrawi-Caelen L, Kerl H, Cerroni L (2004) Lymphomatoid papulosis: reappraisal of clinicopathologic presentation and classification into subtypes A, B, and C. Arch Dermatol 140:441–447PubMed
28.
Zurück zum Zitat Ferreri AJ, Campo E, Seymour JF et al (2004) Intravascular lymphoma: clinical presentation, natural history, management and prognostic factors in a series of 38 cases, with special emphasis on the ’cutaneous variant’. Br J Haematol 127:173–183CrossRefPubMed Ferreri AJ, Campo E, Seymour JF et al (2004) Intravascular lymphoma: clinical presentation, natural history, management and prognostic factors in a series of 38 cases, with special emphasis on the ’cutaneous variant’. Br J Haematol 127:173–183CrossRefPubMed
29.
Zurück zum Zitat Flaig MJ, Schuhmann K, Sander CA (2000) Impact of molecular analysis in the diagnosis of cutaneous lymphoid infiltrates. Semin Cutan Med Surg 19:87–90CrossRefPubMed Flaig MJ, Schuhmann K, Sander CA (2000) Impact of molecular analysis in the diagnosis of cutaneous lymphoid infiltrates. Semin Cutan Med Surg 19:87–90CrossRefPubMed
30.
Zurück zum Zitat Fried I, Artl M, Cota C et al (2014) Clinicopathologic and molecular features in cutaneous extranodal natural killer-/T-cell lymphoma, nasal type, with aggressive and indolent course. J Am Acad Dermatol 70:716–723CrossRefPubMed Fried I, Artl M, Cota C et al (2014) Clinicopathologic and molecular features in cutaneous extranodal natural killer-/T-cell lymphoma, nasal type, with aggressive and indolent course. J Am Acad Dermatol 70:716–723CrossRefPubMed
31.
Zurück zum Zitat Garcia-Herrera A, Colomo L, Camos M et al (2008) Primary cutaneous small/medium CD4+ T-cell lymphomas: a heterogeneous group of tumors with different clinicopathologic features and outcome. J Clin Oncol 26:3364–3371CrossRefPubMed Garcia-Herrera A, Colomo L, Camos M et al (2008) Primary cutaneous small/medium CD4+ T-cell lymphomas: a heterogeneous group of tumors with different clinicopathologic features and outcome. J Clin Oncol 26:3364–3371CrossRefPubMed
32.
33.
Zurück zum Zitat Geissinger E, Sadler P, Roth S et al (2010) Disturbed expression of the T-cell receptor/CD3 complex and associated signaling molecules in CD30+ T-cell lymphoproliferations. Haematologica 95:1697–1704PubMedPubMedCentralCrossRef Geissinger E, Sadler P, Roth S et al (2010) Disturbed expression of the T-cell receptor/CD3 complex and associated signaling molecules in CD30+ T-cell lymphoproliferations. Haematologica 95:1697–1704PubMedPubMedCentralCrossRef
34.
Zurück zum Zitat Gellrich S, Rutz S, Golembowski S et al (2001) Primary cutaneous follicle center cell lymphomas and large B cell lymphomas of the leg descend from germinal center cells. A single cell polymerase chain reaction analysis. J Invest Dermatol 117:1512–1520CrossRefPubMed Gellrich S, Rutz S, Golembowski S et al (2001) Primary cutaneous follicle center cell lymphomas and large B cell lymphomas of the leg descend from germinal center cells. A single cell polymerase chain reaction analysis. J Invest Dermatol 117:1512–1520CrossRefPubMed
35.
Zurück zum Zitat Golling P, Cozzio A, Dummer R et al (2008) Primary cutaneous B-cell lymphomas – clinicopathological, prognostic and therapeutic characterisation of 54 cases according to the WHO-EORTC classification and the ISCL/EORTC TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sezary syndrome. Leuk Lymphoma 49:1094–1103CrossRefPubMed Golling P, Cozzio A, Dummer R et al (2008) Primary cutaneous B-cell lymphomas – clinicopathological, prognostic and therapeutic characterisation of 54 cases according to the WHO-EORTC classification and the ISCL/EORTC TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sezary syndrome. Leuk Lymphoma 49:1094–1103CrossRefPubMed
36.
Zurück zum Zitat Goodlad JR, Krajewski AS, Batstone PJ et al (2002) Primary cutaneous follicular lymphoma: a clinicopathologic and molecular study of 16 cases in support of a distinct entity. Am J Surg Pathol 26:733–741CrossRefPubMed Goodlad JR, Krajewski AS, Batstone PJ et al (2002) Primary cutaneous follicular lymphoma: a clinicopathologic and molecular study of 16 cases in support of a distinct entity. Am J Surg Pathol 26:733–741CrossRefPubMed
37.
Zurück zum Zitat Guitart J, Weisenburger DD, Subtil A et al (2012) Cutaneous gammadelta T-cell lymphomas: a spectrum of presentations with overlap with other cytotoxic lymphomas. Am J Surg Pathol 36:1656–1665CrossRefPubMed Guitart J, Weisenburger DD, Subtil A et al (2012) Cutaneous gammadelta T-cell lymphomas: a spectrum of presentations with overlap with other cytotoxic lymphomas. Am J Surg Pathol 36:1656–1665CrossRefPubMed
38.
Zurück zum Zitat Haghighi B, Smoller BR, Leboit PE et al (2000) Pagetoid reticulosis (Woringer-Kolopp disease): an immunophenotypic, molecular, and clinicopathologic study. Mod Pathol 13:502–510CrossRefPubMed Haghighi B, Smoller BR, Leboit PE et al (2000) Pagetoid reticulosis (Woringer-Kolopp disease): an immunophenotypic, molecular, and clinicopathologic study. Mod Pathol 13:502–510CrossRefPubMed
39.
Zurück zum Zitat Hembury TA, Lee B, Gascoyne RD et al (2002) Primary cutaneous diffuse large B-cell lymphoma: a clinicopathologic study of 15 cases. Am J Clin Pathol 117:574–580CrossRefPubMed Hembury TA, Lee B, Gascoyne RD et al (2002) Primary cutaneous diffuse large B-cell lymphoma: a clinicopathologic study of 15 cases. Am J Clin Pathol 117:574–580CrossRefPubMed
40.
Zurück zum Zitat Hoefnagel JJ, Vermeer MH, Jansen PM et al (2003) Bcl-2, Bcl-6 and CD10 expression in cutaneous B-cell lymphoma: further support for a follicle centre cell origin and differential diagnostic significance. Br J Dermatol 149:1183–1191PubMedCrossRef Hoefnagel JJ, Vermeer MH, Jansen PM et al (2003) Bcl-2, Bcl-6 and CD10 expression in cutaneous B-cell lymphoma: further support for a follicle centre cell origin and differential diagnostic significance. Br J Dermatol 149:1183–1191PubMedCrossRef
41.
Zurück zum Zitat Hoefnagel JJ, Vermeer MH, Jansen PM et al (2005) Primary cutaneous marginal zone B-cell lymphoma: clinical and therapeutic features in 50 cases. Arch Dermatol 141:1139–1145PubMedCrossRef Hoefnagel JJ, Vermeer MH, Jansen PM et al (2005) Primary cutaneous marginal zone B-cell lymphoma: clinical and therapeutic features in 50 cases. Arch Dermatol 141:1139–1145PubMedCrossRef
42.
Zurück zum Zitat Hofbauer GF, Kessler B, Kempf W et al (2001) Multilesional primary cutaneous diffuse large B-cell lymphoma responsive to antibiotic treatment. Dermatology 203:168–170PubMedCrossRef Hofbauer GF, Kessler B, Kempf W et al (2001) Multilesional primary cutaneous diffuse large B-cell lymphoma responsive to antibiotic treatment. Dermatology 203:168–170PubMedCrossRef
43.
Zurück zum Zitat Hoque SR, Child FJ, Whittaker SJ et al (2003) Subcutaneous panniculitis-like T-cell lymphoma: a clinicopathological, immunophenotypic and molecular analysis of six patients. Br J Dermatol 148:516–525PubMedCrossRef Hoque SR, Child FJ, Whittaker SJ et al (2003) Subcutaneous panniculitis-like T-cell lymphoma: a clinicopathological, immunophenotypic and molecular analysis of six patients. Br J Dermatol 148:516–525PubMedCrossRef
44.
Zurück zum Zitat Iwatsuki K, Ohtsuka M, Akiba H et al (1999) Atypical hydroa vacciniforme in childhood: from a smoldering stage to Epstein-Barr virus-associated lymphoid malignancy. J Am Acad Dermatol 40:283–284CrossRefPubMed Iwatsuki K, Ohtsuka M, Akiba H et al (1999) Atypical hydroa vacciniforme in childhood: from a smoldering stage to Epstein-Barr virus-associated lymphoid malignancy. J Am Acad Dermatol 40:283–284CrossRefPubMed
45.
Zurück zum Zitat Jawed SI, Myskowski PL, Horwitz S et al (2014) Primary cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome): part I. Diagnosis: clinical and histopathologic features and new molecular and biologic markers. J Am Acad Dermatol 70:205e201–205e216 (quiz 221–202)CrossRef Jawed SI, Myskowski PL, Horwitz S et al (2014) Primary cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome): part I. Diagnosis: clinical and histopathologic features and new molecular and biologic markers. J Am Acad Dermatol 70:205e201–205e216 (quiz 221–202)CrossRef
46.
Zurück zum Zitat Joly P, Vasseur E, Esteve E et al (1995) Primary cutaneous medium and large cell lymphomas other than mycosis fungoides. An immunohistological and follow-up study on 54 cases. French Study Group for Cutaneous Lymphomas. Br J Dermatol 132:506–512CrossRefPubMed Joly P, Vasseur E, Esteve E et al (1995) Primary cutaneous medium and large cell lymphomas other than mycosis fungoides. An immunohistological and follow-up study on 54 cases. French Study Group for Cutaneous Lymphomas. Br J Dermatol 132:506–512CrossRefPubMed
47.
Zurück zum Zitat Kaddu S, Zenahlik P, Beham-Schmid C et al (1999) Specific cutaneous infiltrates in patients with myelogenous leukemia: a clinicopathologic study of 26 patients with assessment of diagnostic criteria. J Am Acad Dermatol 40:966–978CrossRefPubMed Kaddu S, Zenahlik P, Beham-Schmid C et al (1999) Specific cutaneous infiltrates in patients with myelogenous leukemia: a clinicopathologic study of 26 patients with assessment of diagnostic criteria. J Am Acad Dermatol 40:966–978CrossRefPubMed
48.
Zurück zum Zitat Kadin ME, Levi E, Kempf W (2001) Progression of lymphomatoid papulosis to systemic lymphoma is associated with escape from growth inhibition by TGF-beta and CD30 ligand. Ann N Y Acad Sci 941:59–68CrossRefPubMed Kadin ME, Levi E, Kempf W (2001) Progression of lymphomatoid papulosis to systemic lymphoma is associated with escape from growth inhibition by TGF-beta and CD30 ligand. Ann N Y Acad Sci 941:59–68CrossRefPubMed
49.
Zurück zum Zitat Karai LJ, Kadin ME, Hsi ED et al (2013) Chromosomal rearrangements of 6p25.3 define a new subtype of lymphomatoid papulosis. Am J Surg Pathol 37:1173–1181CrossRefPubMed Karai LJ, Kadin ME, Hsi ED et al (2013) Chromosomal rearrangements of 6p25.3 define a new subtype of lymphomatoid papulosis. Am J Surg Pathol 37:1173–1181CrossRefPubMed
50.
Zurück zum Zitat Kazakov DV, Burg G, Dummer R et al (2002) Cutaneous lymphomas and pseudolymphomas: newly described entities. Recent Results Cancer Res 160:283–293PubMedCrossRef Kazakov DV, Burg G, Dummer R et al (2002) Cutaneous lymphomas and pseudolymphomas: newly described entities. Recent Results Cancer Res 160:283–293PubMedCrossRef
51.
Zurück zum Zitat Kazakov DV, Burg G, Kempf W (2004) Clinicopathological spectrum of mycosis fungoides. J Eur Acad Dermatol Venereol 18:397–415PubMedCrossRef Kazakov DV, Burg G, Kempf W (2004) Clinicopathological spectrum of mycosis fungoides. J Eur Acad Dermatol Venereol 18:397–415PubMedCrossRef
52.
Zurück zum Zitat Kempf W (2006) CD30+ lymphoproliferative disorders: histopathology, differential diagnosis, new variants, and simulators. J Cutan Pathol 33(Suppl 1):58–70PubMedCrossRef Kempf W (2006) CD30+ lymphoproliferative disorders: histopathology, differential diagnosis, new variants, and simulators. J Cutan Pathol 33(Suppl 1):58–70PubMedCrossRef
53.
Zurück zum Zitat Kempf W (2014) Cutaneous CD30-positive lymphoproliferative disorders. Surg Pathol Clin 7:203–228PubMedCrossRef Kempf W (2014) Cutaneous CD30-positive lymphoproliferative disorders. Surg Pathol Clin 7:203–228PubMedCrossRef
54.
Zurück zum Zitat Kempf W, Denisjuk N, Kerl K et al (2012) Primary cutaneous B-cell lymphomas. J Dtsch Dermatol Ges 10:12–22 (quiz 23)PubMed Kempf W, Denisjuk N, Kerl K et al (2012) Primary cutaneous B-cell lymphomas. J Dtsch Dermatol Ges 10:12–22 (quiz 23)PubMed
55.
Zurück zum Zitat Kempf W, Kadin ME, Dvorak AM et al (2003) Endogenous retroviral elements, but not exogenous retroviruses, are detected in CD30-positive lymphoproliferative disorders of the skin. Carcinogenesis 24:301–306PubMedCrossRef Kempf W, Kadin ME, Dvorak AM et al (2003) Endogenous retroviral elements, but not exogenous retroviruses, are detected in CD30-positive lymphoproliferative disorders of the skin. Carcinogenesis 24:301–306PubMedCrossRef
56.
Zurück zum Zitat Kempf W, Kazakov DV, Cozzio A et al (2013) Primary cutaneous CD8(+) small- to medium-sized lymphoproliferative disorder in extrafacial sites: clinicopathologic features and concept on their classification. Am J Dermatopathol 35:159–166PubMedCrossRef Kempf W, Kazakov DV, Cozzio A et al (2013) Primary cutaneous CD8(+) small- to medium-sized lymphoproliferative disorder in extrafacial sites: clinicopathologic features and concept on their classification. Am J Dermatopathol 35:159–166PubMedCrossRef
57.
Zurück zum Zitat Kempf W, Kazakov DV, Kerl K (2014) Cutaneous lymphomas: an update. Part 1: T-cell and natural killer/t-cell lymphomas and related conditions. Am J Dermatopathol 36:105–123PubMedCrossRef Kempf W, Kazakov DV, Kerl K (2014) Cutaneous lymphomas: an update. Part 1: T-cell and natural killer/t-cell lymphomas and related conditions. Am J Dermatopathol 36:105–123PubMedCrossRef
58.
Zurück zum Zitat Kempf W, Kazakov DV, Mitteldorf C (2014) Cutaneous lymphomas: an update. Part 2: B-cell lymphomas and related conditions. Am J Dermatopathol 36:197–208 (quiz 209–110)PubMedCrossRef Kempf W, Kazakov DV, Mitteldorf C (2014) Cutaneous lymphomas: an update. Part 2: B-cell lymphomas and related conditions. Am J Dermatopathol 36:197–208 (quiz 209–110)PubMedCrossRef
59.
Zurück zum Zitat Kempf W, Kazakov DV, Scharer L et al (2013) Angioinvasive lymphomatoid papulosis: a new variant simulating aggressive lymphomas. Am J Surg Pathol 37:1–13PubMedCrossRef Kempf W, Kazakov DV, Scharer L et al (2013) Angioinvasive lymphomatoid papulosis: a new variant simulating aggressive lymphomas. Am J Surg Pathol 37:1–13PubMedCrossRef
60.
Zurück zum Zitat Kempf W, Levi E, Kamarashev J et al (2002) Fascin expression in CD30-positive cutaneous lymphoproliferative disorders. J Cutan Pathol 29:295–300PubMedCrossRef Kempf W, Levi E, Kamarashev J et al (2002) Fascin expression in CD30-positive cutaneous lymphoproliferative disorders. J Cutan Pathol 29:295–300PubMedCrossRef
61.
Zurück zum Zitat Kempf W, Ostheeren-Michaelis S, Paulli M et al (2008) Granulomatous mycosis fungoides and granulomatous slack skin: a multicenter study of the Cutaneous Lymphoma Histopathology Task Force Group of the European Organization For Research and Treatment of Cancer (EORTC). Arch Dermatol 144:1609–1617PubMedCrossRef Kempf W, Ostheeren-Michaelis S, Paulli M et al (2008) Granulomatous mycosis fungoides and granulomatous slack skin: a multicenter study of the Cutaneous Lymphoma Histopathology Task Force Group of the European Organization For Research and Treatment of Cancer (EORTC). Arch Dermatol 144:1609–1617PubMedCrossRef
62.
Zurück zum Zitat Kempf W, Pfaltz K, Vermeer MH et al (2011) EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. Blood 118:4024–4035PubMedPubMedCentralCrossRef Kempf W, Pfaltz K, Vermeer MH et al (2011) EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. Blood 118:4024–4035PubMedPubMedCentralCrossRef
63.
Zurück zum Zitat Kempf W, Rozati S, Kerl K et al (2012) Cutaneous peripheral T-cell lymphomas, unspecified/NOS and rare subtypes: a heterogeneous group of challenging cutaneous lymphomas. G Ital Dermatol Venereol 147:553–562PubMed Kempf W, Rozati S, Kerl K et al (2012) Cutaneous peripheral T-cell lymphomas, unspecified/NOS and rare subtypes: a heterogeneous group of challenging cutaneous lymphomas. G Ital Dermatol Venereol 147:553–562PubMed
64.
Zurück zum Zitat Kodama K, Massone C, Chott A et al (2005) Primary cutaneous large B-cell lymphomas: clinicopathologic features, classification, and prognostic factors in a large series of patients. Blood 106:2491–2497PubMedCrossRef Kodama K, Massone C, Chott A et al (2005) Primary cutaneous large B-cell lymphomas: clinicopathologic features, classification, and prognostic factors in a large series of patients. Blood 106:2491–2497PubMedCrossRef
65.
Zurück zum Zitat Kulow BF, Cualing H, Steele P et al (2002) Progression of cutaneous B-cell pseudolymphoma to cutaneous B-cell lymphoma. J Cutan Med Surg 6:519–528CrossRefPubMed Kulow BF, Cualing H, Steele P et al (2002) Progression of cutaneous B-cell pseudolymphoma to cutaneous B-cell lymphoma. J Cutan Med Surg 6:519–528CrossRefPubMed
66.
Zurück zum Zitat Kumar S, Krenacs L, Medeiros J et al (1998) Subcutaneous panniculitic T-cell lymphoma is a tumor of cytotoxic T lymphocytes. Hum Pathol 29:397–403PubMedCrossRef Kumar S, Krenacs L, Medeiros J et al (1998) Subcutaneous panniculitic T-cell lymphoma is a tumor of cytotoxic T lymphocytes. Hum Pathol 29:397–403PubMedCrossRef
67.
Zurück zum Zitat Kummer JA, Vermeer MH, Dukers D et al (1997) Most primary cutaneous CD30-positive lymphoproliferative disorders have a CD4-positive cytotoxic T-cell phenotype. J Invest Dermatol 109:636–640PubMedCrossRef Kummer JA, Vermeer MH, Dukers D et al (1997) Most primary cutaneous CD30-positive lymphoproliferative disorders have a CD4-positive cytotoxic T-cell phenotype. J Invest Dermatol 109:636–640PubMedCrossRef
69.
Zurück zum Zitat Lee WJ, Jung JM, Won CH et al (2014) Cutaneous extranodal natural killer/T-cell lymphoma: a comparative clinicohistopathologic and survival outcome analysis of 45 cases according to the primary tumor site. J Am Acad Dermatol 70:1002–1009PubMedCrossRef Lee WJ, Jung JM, Won CH et al (2014) Cutaneous extranodal natural killer/T-cell lymphoma: a comparative clinicohistopathologic and survival outcome analysis of 45 cases according to the primary tumor site. J Am Acad Dermatol 70:1002–1009PubMedCrossRef
70.
Zurück zum Zitat Lessin SR, Vowels BR, Rook AH (1994) Retroviruses and cutaneous T-cell lymphoma. Dermatol Clin 12:243–253CrossRefPubMed Lessin SR, Vowels BR, Rook AH (1994) Retroviruses and cutaneous T-cell lymphoma. Dermatol Clin 12:243–253CrossRefPubMed
71.
Zurück zum Zitat Lutzner MA, Jordan HW (1968) The ultrastructure of an abnormal cell in Sezary’s syndrome. Blood 31:719–726PubMed Lutzner MA, Jordan HW (1968) The ultrastructure of an abnormal cell in Sezary’s syndrome. Blood 31:719–726PubMed
72.
Zurück zum Zitat Macaulay WL (1968) Lymphomatoid papulosis. A continuing self-healing eruption, clinically benign--histologically malignant. Arch Dermatol 97:23–30PubMedCrossRef Macaulay WL (1968) Lymphomatoid papulosis. A continuing self-healing eruption, clinically benign--histologically malignant. Arch Dermatol 97:23–30PubMedCrossRef
73.
Zurück zum Zitat Marchetti MA, Pulitzer MP, Myskowski PL et al (2015) Cutaneous manifestations of human T-cell lymphotrophic virus type-1-associated adult T-cell leukemia/lymphoma: A single-center, retrospective study. J Am Acad Dermatol 72:293–301e292PubMedCrossRef Marchetti MA, Pulitzer MP, Myskowski PL et al (2015) Cutaneous manifestations of human T-cell lymphotrophic virus type-1-associated adult T-cell leukemia/lymphoma: A single-center, retrospective study. J Am Acad Dermatol 72:293–301e292PubMedCrossRef
74.
Zurück zum Zitat Martel P, Laroche L, Courville P et al (2000) Cutaneous involvement in patients with angioimmunoblastic lymphadenopathy with dysproteinemia: a clinical, immunohistological, and molecular analysis. Arch Dermatol 136:881–886CrossRefPubMed Martel P, Laroche L, Courville P et al (2000) Cutaneous involvement in patients with angioimmunoblastic lymphadenopathy with dysproteinemia: a clinical, immunohistological, and molecular analysis. Arch Dermatol 136:881–886CrossRefPubMed
75.
Zurück zum Zitat Martinez-Escaname M, Zuriel D, Tee SI et al (2013) Cutaneous infiltrates of acute myelogenous leukemia simulating inflammatory dermatoses. Am J Dermatopathol 35:419–424CrossRefPubMed Martinez-Escaname M, Zuriel D, Tee SI et al (2013) Cutaneous infiltrates of acute myelogenous leukemia simulating inflammatory dermatoses. Am J Dermatopathol 35:419–424CrossRefPubMed
76.
Zurück zum Zitat Massone C, Cerroni L (2014) Phenotypic variability in primary cutaneous anaplastic large T-cell lymphoma: a study on 35 patients. Am J Dermatopathol 36:153–157CrossRefPubMed Massone C, Cerroni L (2014) Phenotypic variability in primary cutaneous anaplastic large T-cell lymphoma: a study on 35 patients. Am J Dermatopathol 36:153–157CrossRefPubMed
77.
Zurück zum Zitat Massone C, Crisman G, Kerl H et al (2008) The prognosis of early mycosis fungoides is not influenced by phenotype and T-cell clonality. Br J Dermatol 159:881–886CrossRefPubMed Massone C, Crisman G, Kerl H et al (2008) The prognosis of early mycosis fungoides is not influenced by phenotype and T-cell clonality. Br J Dermatol 159:881–886CrossRefPubMed
78.
Zurück zum Zitat Massone C, El-Shabrawi-Caelen L, Kerl H et al (2008) The morphologic spectrum of primary cutaneous anaplastic large T-cell lymphoma: a histopathologic study on 66 biopsy specimens from 47 patients with report of rare variants. J Cutan Pathol 35:46–53CrossRefPubMed Massone C, El-Shabrawi-Caelen L, Kerl H et al (2008) The morphologic spectrum of primary cutaneous anaplastic large T-cell lymphoma: a histopathologic study on 66 biopsy specimens from 47 patients with report of rare variants. J Cutan Pathol 35:46–53CrossRefPubMed
79.
Zurück zum Zitat Massone C, Fink-Puches R, Laimer M et al (2011) Miliary and agminated-type primary cutaneous follicle center lymphoma: report of 18 cases. J Am Acad Dermatol 65:749–755CrossRefPubMed Massone C, Fink-Puches R, Laimer M et al (2011) Miliary and agminated-type primary cutaneous follicle center lymphoma: report of 18 cases. J Am Acad Dermatol 65:749–755CrossRefPubMed
80.
Zurück zum Zitat Massone C, Kodama K, Kerl H et al (2005) Histopathologic features of early (patch) lesions of mycosis fungoides: a morphologic study on 745 biopsy specimens from 427 patients. Am J Surg Pathol 29:550–560PubMedCrossRef Massone C, Kodama K, Kerl H et al (2005) Histopathologic features of early (patch) lesions of mycosis fungoides: a morphologic study on 745 biopsy specimens from 427 patients. Am J Surg Pathol 29:550–560PubMedCrossRef
81.
Zurück zum Zitat Michaelis S, Kazakov DV, Burg G et al (2006) Extracutaneous transformation into a high-grade lymphoma: a potential pitfall in the management of patients with Sezary syndrome. Int J Dermatol 45:277–279PubMedCrossRef Michaelis S, Kazakov DV, Burg G et al (2006) Extracutaneous transformation into a high-grade lymphoma: a potential pitfall in the management of patients with Sezary syndrome. Int J Dermatol 45:277–279PubMedCrossRef
82.
Zurück zum Zitat Michaelis S, Kazakov DV, Schmid M et al (2003) Hepatitis C and G viruses in B-cell lymphomas of the skin. J Cutan Pathol 30:369–372PubMedCrossRef Michaelis S, Kazakov DV, Schmid M et al (2003) Hepatitis C and G viruses in B-cell lymphomas of the skin. J Cutan Pathol 30:369–372PubMedCrossRef
83.
Zurück zum Zitat Moreau Cabarrot A, Bonafe JL, Gorguet B et al (1994) Papulose lymphomatoide et lymphome anaplasique a grandes cellules. Ann Dermatol Venereol 121:727–730PubMed Moreau Cabarrot A, Bonafe JL, Gorguet B et al (1994) Papulose lymphomatoide et lymphome anaplasique a grandes cellules. Ann Dermatol Venereol 121:727–730PubMed
84.
Zurück zum Zitat Mraz Gernhard S, Natkunam Y, Hoppe RT et al (2001) Natural killer/natural killer-like T-cell lymphoma, CD56+, presenting in the skin: an increasingly recognized entity with an aggressive course. J Clin Oncol 19:2179–2188PubMedCrossRef Mraz Gernhard S, Natkunam Y, Hoppe RT et al (2001) Natural killer/natural killer-like T-cell lymphoma, CD56+, presenting in the skin: an increasingly recognized entity with an aggressive course. J Clin Oncol 19:2179–2188PubMedCrossRef
85.
Zurück zum Zitat Nikolaou VA, Papadavid E, Katsambas A et al (2009) Clinical characteristics and course of CD8+ cytotoxic variant of mycosis fungoides: a case series of seven patients. Br J Dermatol 161:826–830PubMedCrossRef Nikolaou VA, Papadavid E, Katsambas A et al (2009) Clinical characteristics and course of CD8+ cytotoxic variant of mycosis fungoides: a case series of seven patients. Br J Dermatol 161:826–830PubMedCrossRef
86.
Zurück zum Zitat Nofal A, Abdel-Mawla MY, Assaf M et al (2012) Primary cutaneous aggressive epidermotropic CD8(+) T-cell lymphoma: Proposed diagnostic criteria and therapeutic evaluation. J Am Acad Dermatol 67:748–759PubMedCrossRef Nofal A, Abdel-Mawla MY, Assaf M et al (2012) Primary cutaneous aggressive epidermotropic CD8(+) T-cell lymphoma: Proposed diagnostic criteria and therapeutic evaluation. J Am Acad Dermatol 67:748–759PubMedCrossRef
87.
Zurück zum Zitat Olsen E, Vonderheid E, Pimpinelli N et al (2007) Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC). Blood 110:1713–1722CrossRefPubMed Olsen E, Vonderheid E, Pimpinelli N et al (2007) Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC). Blood 110:1713–1722CrossRefPubMed
88.
Zurück zum Zitat Palmedo G, Hantschke M, Rutten A et al (2007) Primary cutaneous marginal zone B-cell lymphoma may exhibit both the t(14;18)(q32;q21) IGH/BCL2 and the t(14;18)(q32;q21) IGH/MALT1 translocation: an indicator for clonal transformation towards higher-grade B-cell lymphoma? Am J Dermatopathol 29:231–236CrossRefPubMed Palmedo G, Hantschke M, Rutten A et al (2007) Primary cutaneous marginal zone B-cell lymphoma may exhibit both the t(14;18)(q32;q21) IGH/BCL2 and the t(14;18)(q32;q21) IGH/MALT1 translocation: an indicator for clonal transformation towards higher-grade B-cell lymphoma? Am J Dermatopathol 29:231–236CrossRefPubMed
89.
Zurück zum Zitat Paulli M, Berti E, Rosso R et al (1995) CD30/Ki-1-positive lymphoproliferative disorders of the skin – clinicopathologic correlation and statistical analysis of 86 cases: a multicentric study from the European Organization for Research and Treatment of Cancer Cutaneous Lymphoma Project Group. J Clin Oncol 13:1343–1354CrossRefPubMed Paulli M, Berti E, Rosso R et al (1995) CD30/Ki-1-positive lymphoproliferative disorders of the skin – clinicopathologic correlation and statistical analysis of 86 cases: a multicentric study from the European Organization for Research and Treatment of Cancer Cutaneous Lymphoma Project Group. J Clin Oncol 13:1343–1354CrossRefPubMed
90.
Zurück zum Zitat Perniciaro C, Winkelmann RK, Daoud MS et al (1995) Malignant angioendotheliomatosis is an angiotropic intravascular lymphoma. Immunohistochemical, ultrastructural, and molecular genetics studies. Am J Dermatopathol 17:242–248PubMedCrossRef Perniciaro C, Winkelmann RK, Daoud MS et al (1995) Malignant angioendotheliomatosis is an angiotropic intravascular lymphoma. Immunohistochemical, ultrastructural, and molecular genetics studies. Am J Dermatopathol 17:242–248PubMedCrossRef
91.
Zurück zum Zitat Petrella T, Bagot M, Willemze R et al (2005) Blastic NK-cell lymphomas (agranular CD4+CD56+ hematodermic neoplasms): a review. Am J Clin Pathol 123:662–675PubMedCrossRef Petrella T, Bagot M, Willemze R et al (2005) Blastic NK-cell lymphomas (agranular CD4+CD56+ hematodermic neoplasms): a review. Am J Clin Pathol 123:662–675PubMedCrossRef
92.
Zurück zum Zitat Petrella T, Maubec E, Cornillet-Lefebvre P et al (2007) Indolent CD8-positive lymphoid proliferation of the ear: a distinct primary cutaneous T-cell lymphoma? Am J Surg Pathol 31:1887–1892PubMedCrossRef Petrella T, Maubec E, Cornillet-Lefebvre P et al (2007) Indolent CD8-positive lymphoid proliferation of the ear: a distinct primary cutaneous T-cell lymphoma? Am J Surg Pathol 31:1887–1892PubMedCrossRef
93.
Zurück zum Zitat Pfaltz K, Kerl K, Palmedo G et al (2011) Clonality in sarcoidosis, granuloma annulare, and granulomatous mycosis fungoides. Am J Dermatopathol 33:659–662PubMedCrossRef Pfaltz K, Kerl K, Palmedo G et al (2011) Clonality in sarcoidosis, granuloma annulare, and granulomatous mycosis fungoides. Am J Dermatopathol 33:659–662PubMedCrossRef
94.
Zurück zum Zitat Pimpinelli N, Santucci M, Bosi A et al (1989) Primary cutaneous follicular centre-cell lymphoma--a lymphoproliferative disease with favourable prognosis. Clin Exp Dermatol 14:12–19PubMedCrossRef Pimpinelli N, Santucci M, Bosi A et al (1989) Primary cutaneous follicular centre-cell lymphoma--a lymphoproliferative disease with favourable prognosis. Clin Exp Dermatol 14:12–19PubMedCrossRef
95.
Zurück zum Zitat Pincus LB, Leboit PE, Mccalmont TH et al (2009) Subcutaneous panniculitis-like T-cell lymphoma with overlapping clinicopathologic features of lupus erythematosus: coexistence of 2 entities? Am J Dermatopathol 31:520–526PubMedCrossRef Pincus LB, Leboit PE, Mccalmont TH et al (2009) Subcutaneous panniculitis-like T-cell lymphoma with overlapping clinicopathologic features of lupus erythematosus: coexistence of 2 entities? Am J Dermatopathol 31:520–526PubMedCrossRef
96.
Zurück zum Zitat Ploysangam T, Breneman DL, Mutasim DF (1998) Cutaneous pseudolymphomas. J Am Acad Dermatol 38:877–895CrossRefPubMed Ploysangam T, Breneman DL, Mutasim DF (1998) Cutaneous pseudolymphomas. J Am Acad Dermatol 38:877–895CrossRefPubMed
97.
Zurück zum Zitat Poenitz N, Dippel E, Klemke CD et al (2003) Jessner’s lymphocytic infiltration of the skin: a CD8+ polyclonal reactive skin condition. Dermatology 207:276–284PubMedCrossRef Poenitz N, Dippel E, Klemke CD et al (2003) Jessner’s lymphocytic infiltration of the skin: a CD8+ polyclonal reactive skin condition. Dermatology 207:276–284PubMedCrossRef
98.
Zurück zum Zitat Poszepczynska-Guigne E, Schiavon V, D’incan M et al (2004) CD158k/KIR3DL2 is a new phenotypic marker of Sezary cells: relevance for the diagnosis and follow-up of Sezary syndrome. J Invest Dermatol 122:820–823PubMedCrossRef Poszepczynska-Guigne E, Schiavon V, D’incan M et al (2004) CD158k/KIR3DL2 is a new phenotypic marker of Sezary cells: relevance for the diagnosis and follow-up of Sezary syndrome. J Invest Dermatol 122:820–823PubMedCrossRef
99.
Zurück zum Zitat Pulitzer M, Myskowski PL, Horwitz SM et al (2014) Mycosis fungoides with large cell transformation: clinicopathological features and prognostic factors. Pathology 46:610–616PubMedCrossRef Pulitzer M, Myskowski PL, Horwitz SM et al (2014) Mycosis fungoides with large cell transformation: clinicopathological features and prognostic factors. Pathology 46:610–616PubMedCrossRef
100.
Zurück zum Zitat Ram-Wolff C, Martin-Garcia N, Bensussan A et al (2010) Histopathologic diagnosis of lymphomatous versus inflammatory erythroderma: a morphologic and phenotypic study on 47 skin biopsies. Am J Dermatopathol 32:755–763PubMedPubMedCentralCrossRef Ram-Wolff C, Martin-Garcia N, Bensussan A et al (2010) Histopathologic diagnosis of lymphomatous versus inflammatory erythroderma: a morphologic and phenotypic study on 47 skin biopsies. Am J Dermatopathol 32:755–763PubMedPubMedCentralCrossRef
101.
Zurück zum Zitat Robson A, Assaf C, Bagot M et al (2014) Aggressive epidermotropic cutaneous CD8+ lymphoma: a cutaneous lymphoma with distinct clinical and pathological features report of an EORTC cutaneous Lymphoma task force workshop. Histopathology 67:425–441CrossRef Robson A, Assaf C, Bagot M et al (2014) Aggressive epidermotropic cutaneous CD8+ lymphoma: a cutaneous lymphoma with distinct clinical and pathological features report of an EORTC cutaneous Lymphoma task force workshop. Histopathology 67:425–441CrossRef
102.
Zurück zum Zitat Rodriguez Pinilla SM, Roncador G, Rodriguez-Peralto JL et al (2009) Primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma expresses follicular T-cell markers. Am J Surg Pathol 33:81–90PubMedCrossRef Rodriguez Pinilla SM, Roncador G, Rodriguez-Peralto JL et al (2009) Primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma expresses follicular T-cell markers. Am J Surg Pathol 33:81–90PubMedCrossRef
103.
Zurück zum Zitat Rodriguez-Pinilla SM, Barrionuevo C, Garcia J et al (2010) EBV-associated cutaneous NK/T-cell lymphoma: review of a series of 14 cases from peru in children and young adults. Am J Surg Pathol 34:1773–1782PubMedCrossRef Rodriguez-Pinilla SM, Barrionuevo C, Garcia J et al (2010) EBV-associated cutaneous NK/T-cell lymphoma: review of a series of 14 cases from peru in children and young adults. Am J Surg Pathol 34:1773–1782PubMedCrossRef
104.
Zurück zum Zitat Roglin J, Boer A (2007) Skin manifestations of intravascular lymphoma mimic inflammatory diseases of the skin. Br J Dermatol 157:16–25CrossRefPubMed Roglin J, Boer A (2007) Skin manifestations of intravascular lymphoma mimic inflammatory diseases of the skin. Br J Dermatol 157:16–25CrossRefPubMed
105.
Zurück zum Zitat Rongioletti F, De Lucchi S, Meyes D et al (2010) Follicular mucinosis: a clinicopathologic, histochemical, immunohistochemical and molecular study comparing the primary benign form and the mycosis fungoides-associated follicular mucinosis. J Cutan Pathol 37:15–19CrossRefPubMed Rongioletti F, De Lucchi S, Meyes D et al (2010) Follicular mucinosis: a clinicopathologic, histochemical, immunohistochemical and molecular study comparing the primary benign form and the mycosis fungoides-associated follicular mucinosis. J Cutan Pathol 37:15–19CrossRefPubMed
106.
Zurück zum Zitat Russell-Jones R, Whittaker S (2000) Sezary syndrome: diagnostic criteria and therapeutic options. Semin Cutan Med Surg 19:100–108PubMed Russell-Jones R, Whittaker S (2000) Sezary syndrome: diagnostic criteria and therapeutic options. Semin Cutan Med Surg 19:100–108PubMed
107.
Zurück zum Zitat Saggini A, Gulia A, Argenyi Z et al (2010) A variant of lymphomatoid papulosis simulating primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma. Description of 9 cases. Am J Surg Pathol 34:1168–1175PubMedCrossRef Saggini A, Gulia A, Argenyi Z et al (2010) A variant of lymphomatoid papulosis simulating primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma. Description of 9 cases. Am J Surg Pathol 34:1168–1175PubMedCrossRef
108.
Zurück zum Zitat Sandberg Y, Van Gastel-Mol EJ, Verhaaf B et al (2005) BIOMED-2 multiplex immunoglobulin/T-cell receptor polymerase chain reaction protocols can reliably replace Southern blot analysis in routine clonality diagnostics. J Mol Diagn 7:495–503PubMedPubMedCentralCrossRef Sandberg Y, Van Gastel-Mol EJ, Verhaaf B et al (2005) BIOMED-2 multiplex immunoglobulin/T-cell receptor polymerase chain reaction protocols can reliably replace Southern blot analysis in routine clonality diagnostics. J Mol Diagn 7:495–503PubMedPubMedCentralCrossRef
109.
Zurück zum Zitat Sander CA, Flaig MJ (1999) Morphologic spectrum of cutaneous B-cell lymphomas. Dermatol Clin 17:593–599PubMedCrossRef Sander CA, Flaig MJ (1999) Morphologic spectrum of cutaneous B-cell lymphomas. Dermatol Clin 17:593–599PubMedCrossRef
110.
Zurück zum Zitat Sander CA, Medeiros LJ, Abruzzo LV et al (1991) Lymphoblastic lymphoma presenting in cutaneous sites. A clinicopathologic analysis of six cases. J Am Acad Dermatol 25:1023–1031CrossRefPubMed Sander CA, Medeiros LJ, Abruzzo LV et al (1991) Lymphoblastic lymphoma presenting in cutaneous sites. A clinicopathologic analysis of six cases. J Am Acad Dermatol 25:1023–1031CrossRefPubMed
111.
Zurück zum Zitat Santucci M, Pimpinelli N, Massi D et al (2003) Cytotoxic/natural killer cell cutaneous lymphomas. Report of EORTC Cutaneous Lymphoma Task Force Workshop. Cancer 97:610–627PubMedCrossRef Santucci M, Pimpinelli N, Massi D et al (2003) Cytotoxic/natural killer cell cutaneous lymphomas. Report of EORTC Cutaneous Lymphoma Task Force Workshop. Cancer 97:610–627PubMedCrossRef
112.
Zurück zum Zitat Sen F, Medeiros LJ, Lu D et al (2002) Mantle cell lymphoma involving skin: cutaneous lesions may be the first manifestation of disease and tumors often have blastoid cytologic features. Am J Surg Pathol 26:1312–1318CrossRefPubMed Sen F, Medeiros LJ, Lu D et al (2002) Mantle cell lymphoma involving skin: cutaneous lesions may be the first manifestation of disease and tumors often have blastoid cytologic features. Am J Surg Pathol 26:1312–1318CrossRefPubMed
113.
Zurück zum Zitat Senff NJ, Hoefnagel JJ, Jansen PM et al (2007) Reclassification of 300 primary cutaneous B-Cell lymphomas according to the new WHO-EORTC classification for cutaneous lymphomas: comparison with previous classifications and identification of prognostic markers. J Clin Oncol 25:1581–1587CrossRefPubMed Senff NJ, Hoefnagel JJ, Jansen PM et al (2007) Reclassification of 300 primary cutaneous B-Cell lymphomas according to the new WHO-EORTC classification for cutaneous lymphomas: comparison with previous classifications and identification of prognostic markers. J Clin Oncol 25:1581–1587CrossRefPubMed
114.
Zurück zum Zitat Senff NJ, Zoutman WH, Vermeer MH et al (2008) Fine-mapping chromosomal loss at 9p21: correlation with prognosis in primary cutaneous diffuse large b-cell lymphoma, leg type. J Invest Dermatol 129:1149–1155CrossRefPubMed Senff NJ, Zoutman WH, Vermeer MH et al (2008) Fine-mapping chromosomal loss at 9p21: correlation with prognosis in primary cutaneous diffuse large b-cell lymphoma, leg type. J Invest Dermatol 129:1149–1155CrossRefPubMed
115.
Zurück zum Zitat Sentis HJ, Willemze R, Scheffer E (1986) Histopathologic studies in Sezary syndrome and erythrodermic mycosis fungoides: a comparison with benign forms of erythroderma. J Am Acad Dermatol 15:1217–1226CrossRefPubMed Sentis HJ, Willemze R, Scheffer E (1986) Histopathologic studies in Sezary syndrome and erythrodermic mycosis fungoides: a comparison with benign forms of erythroderma. J Am Acad Dermatol 15:1217–1226CrossRefPubMed
116.
Zurück zum Zitat Servitje O, Estrach T, Pujol RM et al (2002) Primary cutaneous marginal zone B-cell lymphoma: a clinical, histopathological, immunophenotypic and molecular genetic study of 22 cases. Br J Dermatol 147:1147–1158CrossRefPubMed Servitje O, Estrach T, Pujol RM et al (2002) Primary cutaneous marginal zone B-cell lymphoma: a clinical, histopathological, immunophenotypic and molecular genetic study of 22 cases. Br J Dermatol 147:1147–1158CrossRefPubMed
117.
Zurück zum Zitat Servitje O, Muniesa C, Benavente Y et al (2013) Primary cutaneous marginal zone B-cell lymphoma: response to treatment and disease-free survival in a series of 137 patients. J Am Acad Dermatol 69:357–365CrossRefPubMed Servitje O, Muniesa C, Benavente Y et al (2013) Primary cutaneous marginal zone B-cell lymphoma: response to treatment and disease-free survival in a series of 137 patients. J Am Acad Dermatol 69:357–365CrossRefPubMed
118.
Zurück zum Zitat Siegel R, Gartenhaus R, Kuzel T (2001) HTLV-I associated leukemia/lymphoma: epidemiology, biology, and treatment. Cancer Treat Res 104:75–88CrossRefPubMed Siegel R, Gartenhaus R, Kuzel T (2001) HTLV-I associated leukemia/lymphoma: epidemiology, biology, and treatment. Cancer Treat Res 104:75–88CrossRefPubMed
119.
Zurück zum Zitat Simon M, Flaig MJ, Kind P et al (2000) Large plaque parapsoriasis: clinical and genotypic correlations. J Cutan Pathol 27:57–60CrossRefPubMed Simon M, Flaig MJ, Kind P et al (2000) Large plaque parapsoriasis: clinical and genotypic correlations. J Cutan Pathol 27:57–60CrossRefPubMed
120.
Zurück zum Zitat Storz MN, Van De Rijn Kim M, Kim YH et al (2003) Gene expression profiles of cutaneous B cell lymphoma. J Invest Dermatol 120:865–870PubMedCrossRef Storz MN, Van De Rijn Kim M, Kim YH et al (2003) Gene expression profiles of cutaneous B cell lymphoma. J Invest Dermatol 120:865–870PubMedCrossRef
121.
Zurück zum Zitat Suchak R, O’connor S, Mcnamara C et al (2010) Indolent CD8-positive lymphoid proliferation on the face: part of the spectrum of primary cutaneous small-/medium-sized pleomorphic T-cell lymphoma or a distinct entity? J Cutan Pathol 37:977–981PubMedCrossRef Suchak R, O’connor S, Mcnamara C et al (2010) Indolent CD8-positive lymphoid proliferation on the face: part of the spectrum of primary cutaneous small-/medium-sized pleomorphic T-cell lymphoma or a distinct entity? J Cutan Pathol 37:977–981PubMedCrossRef
122.
Zurück zum Zitat Swerdlow SH, Campo E, Pileri SA et al (2016) The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood 127:2375–2390PubMedPubMedCentralCrossRef Swerdlow SH, Campo E, Pileri SA et al (2016) The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood 127:2375–2390PubMedPubMedCentralCrossRef
123.
Zurück zum Zitat Tokura Y, Sawada Y, Shimauchi T (2014) Skin manifestations of adult T-cell leukemia/lymphoma: clinical, cytological and immunological features. J Dermatol 41:19–25PubMedCrossRef Tokura Y, Sawada Y, Shimauchi T (2014) Skin manifestations of adult T-cell leukemia/lymphoma: clinical, cytological and immunological features. J Dermatol 41:19–25PubMedCrossRef
124.
Zurück zum Zitat Trautinger F, Knobler R, Willemze R et al (2006) EORTC consensus recommendations for the treatment of mycosis fungoides/Sezary syndrome. Eur J Cancer 42:1014–1030CrossRefPubMed Trautinger F, Knobler R, Willemze R et al (2006) EORTC consensus recommendations for the treatment of mycosis fungoides/Sezary syndrome. Eur J Cancer 42:1014–1030CrossRefPubMed
125.
Zurück zum Zitat Tripodo C, Iannitto E, Florena AM et al (2009) Gamma-delta T-cell lymphomas. Nat Rev Clin Oncol 6:707–717PubMedCrossRef Tripodo C, Iannitto E, Florena AM et al (2009) Gamma-delta T-cell lymphomas. Nat Rev Clin Oncol 6:707–717PubMedCrossRef
126.
Zurück zum Zitat Trotter MJ, Whittaker SJ, Orchard GE et al (1997) Cutaneous histopathology of Sezary syndrome: a study of 41 cases with a proven circulating T-cell clone. J Cutan Pathol 24:286–291CrossRefPubMed Trotter MJ, Whittaker SJ, Orchard GE et al (1997) Cutaneous histopathology of Sezary syndrome: a study of 41 cases with a proven circulating T-cell clone. J Cutan Pathol 24:286–291CrossRefPubMed
127.
Zurück zum Zitat Van Doorn R, Scheffer E, Willemze R (2002) Follicular mycosis fungoides, a distinct disease entity with or without associated follicular mucinosis: a clinicopathologic and follow-up study of 51 patients. Arch Dermatol 138:191–198PubMed Van Doorn R, Scheffer E, Willemze R (2002) Follicular mycosis fungoides, a distinct disease entity with or without associated follicular mucinosis: a clinicopathologic and follow-up study of 51 patients. Arch Dermatol 138:191–198PubMed
128.
Zurück zum Zitat Van Doorn R, Van Haselen CW, Van Voorst Vader PC et al (2000) Mycosis fungoides: disease evolution and prognosis of 309 Dutch patients. Arch Dermatol 136:504–510PubMed Van Doorn R, Van Haselen CW, Van Voorst Vader PC et al (2000) Mycosis fungoides: disease evolution and prognosis of 309 Dutch patients. Arch Dermatol 136:504–510PubMed
129.
Zurück zum Zitat Van Haselen CW, Toonstra J, Van Der Putte SJ et al (1998) Granulomatous slack skin. Report of three patients with an updated review of the literature. Dermatology 196:382–391PubMedCrossRef Van Haselen CW, Toonstra J, Van Der Putte SJ et al (1998) Granulomatous slack skin. Report of three patients with an updated review of the literature. Dermatology 196:382–391PubMedCrossRef
130.
Zurück zum Zitat Van Vloten WA, Willemze R (2003) The many faces of lymphocytoma cutis. J Eur Acad Dermatol Venereol 17:3–6CrossRefPubMed Van Vloten WA, Willemze R (2003) The many faces of lymphocytoma cutis. J Eur Acad Dermatol Venereol 17:3–6CrossRefPubMed
131.
Zurück zum Zitat Vonderheid EC, Bernengo MG, Burg G et al (2002) Update on erythrodermic cutaneous T-cell lymphoma: report of the International Society for Cutaneous Lymphomas. J Am Acad Dermatol 46:95–106PubMedCrossRef Vonderheid EC, Bernengo MG, Burg G et al (2002) Update on erythrodermic cutaneous T-cell lymphoma: report of the International Society for Cutaneous Lymphomas. J Am Acad Dermatol 46:95–106PubMedCrossRef
132.
Zurück zum Zitat Wada DA, Law ME, Hsi ED et al (2011) Specificity of IRF4 translocations for primary cutaneous anaplastic large cell lymphoma: a multicenter study of 204 skin biopsies. Mod Pathol 24:596–605PubMedCrossRef Wada DA, Law ME, Hsi ED et al (2011) Specificity of IRF4 translocations for primary cutaneous anaplastic large cell lymphoma: a multicenter study of 204 skin biopsies. Mod Pathol 24:596–605PubMedCrossRef
133.
Zurück zum Zitat Walsh NM, Prokopetz R, Tron VA et al (1994) Histopathology in erythroderma: review of a series of cases by multiple observers. J Cutan Pathol 21:419–423PubMedCrossRef Walsh NM, Prokopetz R, Tron VA et al (1994) Histopathology in erythroderma: review of a series of cases by multiple observers. J Cutan Pathol 21:419–423PubMedCrossRef
134.
Zurück zum Zitat Werner B, Massone C, Kerl H et al (2008) Large CD30-positive cells in benign, atypical lymphoid infiltrates of the skin. J Cutan Pathol 35:1100–1107PubMedCrossRef Werner B, Massone C, Kerl H et al (2008) Large CD30-positive cells in benign, atypical lymphoid infiltrates of the skin. J Cutan Pathol 35:1100–1107PubMedCrossRef
135.
Zurück zum Zitat Willemze R, Jaffe ES, Burg G et al (2005) WHO-EORTC classification for cutaneous lymphomas. Blood 105:3768–3785CrossRefPubMed Willemze R, Jaffe ES, Burg G et al (2005) WHO-EORTC classification for cutaneous lymphomas. Blood 105:3768–3785CrossRefPubMed
136.
Zurück zum Zitat Willemze R, Jansen PM, Cerroni L et al (2008) Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases. Blood 111:838–845PubMedCrossRef Willemze R, Jansen PM, Cerroni L et al (2008) Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases. Blood 111:838–845PubMedCrossRef
137.
Zurück zum Zitat Wobser M, Roth S, Reinartz T et al (2015) CD68 expression is a discriminative feature of indolent cutaneous CD8-positive lymphoid proliferation and distinguishes this lymphoma subtype from other CD8-positive cutaneous lymphomas. Br J Dermatol 172:1573–1580PubMedCrossRef Wobser M, Roth S, Reinartz T et al (2015) CD68 expression is a discriminative feature of indolent cutaneous CD8-positive lymphoid proliferation and distinguishes this lymphoma subtype from other CD8-positive cutaneous lymphomas. Br J Dermatol 172:1573–1580PubMedCrossRef
138.
Zurück zum Zitat Wolf IH, Cerroni L, Fink-Puches R et al (2005) Das morphologische Spektrum der kutanen Pseudolymphome. J Dtsch Dermatol Ges 3:710–720 (quiz 721)CrossRefPubMed Wolf IH, Cerroni L, Fink-Puches R et al (2005) Das morphologische Spektrum der kutanen Pseudolymphome. J Dtsch Dermatol Ges 3:710–720 (quiz 721)CrossRefPubMed
139.
Zurück zum Zitat Wood GS, Tung RM, Haeffner AC et al (1994) Detection of clonal T-cell receptor gamma gene rearrangements in early mycosis fungoides/Sezary syndrome by polymerase chain reaction and denaturing gradient gel electrophoresis (PCR/DGGE). J Invest Dermatol 103:34–41PubMedCrossRef Wood GS, Tung RM, Haeffner AC et al (1994) Detection of clonal T-cell receptor gamma gene rearrangements in early mycosis fungoides/Sezary syndrome by polymerase chain reaction and denaturing gradient gel electrophoresis (PCR/DGGE). J Invest Dermatol 103:34–41PubMedCrossRef
140.
Zurück zum Zitat Wobser M, Maurus K, Roth S, Appenzeller S, Weyandt G, Goebeler M, Rosenwald A, Geissinger E (2017) Myeloid differentiation primary response 88 mutations in a distinct type of cutaneous marginal-zone lymphoma with a nonclass-switched immunoglobulin M immunophenotype. Br J Dermatol 177:564–566PubMedCrossRef Wobser M, Maurus K, Roth S, Appenzeller S, Weyandt G, Goebeler M, Rosenwald A, Geissinger E (2017) Myeloid differentiation primary response 88 mutations in a distinct type of cutaneous marginal-zone lymphoma with a nonclass-switched immunoglobulin M immunophenotype. Br J Dermatol 177:564–566PubMedCrossRef
141.
Metadaten
Titel
Kutane lymphoproliferative und hämatopoietische Erkrankungen
verfasst von
Prof. Dr. Werner Kempf
Prof. Dr. Eva Geissinger
Copyright-Jahr
2019
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-540-85184-4_38

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