Erschienen in:
01.12.2010 | Case report
Laparoscopic sleeve gastrectomy leads to rapid improvement of glucose tolerance and insulin secretion with enhanced glucagon-like peptide (GLP-1) secretion
verfasst von:
Satoshi Ugi, Hiroshi Yamamoto, Chisato Kusunoki, Azusa Kamo, Kazuhiro Ikeda, Tetsuya Hashimoto, Yoshihiko Nishio, Kazunori Kasama, Toru Tani, Atsunori Kashiwagi, Hiroshi Maegawa
Erschienen in:
Diabetology International
|
Ausgabe 2/2010
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Abstract
Objective
To examine the effect of laparoscopic sleeve gastrectomy (LSG) on glucose metabolism.
Methods
LSG was performed in two patients with diabetes and one with impaired glucose tolerance. An oral glucose tolerance test (OGTT) was performed preoperatively and 3 months postoperatively. Plasma glucose, insulin, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) levels were measured during the OGTT. Fasting ghrelin levels were also measured.
Results
Two diabetic patients discontinued oral hypoglycemic agents or insulin immediately post-surgery, and the HbA1c level was improved. The area under the curve for insulin and GLP-1 was increased after surgery. In contrast, GIP secretion did not change significantly. Fasting ghrelin levels were decreased in all patients.
Conclusions
LSG can lead to a rapid improvement of glucose tolerance with enhanced insulin secretion. Increased GLP-1 secretion and decreased ghrelin levels may play a role in improvement of glucose tolerance and insulin secretion after LSG.